Fakülteler / Faculties
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Item A 10-Year Experience of Tuberculosis in Solid-Organ Transplant Recipients(2015) Ulubay, Gaye; Kupeli, Elif; Birben, Ozlem Duvenci; Seyfettin, Emine Pinar; Dogrul, Mustafa Ilgaz; Ugurlu, Aylin Ozsancak; Eyuboglu, Fusun Oner; Haberal, Mehmet; 0000-0002-5525-8207; 0000-0002-3462-7632; 0000-0003-2478-9985; 0000-0003-3598-3986; 0000-0002-5826-1997; 25894157; AAR-4338-2020; AAJ-8097-2021; AAB-5064-2021; AAA-2925-2020; AAB-5345-2021Objectives: Tuberculosis remains an important problem in solid-organ transplant patients due to their immunocompromised state. The objective of the present study was to report the incidence, demographic characteristics, and various presentations of tuberculosis in solid-organ transplant recipients. Materials and Methods: We evaluated a total of 999 patients (male/female = 665/334, 661 renal and 338 liver transplants) who underwent solid-organ transplant between 2003 and 2013. The medical records of all patients were retrospectively reviewed. Patients' demographics, transplant type, primary site of tuberculosis specimen culture and pathology results, chest radiograph, and thoracic computed tomography findings, total blood count and chemistry were all recorded. Results: Among the 999 subjects, 19 patients (1.9%) (male/female: 15/4, mean +/- SD age, 42 +/- 18.5 y) were diagnosed with tuberculosis. The majority of patients (85%) were diagnosed with tuberculosis within 6 months after transplant, and 15% were diagnosed within 3 months. Most diagnoses of tuberculosis were based on histopathologic examination of biopsy material. Of these patients, 9 were diagnosed with pulmonary tuberculosis, 8 had extrapulmonary tuberculosis, and 2 had both. Nontuberculosis mycobacteria infections were detected in 3 patients. Conclusions: Even with a negative exposure history, tuberculosis can manifest as different clinic presentations in solid-organ transplant patients on immunosuppressive drugs, particularly in the first 6 months after transplant. Therefore, clinicians should always consider tuberculosis as the potential cause of an infectious disease with unknown cause to successfully diagnose and manage solid-organ transplant recipients.Item A 10-year retrospective analysis of intimate partner violence patients in the emergency department(2022) Kavak, Nezih; Kavak, Rasime Pelin; Ozdemir, Meltem; Sever, Mustafa; Ertan, Nurcan; 35652880BACKGROUND: Intimate partner violence (IPV) is an important human rights problem faced by one in three women worldwide. The aim of this study is to evaluate the demographic, trauma, and radiological characteristics of patients admitted to a tertiary emergency department due to IPV. METHODS: Sociodemographic characteristics (age, gender, education level, and marital status), trauma characteristics (severity, type, and location), radiological imaging findings (radiography, computed tomography, and magnetic resonance imaging) of patients diagnosed with IPV were evaluated. RESULTS: In the study, 1225 patients were evaluated, and 98.7% of them were women (mean age 35 [IQR: 17] years). Of the patients, 63.1% were high school and university graduates. The rate of married women was 74.6%. No relationship was found between gender, age, educational status, and marital status (p>0.05). Most of the traumas were minor (85.4%) and blunt (81.9%) trauma, and the most common types of trauma were kicking (49.9%) and punching (47.3%). It was found that the most frequently affected areas of the patients were the head and neck (76.7%), and the frequency of pelvic trauma was high in male patients (p<0.05). The most common bone fracture was nasal (40.5%) followed by ulna fractures (14.5%). The left-sided diaphyseal fractures were the most common in patients exposed to IPV. In our study, the frequency of mortality was 12.9%, and it was found to be significantly higher in males (p<0.05). CONCLUSION: Female patients are more frequently exposed to IPV. Specific injury characteristics can be detected in patients diagnosed with IPV and old fractures detected in these patients should alert the clinician about IPV.Item The 1934 Anti-Jewish Thrace Riots: the Jewish Exodus of Thrace Through the Lens of Nationalism and Collective Violence(2017) Eligur, Banu; AFR-3489-2022This article analyses the causes and the dynamic process of production of the 1934 anti-Jewish Thrace riots. The article, based on the US State Department Records, British Documents on Foreign Affairs and the Turkish Republic's Prime Ministry Republican Archives as well as Turkish, US and British newspapers, argues that the 1934 anti-Jewish Thrace riots were not spontaneous occurrences caused by over-excited masses, but instead planned actions