Wos Açık Erişimli Yayınlar
Permanent URI for this collectionhttps://hdl.handle.net/11727/10754
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Item Evaluation of Choroidal Thickness Using Spectral-Domain Optical Coherence Tomography in Patients with Severe Obstructive Sleep Apnea Syndrome: A Comparative Study(2014) Karalezli, Aylin; Eroglu, Fatma Corak; Kivanc, Tulay; Dogan, Rasina; https://orcid.org/0000-0003-3003-0756; 25540760; D-5308-2015AIM: To assess choroidal thickness in patients with severe obstructive sleep apnea syndrome (OSAS) and compare them with healthy controls, using spectral domain optical coherence tomography (OCT). METHODS: In this observational, cross-sectional study, choroidal thicknesses of 23 newly severe OSAS patients and 23 body mass index- age- and sex-matched healthy subjects were measured using a high -speed, high resolution frequency domain-OCT device (lambda=840 nm, 26 000 A -scans/s, 5 pm axial resolution). All patients underwent a complete ophthalmic examination before the measurements. OCT measurements were taken at the same time of day (9:00 a.m.), in order to minimize the effects of diurnal variation. RESULTS: There was a statistically significant difference in median choroidal thickness between the OSAS patients (201 pm; range 145 -237 pm) and the controls (324 pm; range 296 -383 mu m; P <0.001). There were significant differences at all measurement points (P <0.001 for all). The apnea -hypopnea index (AHI) values were more than 30 in all OSAS patients and the mean AHI was 48.57 +/- 6.54. The interexaminer intraclass correlation coefficient (ICC) for the mean choroidal thickness was 0.938 (95%CI, 0.908-0.985) and ICC was greater than 0.90 for all measurement points. CONCLUSION: The decreased choroidal thickness of patients with severe OSAS might be related to the the autonomic disregulation associated with this disease. Further studies are needed to evaluate the etiopathologic relationship between choroidal thickness and OSAS.Item Coexistence of Familial Mediterranean Fever and Hyperimmunoglobulinemia D Syndrome in a Child(2015) Yilmaz, Resul; Sezer, Taner; Esmeray, Haluk; 0000-0001-7672-8100; 0000-0002-2278-1827; A-2825-2012; AAJ-5931-2021Hereditary periodic fever syndromes are Mendelian inherited single gene diseases which are also known as hereditary autoinflammatory syndromes, are characterized by recurrent attacks of fever and inflammation. Familial Mediterranean Fever and Hyperimmunoglobulinemia D syndrome are prototypes and are inherited autosomal recessively. The diagnosis is based on clinical course, family history and is confirmed with genetic mutation analysis. We describe a 5-year-old boy who had recurrent attacks of fever, skin rash, and cervical lymphadenopathy since he was 2 years old. His genetic analysis revealed homozygous M694V and V377I for MEFV and MVK gene respectively. Due to our knowledge, this is the first report of a patient who has both HIDS and FMF clinical and genetic features.Item Giant but Silent Lesion of the Stomach in A Geriatric Patient(2016) Etik, Digdem Ozer; Tumay, Volkan; Aktas, Hikmet; Meric, Mehmet; Zorluoglu, Abdullah; 0000-0002-6206-9332; 0000-0002-4724-0728; 27782902; A-2109-2019; AAJ-4707-2021Item The Approach to Community-Acquired Pneumonia: A Survey Study(2018) Ozyurek, Berna Akinci; Erturk, Arzu; Aydemir, Yusuf; Sen, Nazan; Alizoroglu, Dursun; Ozhan, Mustafa Hikmet; https://orcid.org/0000-0002-4171-7484; AAI-8947-2021INTRODUCTION AND AIM: Community-acquired pneumonia (CAP), which is often seen in daily practice, is a lower respiratory tract and pulmonary parenchyma infection which develops in society and daily life with community-acquired pathogens in individuals with no known immune failure. Delay in the treatment of pneumonia is known to increase morbidity and mortality. Various scoring systems are currently used in the identification of treatment groups in pneumonia. With the aim of evaluating the approach to CAP cases, the infection. MATERIALS AND METHODS: Working Group of the Turkish Respiratory Research Association (TUSAD) prepared a 22-item questionnaire. RESULTS: The survey was published on the TUSAD official website between July 2013 and June 2016. A total of 78 individuals responded to the questionnaire on the website. CONCLUSION: The responses to the questionnaire could indicate the way forward for new guidelines for physicians in respect of the approach to CAP.Item Comparable Survival Using A CMV-Matched Or A Mismatched Donor For CMV Plus Patients Undergoing T-Replete Haplo-HSCT With PT-Cy For Acute Leukemia: A Study Of Behalf Of The Infectious Diseases And Acute Leukemia Working Parties Of The EBMT(2018) Cesaro, Simone; Crocchiolo, Roberto; Tridello, Gloria; Knelange, Nina; Van Lint, Maria Teresa; Koc, Yener; Ciceri, Fabio; Gulbas, Zafer; Tischer, Johanna; Afanasyev, Boris; Bruno, Benedetto; Castagna, Luca; Blaise, Didier; Mohty, Mohamad; Irrera, Giuseppe; Diez-Martin, J. L.; Pierelli, Luca; Pioltelli, Pietro; Arat, Mutlu; Delia, Mario; Fagioli, Franca; Ehninger, Gerhard; Aljurf, Mahmoud; Carella, Angelo Michele; Ozdogu, Hakan; Mikulska, Malgorzata; Ljungman, Per; Nagler, Arnon; Styczynski, Jan; https://orcid.org/0000-0002-8902-1283; 29330396; AAD-5542-2021The role of donor CMV serostatus in the setting of non T-cell depleted haplo-HSCT with post-transplant cyclophosphamide (PT-Cy) has not been specifically addressed so far. Here we analyzed the impact of the