Eczacılık Fakültesi / Faculty of Pharmacy

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    Combination Of Miniature Electrode Systems Via Nanomaterials: Pesticide Analysis
    (Başkent Üniversitesi Fen Bilimleri Enstitüsü, 2024-12) Celik, Murat; Kucuk, Ipek; Sadak, Selenay; Uslu, Bengi
    Pesticides are vital in modern agriculture for controlling pests and diseases, thereby enhancing crop yields and food security. However, their extensive use has raised environmental and health concerns due to their persistence and toxicity. Conventional detection methods, such as high-performance liquid chromatography and gas chromatography, are effective but often costly and time-consuming, prompting the need for alternative approaches. Electrochemical methods emerge as promising solutions for pesticide analysis owing to their affordability, simplicity, and suitability for field applications. The incorporation of nanomaterials into electrochemical sensors significantly enhances their sensitivity and selectivity. Nanomaterials, including noble metals, carbon nanotubes, and metal oxide nanoparticles, improve sensor performance through their unique physical, chemical, and biological properties. This review examines recent advancements in miniature electrochemical sensors for pesticide detection, including contemporary literature. It discusses the structure, applications, and impacts of pesticides, and highlights the advantages of electrochemical sensors enhanced by nanomaterials. Various electrode types and their modifications with nanomaterials are evaluated. Additionally, the integration of smartphone technology and innovative approaches such as lab-on-a-chip and portable sensors are explored. By incorporating recent studies, this review provides a comprehensive reference for developing advanced, portable, and in situ analyzers utilizing nanomaterials, aiming to enhance food safety, human health, and environmental monitoring.
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    Sensor-based MIP technologies for targeted metabolomics analysis
    (2022) Ozcelikay, G.; Kaya, S., I; Ozkan, E.; Cetinkaya, A.; Nemutlu, E.; Kir, S.; Ozkan, S.A.
    In recent years, metabolomics, identification and profiling of metabolites, have gained broad interest compared to other omics technologies and are progressively being utilized for biomarker discoveries. Therefore, the application of metabolomics in different fields are increasing day by day because of its high throughput results. However, the application of metabolomics requires state-of-the-art analytical approaches for the analysis. The complexity and limited availability of these instruments are restricting parameters for applying metabolomics studies in routine analysis. This problem may be overcome with molecularly imprinted polymer (MIP)-based electro sensors since they have high selectivity, sensitivity, easy applicability, portability, and low cost. This is the final step before developing end point-of-care tests (POCT), which patients can easily apply. MIP sensors will have more applications in the targeted metabolomics analysis to develop POCT systems. This review analyzes various metabolites using MIP-based electrochemical methods for their potential usage as POCT and biomarker research based on targeted metabolomics analysis requirements. The future applications for the sensitive assay of metabolites in medicine and clinical trials are also discussed. (C) 2021 Elsevier B.V. All rights reserved.