TR-Dizin Kapalı Erişimli Yayınlar

Permanent URI for this collectionhttps://hdl.handle.net/11727/10757

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Author: search.filters.author.Aydingoz, Selda Emresearch.filters.applied.f.language: search.filters.language.eng

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    Reporting quality of animal studies published in journals listed in ULAKBIM TR index: a systematic review on compliance to the ARRIVE guidelines
    (2022) Aydingoz, Selda Emre; Efe, Oguzhan Ekin; Caliskan, Gokce; 0000-0001-7823-7620; 0000-0002-3243-7843; ABA-4291-2020; W-7908-2019
    Transparent reporting of animal studies is key to ensure reproducibility. The primary guideline for reporting animal studies is the ARRIVE (Animal Research: Reporting of In Vivo Experiments). We aimed to evaluate the compliance to the updated ARRIVE guidelines (version 2.0, date 2020) in animal studies published in journals indexed by the Turkish Academic Network and Information Centre (ULAKBIM TR Index). This was a retrospective analysis of reporting quality of animal studies published in journals listed in ULAKBIM TR Index between January 2010 and August 2021. The percentage of articles that fully reported each " of the ARRIVE Essential 10: Compliance Questionnaire was calculated, and effects of journal- and article-related factors were evaluated. Totally, 235 articles published in 89 journals were included into the analysis. The mean percentage of fully reported items was 59.1%+/- 10.9%, the least reported items being those related with bias - "blinding", "allocation to study groups", "assessment of statistical assumptions", "excluded animals", and "sample size calculation" (0.9%-10.6%). The journal's publisher, frequency, language, being indexed in the Science Citation Index Expanded, and the ratio of animal studies had no significant effect on this percentage (p>0.05). However, journals supporting the ARRIVE guidelines had significantly and higher compliance (62.1 %+/- 10.1% vs. 58.2%+/- 11.0% for supporters and non-supporters, respectively; p=0.017, 95%CI -7.0 to-0.7). Articles published after 2015 had higher compliance to the ARRIVE guidelines than those published previously (60.9%+/- 10.4% vs. 57.9%+/- 11.1%, respectively; p=0.037, 95%CI -5.8 to -0.2). Although progress has been made, compliance to the ARRIVE guidelines is still low in animal studies published in journals listed in ULAKBIM TR Index-Turkey's scientific journal database that covers over 800 peer-review journals. In order to increase the reporting quality and reproducibility of animal studies, it is imperative to raise awareness among researchers and journals, and to enforce the ARRIVE guidelines in editorial policy of journals.
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    Effects of Algan Hemostatic Agent on bleeding time in a rat tail hemorrhage model
    (2020) Totuk, Ozgan Melike Gedar; Guzel, Sevket Ergun; Ekici, Husamettin; Kumandas, Ali; Aydingoz, Selda Emre; Yilmaz, Enis Cagatay; Kirdan, Taylan; Midi, Ahmet; 0000-0001-7823-7620; 33107963; ABA-4291-2020
    BACKGROUND: Algan Hemostatic Agent (AHA) is a multi-herbal extract containing a standardized amount of Achillea millefolium, Juglans regia, Lycopodium clavatum, Rubus caesius or Rubis fruciosus, Viscum album, and Vitis vinifera, each of which is effective in hemostasis. In this study, we aimed to investigate the effects of AHA on bleeding time in a rat tail hemorrhage model. METHODS: Forty-eight Sprague Dawley rats (5-7 weeks old, 180-210 g) were randomly and equally allocated to six groups as follows: heparin plus saline (heparinized control), heparin plus AHA-soaked sponge, heparin plus liquid form of AHA, saline (non-heparinized control), AHA-soaked sponge and liquid form of AHA. Heparin (640 IU/kg) was administered intraperitoneally three times a day for three days in heparinized groups. For the bleeding model, the tail of rats was transected. According to the study group, either saline- or AHA-soaked sponge or liquid form of AHA was applied over the hemorrhage area. In AHA- or saline-soaked sponge groups, once the bleeding time had started, it was checked every 10 seconds. If the bleeding did not stop after 40 seconds, it was accepted as a failure. In liquid AHA group, the duration of bleeding was measured using a chronometer and defined as the time (seconds) from wounding until the bleeding stopped. RESULTS: Bleeding time in the heparinized and non-heparinized control groups was over 40 seconds. After applying the sponge form of AHA on the wound area, bleeding time was significantly shortened to less than 20 seconds in both heparinized and non-heparinized rats (p<0.001 for both). The liquid form of AHA stopped bleeding in 5.0 +/- 1.2 seconds and 8.0 +/- 1.3 seconds in heparinized and non-heparinized groups, respectively. CONCLUSION: AHA is a highly effective topical hemostatic agent in a rat tail hemorrhage model, thus may provide for a unique clinically effective option for control of bleeding during surgical operations or other emergencies.