by some local state elite and Republican People's Party (RPP) local officials as well as anti-Semitic Turkish ultra-nationalists. The article argues that it was not popular anti-Semitism, but the Turkish state establishment's security concerns vis-a-vis the perceived Italian and Bulgarian threat that resulted in the riots. The local state elite and RPP local officials, who were uneasy about the economically well-off Jews, acted as ethno-nationalist entrepreneurs by allowing the ultra-nationalists to operate in the riot-prone Thrace, while the rioters mainly participated in the collective violence to receive economic gains as a result of the expulsion of the Jews.Item The 2-Stage Liver Transplant: 3 Clinical Scenarios(2015) Gedik, Ender; Bicakcioglu, Murat; Otan, Emrah; Toprak, Huseyin Ilksen; Isik, Burak; Aydin, Cemalettin; Kayaalp, Cuneyt; Yilmaz, Sezai; 0000-0001-9293-8116; 0000-0002-2395-3985; 0000-0002-7175-207X; 0000-0003-4657-2998; 25894175; ABB-5579-2020; AAH-1764-2021; AAN-4023-2020; A-6657-2018; ABI-2971-2020The main goal of 2-stage liver transplant is to provide time to obtain a new liver source. We describe our experience of 3 patients with 3 different clinical conditions. A 57-year-old man was retransplanted successfully with this technique due to hepatic artery thrombosis. However, a 38-year-old woman with fulminant toxic hepatitis and a 5-year-old-boy with abdominal trauma had poor outcome. This technique could serve as a rescue therapy for liver transplant patients who have toxic liver syndrome or abdominal trauma. These patients required intensive support during long anhepatic states. The transplant team should decide early whether to use this technique before irreversible conditions develop.Item 2019 Expert opinion on biological treatment use in inflammatory bowel disease management(2019) Toruner, Murat; Akpinar, Hale; Akyuz, Filiz; Dagli, Ulku; Hamzaoglu, Hulya Over; Tezel, Ahmet; Unsal, Belkis; Yildirim, Suleyman; Celik, Aykut Ferhat; 32207688Item 2019 Turkish Hypertension Consensus Report(2019) Aydogdu, Sinan; Guler, Kerim; Bayram, Fahri; Altun, Bulent; Derici, Ulver; Abaci, Adnan; Tukek, Tufan; Sabuncu, Tevfik; Arici, Mustafa; Erdem, Yunus; Ozin, Bulent; Sahin, Ibrahim; Erturk, Sehsuvar; Bittigen, Atilla; Tokgozoglu, Lale; 31483311The Turkish Hypertension Consensus Report was prepared for the first time in 2015 to adapt the European and American international guidelines to our clinical practice and to create a practical report that could be a basic reference for all physicians dealing with hypertensive patients. This report, which was prepared by a committee with representation from 5 leading hypertension associations, has been accepted and is widely used. New clinical studies in hypertension literature and updated international guidelines since 2015 have demanded an update of the Turkish Hypertension Consensus Report as well. In this updated 2019 report, blood pressure levels were classified as Normal, Elevated, Stage 1, and Stage 2 hypertension. A new section was added for secondary hypertension. It was specified that drug treatment may be initiated with any 1 or a combination of 4 groups of drugs (diuretics, calcium channel blockers, angiotensin-converting enzyme [ACE] inhibitors, and angiotensin receptor blockers [ARBs]), except a combination of an ACE inhibitor and an ARB. It was emphasized that beta-blockers may be a first choice for hypertension treatment in diseases such as atrial fibrillation, heart failure, and coronary artery disease. The initial recommendation for hypertension treatment is a combination therapy in patients with a blood pressure level >= 150/90 mmHg. Target blood pressure values were redefined according to age and the presence of comorbidities. The hypertension treatment algorithm was renewed; it is proposed that drug therapy can also be initiated with a risk-based approach for the group with an elevated blood pressure (systolic blood pressure: 120-139 mmHg, diastolic blood pressure: 80-89 mmHg). The threshold clinic systolic blood pressure level was reduced from 160 mmHg to >= 150 mmHg for the initiation of drug therapy in individuals 80 years of age or more. The section on the treatment of special groups has now been expanded to include pregnancy and lactation. As in the previous report, in this update, practical recommendations for the most common cases seen in the clinic were the goal, rather than a comprehensive report that addresses all aspects of hypertension. This report has evidence-based recommendations for most patients; however, it should be kept in mind that there may be differences from 1 patient to another and that physicians should take an individualized approach according to a good clinical evaluation.Item The 2100 Mhz