Wos Açık Erişimli Yayınlar

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    Evaluation of Choroidal Thickness Using Spectral-Domain Optical Coherence Tomography in Patients with Severe Obstructive Sleep Apnea Syndrome: A Comparative Study
    (2014) Karalezli, Aylin; Eroglu, Fatma Corak; Kivanc, Tulay; Dogan, Rasina; https://orcid.org/0000-0003-3003-0756; 25540760; D-5308-2015
    AIM: To assess choroidal thickness in patients with severe obstructive sleep apnea syndrome (OSAS) and compare them with healthy controls, using spectral domain optical coherence tomography (OCT). METHODS: In this observational, cross-sectional study, choroidal thicknesses of 23 newly severe OSAS patients and 23 body mass index- age- and sex-matched healthy subjects were measured using a high -speed, high resolution frequency domain-OCT device (lambda=840 nm, 26 000 A -scans/s, 5 pm axial resolution). All patients underwent a complete ophthalmic examination before the measurements. OCT measurements were taken at the same time of day (9:00 a.m.), in order to minimize the effects of diurnal variation. RESULTS: There was a statistically significant difference in median choroidal thickness between the OSAS patients (201 pm; range 145 -237 pm) and the controls (324 pm; range 296 -383 mu m; P <0.001). There were significant differences at all measurement points (P <0.001 for all). The apnea -hypopnea index (AHI) values were more than 30 in all OSAS patients and the mean AHI was 48.57 +/- 6.54. The interexaminer intraclass correlation coefficient (ICC) for the mean choroidal thickness was 0.938 (95%CI, 0.908-0.985) and ICC was greater than 0.90 for all measurement points. CONCLUSION: The decreased choroidal thickness of patients with severe OSAS might be related to the the autonomic disregulation associated with this disease. Further studies are needed to evaluate the etiopathologic relationship between choroidal thickness and OSAS.
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    Coexistence of Familial Mediterranean Fever and Hyperimmunoglobulinemia D Syndrome in a Child
    (2015) Yilmaz, Resul; Sezer, Taner; Esmeray, Haluk; 0000-0001-7672-8100; 0000-0002-2278-1827; A-2825-2012; AAJ-5931-2021
    Hereditary periodic fever syndromes are Mendelian inherited single gene diseases which are also known as hereditary autoinflammatory syndromes, are characterized by recurrent attacks of fever and inflammation. Familial Mediterranean Fever and Hyperimmunoglobulinemia D syndrome are prototypes and are inherited autosomal recessively. The diagnosis is based on clinical course, family history and is confirmed with genetic mutation analysis. We describe a 5-year-old boy who had recurrent attacks of fever, skin rash, and cervical lymphadenopathy since he was 2 years old. His genetic analysis revealed homozygous M694V and V377I for MEFV and MVK gene respectively. Due to our knowledge, this is the first report of a patient who has both HIDS and FMF clinical and genetic features.
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    Giant but Silent Lesion of the Stomach in A Geriatric Patient
    (2016) Etik, Digdem Ozer; Tumay, Volkan; Aktas, Hikmet; Meric, Mehmet; Zorluoglu, Abdullah; 0000-0002-6206-9332; 0000-0002-4724-0728; 27782902; A-2109-2019; AAJ-4707-2021
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    The Approach to Community-Acquired Pneumonia: A Survey Study
    (2018) Ozyurek, Berna Akinci; Erturk, Arzu; Aydemir, Yusuf; Sen, Nazan; Alizoroglu, Dursun; Ozhan, Mustafa Hikmet; https://orcid.org/0000-0002-4171-7484; AAI-8947-2021
    INTRODUCTION AND AIM: Community-acquired pneumonia (CAP), which is often seen in daily practice, is a lower respiratory tract and pulmonary parenchyma infection which develops in society and daily life with community-acquired pathogens in individuals with no known immune failure. Delay in the treatment of pneumonia is known to increase morbidity and mortality. Various scoring systems are currently used in the identification of treatment groups in pneumonia. With the aim of evaluating the approach to CAP cases, the infection. MATERIALS AND METHODS: Working Group of the Turkish Respiratory Research Association (TUSAD) prepared a 22-item questionnaire. RESULTS: The survey was published on the TUSAD official website between July 2013 and June 2016. A total of 78 individuals responded to the questionnaire on the website. CONCLUSION: The responses to the questionnaire could indicate the way forward for new guidelines for physicians in respect of the approach to CAP.
