Eczacılık Fakültesi / Faculty of Pharmacy

Permanent URI for this collectionhttps://hdl.handle.net/11727/5700

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Author: search.filters.author.Pehlivanli, Aysel

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    An Essential Problem in Antimicrobial Stewardship: Multi-Drug-Resistant Gram-Negative Bacterial Infection in the Intensive Care Unit
    (Başkent Üniversitesi, 2024-02-01) Pehlivanli, Aysel; Ozgun, Cigdem; Yuksel, Didem; Solmaz, Firdevs Gonca Sasal; Ozcelikay, Arif Tanju; Unal, Mustafa Necmettin
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    The Impact of Clinical Pharmacist in Geriatric Drug-Related Problems: A Scoping Review
    (Başkent Üniversitesi, 2024-02-01) Ediz, Cigdem; Bicer, Asim Emre; Pehlivanli, Aysel; Basgut, Bilgen; Ozcelikay, Arif Tanju
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    Pharmacy Practice And Policy Research In Türkiye: A Systematic Review Of Literature
    (JOURNAL OF PHARMACEUTICAL POLICY AND PRACTICE, 2024-12-31) Gulpinar, Gizem; Pehlivanli, Aysel; Babaar, Zaheer Ud-Din
    BackgroundIn recent decades, there has been an interest in clinical pharmacy practice in T & uuml;rkiye with emerging studies in this area. Despite the recent emergence of diverse pharmacy practice studies in T & uuml;rkiye, a comprehensive assessment of overall typology of studies and impact has not been conducted thus far.ObjectivesThis systematic review aims to document and assess pharmaceutical policy and practice literature published within the last 5 years in T & uuml;rkiye. The other aim is to summarise the expected impact of published studies on policy and practice research.MethodsThe systematic review was conducted according to the guidelines described in the PRISMA Statement. A comprehensive search approach, incorporating Medical Subject Headings (MeSH) queries and free-text terms was employed to locate pertinent literature related to pharmacy practice and policy in T & uuml;rkiye. The search covered the period from January 1, 2019, to January 1, 2024, and involved electronic databases including PubMed, Medline Ovid, Scopus, ScienceDirect, Springer Link, PlosOne, and BMC.ResultsIn the final grouping, 73 articles met the inclusion criteria and were selected for this review. Among the quantitative studies, majority studies were cross-sectional survey studies. Through the rigorous thematic content analysis seven research domains were developed from the selected literature: drug utilisation and rational drug use, the emerging role of pharmacist, access to medicines and generic medicines, community pharmacy practice, pharmacovigilance/adverse drug reactions, and pharmacoeconomic studies.ConclusionsThe pharmacist role is evolving; however, several challenges remain in fully realising the potential of pharmacists. These include regulatory barriers, limited public awareness of pharmacists' expanded roles, workforce capacity issues, and the need for ongoing professional development and training. Research studies are needed in the areas of generic prescribing, medicine adherence, intervention studies in community and hospital pharmacy practice, and on pharmacoeconomics and pharmacovigilance.
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    Potential drug-drug interactions of immunosuppressants in kidney transplant recipients: comparison of drug interaction resources
    (2022) Pehlivanli, Aysel; Eren-Sadioglu, Rezzan; Aktar, Merve; Eyupoglu, Sahin; Sengul, Sule; Keven, Kenan; Erturk, Sehsuvar; Basgut, Bilgen; Ozcelikay, Arif Tanju; 35235113
    Background Drug-drug interactions are frequently observed in kidney transplant recipients due to polypharmacy and use of immunosuppressants. However, there is only one study evaluating clinically relevant potential drug-drug interactions of immunosuppressants specially in kidney transplant recipients by means of online databases and Stockleys Drug Interactions, as a gold standard. Aim This study aimed to compare four online databases used frequently to determined clinically relevant potential drug-drug interactions of immunosuppressants in kidney transplant recipients according to the Renal Drug Handbook. Method This was a descriptive cross-sectional study conducted between October 1, 2019, and March 18, 2020, in the nephrology ward of Ankara University School of the Medicine, Ibn-i Sina Hospital. In total, 52 adult patients' discharge prescriptions were retrieved from their medical records and analyzed retrospectively. Micromedex (R), Lexicomp (R), Medscape, and Drugs.com databases were used to evaluate drug interactions. The Renal Drug Handbook was used as a gold standard to do specificity and sensitivity analysis. Results A total of 127 potential drug-drug interactions between the immunosuppressants and co-medications were detected by at least one online database. 32 (25.2%) of these were approved as clinically relevant potential drug-drug interactions by the Renal Drug Handbook. Lexicomp (R) and Drugs.com have exhibited the highest sensitivity (0.72 and 0.75) while Micromedex (R) has shown the highest specifity (0.83). Furthermore, the highest positive predictive value has been observed in Micromedex (R) (0.53). Micromedex (R) and Medscape had the highest negative predictive value (0.83 and 0.82). However, the kappa value of all was low. The values of inter-rater agreement (Kappa index) between online databases and the Renal Drug Handbook were weak (range 0.05-0.36). In addition, only 11 (8.7%) of potential drug-drug interactions were identified by all online databases. Conclusion This study showed that there was a weak compatibility between each database examined and the Renal Drug Handbook to detect clinically relevant potential drug-drug interactions for immunosuppressants in kidney transplant recipients. Therefore, we suggest that although databases might be practical to take a quick glance in detection of potential drug-drug interactions between immunosuppressants and co-medications, the data should be evaluated in detail and interpreted with caution in combination with a reference book like Renal Drug Handbook.