Radiofrequency Radiation of A 3G-Mobile Phone and The DNA Oxidative Damage in Brain(2016) Sahin, Duygu; Ozgur, Elcin; Guler, Goknur; Tomruk, Arin; Unlu, Ilhan; Sepici-Dincel, Aylin; Seyhan, Nesrin; 26775761We aimed to evaluate the effect of 2100 MHz radiofrequency radiation emitted by a generator, simulating a 3G-mobile phone on the brain of rats during 10 and 40 days of exposure. The female rats were randomly divided into four groups. Group I; exposed to 3G modulated 2100 MHz RFR signal for 6 h/day, 5 consecutive days/wk for 2 weeks, group II; control 10 days, were kept in an inactive exposure set-up for 6 h/day, 5 consecutive days/wk for 2 weeks, group III; exposed to 3G modulated 2100 MHz RFR signal for 6 h/day, 5 consecutive days/wk for 8 weeks and group IV; control 40 days, were kept in an inactive exposure set-up for 6 h/day, 5 consecutive days/wk for 8 weeks. After the genomic DNA content of brain was extracted, oxidative DNA damage (8-hydroxy-2'deoxyguanosine, pg/mL) and malondialdehyde (MDA, nmoL/g tissue) levels were determined. Our main finding was the increased oxidative DNA damage to brain after 10 days of exposure with the decreased oxidative DNA damage following 40 days of exposure compared to their control groups. Besides decreased lipid peroxidation end product, MDA, was observed after 40 days of exposure. The measured decreased quantities of damage during the 40 days of exposure could be the means of adapted and increased DNA repair mechanisms. (C) 2016 Elsevier B.V. All rights reserved.Item 22q13.3 Deletion Syndrome: An Underdiagnosed Cause of Mental Retardation(2015) Erol, Ilknur; Onay, Ozge Surmeli; Yilmaz, Zerrin; Ozer, Ozge; Alehan, Fusun; Sahin, Feride IffetPhelan-McDermid syndrome, also known as 22q13.3 deletion syndrome, is characterized by global developmental delay, absent or delayed speech, generalized hypotonia, and minor physical anomalies. The deletion typically involves the terminal band 22q13.3 and has been associated with both familial and de-novo translocations. We report the case of an 11-year-old Turkish girl with 22q13.3 deletion syndrome presenting with repeated seizures during the course of a rubella infection. We also review the clinical features of 22q13.3 deletion syndrome and emphasize the importance of considering a rare microdeletion syndrome for idiopathic mental retardation when results of a routine karyotype analysis are normal. To the best of our knowledge, this is the first reported case of a Turkish patient with isolated 22q13.3 deletion syndrome.Item 3D Printing in Endodontics: Report of Three Clinical Cases with Innovative Approaches(2021) Koc, Cemre; Capci, Abdullah; 345538963D printing is a process whereby a given material is deposited in successive layers to create a 3D object. In dentistry, this technology involves three steps: digital data acquisition using a scanner and/or CBCT, data processing and design within a software application, and manufacturing through 3D printing. The aim of the present article is to discuss the clinical application of 3D printing in endodontics through the presentation of three specific and original endodontic clinical cases. Innovative approaches were utilized in these cases for the treatment of a calcified root canal, periapical surgery, and autotransplantation. The results of all three cases were promising regarding proper case selection and in the design process. 3D-printing technology may be helpful to reduce surgical time, operator bias, and the risk of procedural errors.Item 3q29 Microdeletion Syndrome Associated with Developmental Delay and Pulmonary Stenosis: A Case Report(2022) Kaba, Duygu; celik, Zerrin Yilmaz; 36305444Background. 3q29 microdeletion syndrome (OMIM 609425), first described in 2005, is a rare copy number variation (CNV), accompanied by various neurodevelopmental and psychiatric problems. Phenotypic features of the syndrome have not been fully characterized due to the new definition and rarity. Facial dysmorphology, musculoskeletal anomalies, cardiovascular abnormalities, gastrointestinal abnormalities, and dental abnormalities can be seen.Case. A 28-month-old male patient was brought to the child and adolescent psychiatry clinic with a complaint of speech delay. He had mild dysmorphic symptoms. He was also sensitive to voice and often covered his ears. Balloon valvuloplasty was performed on the postnatal 28th day due to severe pulmonary stenosis. While karyotype was found to be normal, in array-Comparative genomic hybridization (aCGH), copy loss was detected in the long arm of chromosome 3 (arr[hg19] 3q29[196,209,689-197,601,344]x1), which contains approximately 1.4 Mb harboring 30 genes. Genetic counseling was given to the family of the patient who was diagnosed with 3q29 