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    Comparable Survival Using A CMV-Matched Or A Mismatched Donor For CMV Plus Patients Undergoing T-Replete Haplo-HSCT With PT-Cy For Acute Leukemia: A Study Of Behalf Of The Infectious Diseases And Acute Leukemia Working Parties Of The EBMT
    (2018) Cesaro, Simone; Crocchiolo, Roberto; Tridello, Gloria; Knelange, Nina; Van Lint, Maria Teresa; Koc, Yener; Ciceri, Fabio; Gulbas, Zafer; Tischer, Johanna; Afanasyev, Boris; Bruno, Benedetto; Castagna, Luca; Blaise, Didier; Mohty, Mohamad; Irrera, Giuseppe; Diez-Martin, J. L.; Pierelli, Luca; Pioltelli, Pietro; Arat, Mutlu; Delia, Mario; Fagioli, Franca; Ehninger, Gerhard; Aljurf, Mahmoud; Carella, Angelo Michele; Ozdogu, Hakan; Mikulska, Malgorzata; Ljungman, Per; Nagler, Arnon; Styczynski, Jan; https://orcid.org/0000-0002-8902-1283; 29330396; AAD-5542-2021
    The role of donor CMV serostatus in the setting of non T-cell depleted haplo-HSCT with post-transplant cyclophosphamide (PT-Cy) has not been specifically addressed so far. Here we analyzed the impact of the donor CMV serological status on the outcome of 983 CMV seropositive (CMV+), acute leukemia patients receiving a first, non T-cell depleted haplo-HSCT registered in the EBMT database. The 1-year NRM was 21.3% (95% CI: 18.4-24.8) and 18.8% (95% CI: 13.8-25.5) in the CMV D+P/R+ and D-/R+ pairs, respectively (p = 0.40). Similarly, 1-year OS was 55.1% (95% CI: 50.1-58.0) and 55.7% (95% CI: 48.0-62.8) in the same groups (p = 0.50). The other main outcomes were comparable. No difference in NRM nor OS was observed after stratification for the intensity of conditioning and multivariate anaysis confirmed the lack of significant association with NRM or OS. In conclusion, the choice of a CMV-seronegative donor did not impair early survival of CMV-seropositive patients with acute leukemia after a first, non T-cell depleted haploidentical HSCT and PT-Cy among this series of 983 consecutive patients. Future research may focus on the assessment of the hierarchy of all the donor variables.
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    Polytrauma in the Geriatric Population: Analysis of Outcomes for Surgically Treated Multiple Fractures with a Minimum 2 Years of Follow-Up
    (2022) Sahin, Orcun; https://orcid.org/0000-0002-6035-6258; 35294739; AAF-4032-2021
    Introduction This study analyzed the clinical and radiological outcomes of geriatric polytrauma patients who had multiple fractures surgically treated and a minimum of 2 years of follow-up. Methods Eighty-six geriatric patients with polytrauma and multiple fractures which were surgically treated in orthopedics and who had a minimum of 2 years of follow-up were retrospectively analyzed. Patients' demographic characteristics, comorbidities, and follow-up time were recorded. The mechanism of injury, fracture type and location, Injury Severity Score (ISS), American Society of Anesthesiologists (ASA) score, duration of hospital stay, complications, and 1-year mortality were also recorded. Fracture union, implant failure, and refractures/misalignment were analyzed from radiographs. Results There were 34 (39.5%) male and 52 (60.5%) female patients. Mean age was 73.5 years with an average follow-up time of 32.9 months. Patients had more low-energy traumas and more lower extremity, comminuted fractures. On the contrary, high-energy traumas and femur/pelvic fracture surgeries had higher associated mortality. The mean ISS score was 26.3. The most common ASA score was ASA 3 (75.8%). The most common clinical and radiological complications were prolonged wound drainage and implant failure. The total 1-year mortality rate was 22.1%. Patients with high ASA scores and patients with lower extremity fractures (femoral/pelvic fractures) also had significantly increased mortality rates. No significant relation was detected between mortality and ISS, fracture type, number of fractures, and duration of hospital stay. Conclusion Orthopedic surgeons must be alert about the possible complications of femoral fractures and comminuted fractures including pelvic girdle. Surgically treated, multifractured patients with high-energy trauma, advanced age, and high ASA scores are also at risk for mortality regardless of the ISS, comorbidities, and duration of hospital stay. Pulmonary thromboemboli must be kept in mind as a significant complication for mortality.
