Eczacılık Fakültesi / Faculty of Pharmacy

Permanent URI for this collectionhttps://hdl.handle.net/11727/5700

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    Green Hplc Method For Simultaneous Determination Of N-Acetylcysteine And L-Ascorbic Acid In Co-Formulated Pharmaceutical Products
    (JOURNAL OF RESEARCH IN PHARMACY, 2024-10-02) Ozen, Gurkan; Nemutlu, Emirhan
    It is difficult to analyze different concentrations of pharmaceutical active substances in dosage forms simultaneously, especially in formulations containing high amounts of excipients, on environmentally friendly principles without the need for any intervention. This study proposes a powerful analytical method for the simultaneous determination of L-ascorbic Acid and N- Acetyl Cysteine in an effervescent tablet using high performance liquid chromatography technique. In the study, it was aimed to reduce the use of toxic solvents/chemicals and waste emissions, to increase efficiency and to reduce the negative environmental consequences that may arise from them. The method was developed using a C18 (ACE-121-2546, 4.6 x 250 mm, 5 mu m) column and a sodium dihydrogen phosphate buffer mobile phase. Detection wavelengths were taken as 210 and 240 nm while the flow rate was 1 mL/min. The linearity, accuracy and precision, selectivity, sensitivity, and robustness of the proposed method were validated using International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use Q2R criteria and its green assessment was validated by AGREE and AGREEprep applications. The linear range was taken as 0.1-100 mu g/mL for both compounds analyzed in the developed method. The detection limit of the method was 0.02 and 0.04 mu g/mL respectively for L-ascorbic Acid and N- Acetyl Cysteine. The recovery of the method was between 98.75%102.20% and the accuracy and precision of the method for all compounds were 0.17% and 0.11% respectively. This new environmentally friendly method can be easily used by the chemical and pharmaceutical industries for regular analysis without any restrictions.
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    Combination Of Miniature Electrode Systems Via Nanomaterials: Pesticide Analysis
    (Başkent Üniversitesi Fen Bilimleri Enstitüsü, 2024-12) Celik, Murat; Kucuk, Ipek; Sadak, Selenay; Uslu, Bengi
    Pesticides are vital in modern agriculture for controlling pests and diseases, thereby enhancing crop yields and food security. However, their extensive use has raised environmental and health concerns due to their persistence and toxicity. Conventional detection methods, such as high-performance liquid chromatography and gas chromatography, are effective but often costly and time-consuming, prompting the need for alternative approaches. Electrochemical methods emerge as promising solutions for pesticide analysis owing to their affordability, simplicity, and suitability for field applications. The incorporation of nanomaterials into electrochemical sensors significantly enhances their sensitivity and selectivity. Nanomaterials, including noble metals, carbon nanotubes, and metal oxide nanoparticles, improve sensor performance through their unique physical, chemical, and biological properties. This review examines recent advancements in miniature electrochemical sensors for pesticide detection, including contemporary literature. It discusses the structure, applications, and impacts of pesticides, and highlights the advantages of electrochemical sensors enhanced by nanomaterials. Various electrode types and their modifications with nanomaterials are evaluated. Additionally, the integration of smartphone technology and innovative approaches such as lab-on-a-chip and portable sensors are explored. By incorporating recent studies, this review provides a comprehensive reference for developing advanced, portable, and in situ analyzers utilizing nanomaterials, aiming to enhance food safety, human health, and environmental monitoring.