microdeletion syndrome.Conclusions. In conclusion, we present 3q29 microdeletion syndrome with global developmental delay (GDD), dysmorphic face, hyperacusis, scoliosis, and severe pulmonary stenosis. Performing genetic analysis in patients with developmental delay and congenital heart disease (CHD) for which the cause cannot be explained will prevent these rare diseases from being missed, and the characteristics of the diseases will be better characterized with the reported cases.Item A Configurational Approach for Analyzing Cultural Values and Performance in Global Virtual Teams(INTERNATIONAL BUSINESS REVIEW, 2024) Sahin, Faruk; Taras, Vas; Cetin, Fatih; Tavoletti, Ernesto; Askun, Duysal; Florea, LiviuAlthough there have been decades of research on the effect of cultural values on team effectiveness outcomes, knowledge of the interdependencies of team cultural values for explaining team performance remains nascent. Using a configurational qualitative approach, this study explores how cultural values combine and collectively contribute to the effectiveness of Global Virtual Teams (GVTs). We perform a fuzzy-set qualitative comparative analysis on a data set of 1847 individuals nested within 396 GVTs who participated in an international business consulting project. The results demonstrate that cultural values work together to achieve high levels of team performance rather than function independently. The results also show that different cultural value configurations could be equally effective at producing the same outcome, and that the presence of gender egalitarianism and the absence of power distance are the most important for producing the outcome. We discuss implications for practice and future research.Item A Critical Assessment Of The Design Displacements Of Friction Pendulum Systems(SOIL DYNAMICS AND EARTHQUAKE ENGINEERING, 2024-02) Alici, F. Soner; Sucuog, Haluk; Ozcamur, UgurcanThe equivalent linear static procedure suggested in seismic codes for determining the maximum displacements of seismic isolation systems is evaluated comprehensively for friction pendulum isolators with respect to the benchmark nonlinear response history analysis procedure for a set of radii of curvature and coefficients of friction. A large set of selected and scaled near field ground motions recorded on stiff and soft soils are employed in comparative evaluations. It has been observed that equivalent linear static procedure significantly overestimates the maximum isolator displacements for all practical combinations of radius of curvature and friction coefficient. Overestimation is larger for ground motions on soft soils. Alternatively, a practical description of inelastic displacement spectra is introduced where the hazard is defined in terms of the 1-second spectral acceleration accounting for the seismicity and soil class of the site, and friction pendulum isolation systems are characterized by their radius of curvature and nominal friction coefficient. Employing the proposed design spectra in design and production may lead to significant reductions of the isolator sizes. Moreover, realistic estimation of maximum isolator displacements also leads to realistic estimation of isolator stiffness, as well as the internal design forces of both the isolation system and the superstructure through response spectrum analysis under design spectrum.Item A Dss Development Study For Document Distribution Networks For Preparing Autonomous Vehicle-Integrated Distribution Systems(DECISION, 2024-12) Derya, Tusan; Ic, Yusuf Tansel; Erbay, Mehmet Dogan; Konuk, Kubra; Fidan, NihalWe propose a decision support system (DSS) to complete the tours of the routes of the traveler in charge of document distribution in the least amount of time for the document distribution task of a university to prepare autonomous vehicle-integrated distribution systems. A mathematical model-based decision support system is developed to determine distribution routes that optimize the total distance to target locations and obtain optimal system conditions for use in the migration of autonomous distribution systems. The purpose is to find the shortest-cost tours to cover all or subsets of edges in a network. Documents are shared and distributed by travelers to other related locations. Soon after, travelers will be replaced by autonomous vehicles. There are many application areas, such as newspapers and mail delivery systems. Therefore, the proposed model can be easily extended to other application areas, such as newspaper, cargo, and mail delivery systems, to construct autonomous vehicle-based systems.Item A Gastronomical product in Bursa Cuisine; Orhangazi Gedelek Pickles(INTERNATIONAL JOURNAL OF GASTRONOMY AND FOOD SCIENCE, 