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    The People's Republic of China In Africa
    (2022) Karadag, Haluk; Ozerdem, A; Akgul-Acikmese, S; Liebenberg, I
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    Atypical Glandular Cells in Papanicolaou Test: Which is More Important in The Detection of Malignancy, Architectural or Nuclear Features?
    (2021) Yucel Polat, Aysegul; Tepeoglu, Merih; 0000-0002-3590-9375; 0000-0002-9894-8005; 33606313; AAP-3975-2021; AAK-5222-2021
    Objective Atypical glandular cells (AGCs) in Pap (Papanicolaou) smears are uncommon but may represent various benign and malignant lesions. The aim of this study was to evaluate the AGC incidence in Pap smears, analyse the relationship between AGC and malignancy, and reveal the importance of architectural and nuclear features observed cytologically in malignancies. Methods Patients diagnosed with AGC on the basis of cervicovaginal cytology between May 2011 and July 2018 were included in this study. All slides were retrospectively reviewed and subclassified according to the Bethesda 2001 classification system. The cytomorphological features observed in the smears were recorded. Cytohistological correlations were evaluated, and the significant clinicopathological findings for malignancy were determined. Results Of 87 536 Pap smears, 195 (0.22%) had AGC results and 156 had tissue follow-up. Among the 156 smears with AGC, 80 (51.3%) were diagnosed as AGC-NOS (atypical glandular cells, not otherwise specified) and 76 (48.7%) as AGC-FN (atypical glandular cells, favour neoplastic). Follow-up biopsies revealed benign pathologies in 49 cases (31.4%) and malignant pathologies in 107 (68.6%). The rate of malignancy observed in AGC-FN cases (89.5%) was higher than the rate of malignancy in AGC-NOS cases (48.8%). Among the cytomorphological features, nuclear irregularity, presence of macronucleoli, feathering, loss of polarity, papillary pattern, and three-dimensional formation were found to be significant indicators of malignancy. Conclusion As AGC in Pap smear was associated with a clinically significant diagnosis in 68.6% of the cases in our study, we suggest that all patients with AGC should undergo further clinical assessment.
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    Validity and Reliability Evidence of Professional Obsolescence Scale According to Different Test Theories
    (2021) Altun, Sedagul Akbaba; Buyukorturk, Sener; Seheryeli, Merve Yildirim
    This study aims to develop a scale that will determine the factors causing professional obsolescence in the field of education. In this context, the Professional Obsolescence Scale (POS) has been developed to determine the professional and organizational obsolescence of primary, secondary and high school administrators. In this scale development process, steps were followed in line with the suggestions of Crocker and Algina (2006) and Cronbach (1984). Firstly, 63 items were prepared and 991 school principals participated the study. R (version 4.0.1) software was used to analyze the data. Item and test parameters and information functions have been estimated using Samejima's Graded Response Model based on Item Response Theory. Principal Axis Analysis was performed for the construct validity of the scale, and four-dimensions structure with 47 items has been obtained. These dimensions are named as "Being Open to Professional Development", "Job-Ability Harmony in Profession", "Organizational Support in Professional Development", "Professional Burnout". The scores obtained from each dimension are evaluated within themselves. It has been observed that each dimension fulfills the conditions of unidimensionality, local independence, model-data fit and parameter invariance. According to the Classical Test Theory, Cronbach Alpha coefficients are between 0.807 and 0.945. The Stratified Alpha coefficient calculated for the whole scale is 0.94. According to the Item Response Theory, the marginal reliability coefficients were between 0.857 and 0.936 and the empirical reliability coefficients were found between 0.854 and 0.938.
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    Early Maxillary Expansion with the Ni-Ti Memory Leaf Expander-A Compliance-Free Fixed Slow Maxillary Expansion Screw: A Report of 2 Cases
    (2021) Ulug, Bahar; Ozcirpici, Ayca Arman; 35110164
    Transversal problems such as crowding and crossbite are one of the most common problems dealt with in early orthodontic treatments. Early correction of these problems may ease or even eliminate the future need for treatment. This paper presents the management of 2 cases with transverse discrepancy using the Ni-Ti Memory Leaf Expander-a new compliance-free slow maxillary expansion appliance. The total treatment time for both cases was 9 months. In both cases, the inter-canine, inter-premolar, and inter-molar distances, as well as the arch length, have all increased.