2024-03) Gulec, Hakan; Yilmaz, IlkayGastronomic identity of a region, consists of products grown, produced and presented in ways specific to that region, as well as geography, history, ethnic diversity, dietary habits and table manners, dominant flavors, and recipes. The concept of cuisine identity tries to make the cultures self-identified with cuisine, determine use of local material and the effect of various cultures upon foods and beverages. Local products are one of the components of gastronomical identity. Protection of these products and conveying them to the future generations is of importance in terms of sustaining the gastronomical definition. In this context, the aim of the research study is to determine the characteristics of Gedelek pickles, which is specific to Bursa's local cuisine, in the culinary culture and to examine its production phases. The research was carried out with 12 local producers making home-made production in the village of Gedelek of Bursa Orhangazi town by means of face-to-face with semi structured interviews. The study includes the opinions of local producers about the production, gastronomic value, new product and production techniques and sustainability of these local products bearing geographical indications. The most distinctive feature of Gedelek pickles is the use of "Gedelek Pinarbas,i Spring Water" rising in this region. The fact that Gedelek pickles maintain a texture hardness value close to industrial type pickles is related to the hard water feature of the water used. While local producers producing home-made fermented pickles are open to new products and techniques, they refrain from mechanisation and industrial production would taint the features and taste of pickles. Conscious production, training, institutional support, and promotion to be given to local producers without downgrading the local products would help these local pickles with a protected geographical indication convey the future generations.Item A Hybrid Monte Carlo Simulation Risk Model for Oil Exploration Projects(MARINE POLLUTION BULLETIN, 2023) Balas, Egemen AnderA new 3-D Hybrid Monte Carlo Simulation (MCS) Risk Model is proposed in this study. The wind, wave, current, climate change, and tsunami sub-models of the Three-Dimensional Hydrodynamic Transport and Water Quality Model HYDROTAM-3D are interrelated with MCS, to obtain probability distributions for the simulation of environmental conditions. This is the only model that can incorporate the tsunami, storm, and sea level rise risks in oil exploration projects. The spill risk index (SRI) of 50 blue barrels spilled due to a blowout from the rig/port during fuel supply was circa 1 ton/ship as Tier I with an average annual occurrence probability of 1.0 x 10-6. The discharge of 4000 bbls for 6 h was modeled, resulting in the SRI of 546 metric tons from the riser blowout with SRI = 0.2 per meter, indicating a Tier II risk. The mean arrival time of this spill was found by MCS as 145 min.Item A Multi-Objective Optimization Framework for Functional Arrangement in Smart Floating Cities(EXPERT SYSTEMS WITH APPLICATIONS, 2024) Kirimtat, Ayca; Tasgetiren, M. Fatih; Krejcar, Ondrej; Buyukdagli, Ozge; Maresova, PetraBefore the terms "smart city" and "floating city" were introduced, the world's population had increased and land shortage across the world was already widely recognized. As a first challenge, the previous studies have developed the concept of a smart city as a creative answer, following that, several scientists proposed the floating city concept in the literature as a solution to the increased sea levels. Moreover, engineers, architects, and designers deal with city planning, for smart and floating settlements as a difficult design challenge, and evolutionary algorithms could be employed to address this complex problem by optimizing residents' needs. As a continuation of our previous studies on this topic, this time, we develop a multi-objective continuous genetic algorithm with differential evolution (DE) mutation strategy (MO_CGADE) and a multi-objective ensemble differential evolution algorithm (MO_EDE) to solve the problem on hand. Then, we compare the performance of the MO_CGADE and MO_EDE algorithms with the non-dominated sorting genetic algorithm (NSGAII) to maximize two conflicted objective functions, namely, scenery, and walkability in the proposed smart floating city model created in the Grasshopper Algorithmic Modeling Environment. The parametric model that we create in the Grasshopper software includes 64 decision variables, area constraints and objective functions to be optimized by MO_CGADE, MO_EDE, and NSGAII algorithms. Computational results show that MO_CGADE and MO_EDE algorithms generate better Pareto ranking results than the traditional NSGAII algorithm in terms of cardinality, distribution spacing, and coverage metrics.Item A Partial Epithelial-Mesenchymal Transition Signature For Highly Aggressive Colorectal Cancer Cells That Survive Under Nutrient Restriction(JOURNAL OF PATHOLOGY, 2024-01-24) Pastorino, Gil A.; Sheraj, Ilir; Oral, Goksu; Gulec Taskiran, Aliye Ezgi; Palmisano, Ralph; Schneider-Stock, ReginePartial epithelial-mesenchymal transition (p-EMT) has recently been identified as a hybrid state consisting of cells with both epithelial and mesenchymal characteristics and is associated with the migration, metastasis, and chemoresistance of cancer cells. Here, we describe the induction of p-EMT in starved colorectal cancer (CRC) cells and identify a p-EMT gene signature that can predict prognosis. Functional characterisation of starvation-induced p-EMT in HCT116, DLD1, and HT29 cells showed changes in proliferation, morphology, and drug sensitivity, supported by in vivo studies using the chorioallantoic membrane model. An EMT-specific quantitative polymerase chain reaction (qPCR) array was used to screen for deregulated genes, leading to the establishment of an in silico gene signature that was correlated with poor disease-free survival in CRC patients along with the CRC consensus molecular subtype CMS4. Among the significantly deregulated p-EMT genes, a triple-gene signature consisting of SERPINE1, SOX10, and epidermal growth factor receptor (EGFR) was identified. Starvation-induced p-EMT was characterised by increased migratory potential and chemoresistance, as well as E-cadherin processing and internalisation. Both gene signature and E-cadherin alterations could be reversed by the proteasomal inhibitor MG132. Spatially resolving EGFR expression with high-resolution immunofluorescence imaging identified a proliferation stop in starved CRC cells caused by EGFR internalisation. In conclusion, we have gained insight into a previously undiscovered EMT mechanism that may become relevant when tumour cells are under nutrient stress, as seen in early stages of metastasis. Targeting this process of tumour cell dissemination might help to prevent EMT and overcome drug resistance. (c) 2024 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.Item A Performance Evaluation Study of Thin-Wall Tube Design in the Front Bumper Uses The Altered TOPSIS-Rank Order Clustering Algorithm-Integrated Approach(MULTISCALE AND MULTIDISCIPLINARY MODELING EXPERIMENTS AND DESIGN, 2024)Abstract The rising growth of the economy in developing countries led to a significant increase in the number of vehicles on the roads. The number of vehicles in road transport is also increasing significantly due to the increase in automobile ownership due to the increase in city populations. As a result of this increase, there is an increase in traffic accidents. For this reason, automobile manufacturers make significant efforts to develop lighter and more robust bumpers. Also, they used performance measurement studies for the thin-walled bumpers. The motivation of the study is based on the examines the dynamic performance of thin-walled bumpers within the impact of both oblique and axial compression. The crash performance of thin-wall tubes is analyzed based on factors such as speed, mass, and cross-section geometries. We developed a new rank order clustering (ROC) algorithm that integrated altered technique for order preferences by similarity to ideal solution (A-TOPSIS) method-based comparative analysis to determine the best thin-wall tube among the alternatives. For the first time in the literature, the A-TOPSIS results-integrated ROC algorithm is proposed to obtain the best tube profiles considering different expectations from their performance according to the determined criteria.Please check and confirm the edi t in the article title.OK.Please confirm if the author names are presented accurately and in the correct sequence (given name, middle name/initial, family name). Author 2 Given name: [Yusuf Tansel] Last name [Ic] and Author 4 Given name: [Bekir Batuhan] Last name [Sagol]. Also, kindly confirm the details in the metadata are correct.OKItem A. Lazer ve Isik Sistemleri(2020) Ozcan, HamdiLaser and light systems are being used and demanded by patients more and more everyday in the treatment of acne and scars. Various devices are used in active acne and scar treatment. The effects of light systems on acne and scar tissue have been reported in different magnitudes. Since there are differences in practice and methodology, no judgement can be made on the success of treatment methods. The effectiveness of light systems increases with combined therapies. Their use in combination with medical therapies may increase the rate of success.