donor CMV serological status on the outcome of 983 CMV seropositive (CMV+), acute leukemia patients receiving a first, non T-cell depleted haplo-HSCT registered in the EBMT database. The 1-year NRM was 21.3% (95% CI: 18.4-24.8) and 18.8% (95% CI: 13.8-25.5) in the CMV D+P/R+ and D-/R+ pairs, respectively (p = 0.40). Similarly, 1-year OS was 55.1% (95% CI: 50.1-58.0) and 55.7% (95% CI: 48.0-62.8) in the same groups (p = 0.50). The other main outcomes were comparable. No difference in NRM nor OS was observed after stratification for the intensity of conditioning and multivariate anaysis confirmed the lack of significant association with NRM or OS. In conclusion, the choice of a CMV-seronegative donor did not impair early survival of CMV-seropositive patients with acute leukemia after a first, non T-cell depleted haploidentical HSCT and PT-Cy among this series of 983 consecutive patients. Future research may focus on the assessment of the hierarchy of all the donor variables.Item T1 Mapping by Cardiac Magnetic Resonance and Multidimensional Speckle-Tracking Strain by Echocardiography for the Detection of Acute Cellular Rejection in Cardiac Allograft Recipients(2019) Sade, Leyla Elif; Hazirolan, Tuncay; Kozan, Hatice; Ozdemir, Handan; Hayran, Mutlu; Eroglu, Serpil; Pirat, Bahar; Sezgin, Atilla; Muderrisoglu, Haldun; 29680337; X-8540-2019OBJECTIVES The aim of this study was to test the hypothesis that echocardiographic strain imaging, by tracking subtle alterations in myocardial function, and cardiac magnetic resonance T1 mapping, by quantifying tissue properties, are useful and complement each other to detect acute cellular rejection in heart transplant recipients. BACKGROUND Noninvasive alternatives to endomyocardial biopsy are highly desirable to monitor acute cellular rejection. METHODS Surveillance endomyocardial biopsies, catheterizations, and echocardiograms performed serially according to institutional protocol since transplantation were retrospectively reviewed. Sixteen-segment global longitudinal strain (GLS) and circumferential strain were measured before, during, and after the first rejection and at 2 time points for patients without rejection using Velocity Vector Imaging for the first part of the study. The second part, with cardiac magnetic resonance added to the protocol, served to validate previously derived strain cutoffs, examine the progression of strain over time, and to determine the accuracy of strain and T1 measurements to define acute cellular rejection. All tests were performed within 48 h. RESULTS Median time to first rejection (16 grade 1 rejection, 15 grade >= 2 rejection) was 3 months (interquartile range: 3 to 36 months) in 49 patients. GLS and global circumferential strain worsened significantly during grade 1 rejection and >= 2 rejection and were independent predictors of any rejection. In the second part of the study, T1 time >= 1,090 ms, extracellutar volume GLS >= 32%, GLS >-14%, and global circumferential strain >=-24% had 100% sensitivity and 100% negative predictive value to define grade >= 2 rejection with 70%, 63%, 55%, and 35% positive predictive values, respectively. The combination of GLS > 16% and T1 time >= 1,060 ms defined grade 1 rejection with 91% sensitivity and 92% negative predictive value. After successful treatment, T1 times decreased significantly. CONCLUSIONS T1 mapping and echocardiographic GLS can serve to guide endomyocardial biopsy selectively. (C) 2019 by the American College of Cardiology Foundation.Item Acute effects of exercise on choroidal thickness and ocular pulse amplitude(2019) Dervisogulları, Mehmet Serdar; Totan, Yuksel; Kulak, Ali Ender; Guler, Emre; 0000-0003-2006-2906; G-7851-2015Aim: To explore ocular changes in healthy people after exercise. Material and Method: Twenty participants underwent exercise for 15 minutes on a treadmill. Measurements of choroidal thickness, intraocular pressure (IOP), ocular pulse amplitude (OPA), and blood pressure were taken before and after exercise. Enhanced Depth, Imaging optical coherence tomography (EDI-OCT) was used to measure choroidal thickness at the fovea and at the areas 1500 mu m nasal and 1500 mu m temporal to the fovea; IOP and OPA were measured by the dynamic contour tonometer (DCT; Swiss Micro technology AG, Port, Switzerland). Blood pressure was measured concurrently with the acquisition of the scans. Results: Twenty participants (20 eyes) with a mean age of 22.65 +/- 0.98 years were measured. There was a significant increase in systolic and diastolic pressure after exercise (p<0.05). There was a significant decrease in IOP and OPA after exercise (p<0.05). There was no significant difference in the subfoveal, nasal or temporal choroidal thickness measurements after exercise (p>0.05). Discussion: In our study, there was no significant change in the thickness of the choroid after exercise. IOP and OPA significantly decreased, and systolic and diastolic blood pressure significantly increased, after exercise. This indicates an adaptation of vascular resistance due to vasoconstriction. The IOP and OPA decreases do not seem to be related with the changes in choroid thickness.Item Covering the More Visible Region by Electrochemical Copolymerization of Carbazole and Benzothiadiazole Based Donor-Acceptor Type Monomers(2019) Cansu-Ergun, Emine Gul; 0000-0002-3941-4345; I-7385-2017An electrochromic copolymer film of 2-(3,3-dihexyl-3,4-dihydro-2H-thieno[3,4-b][1,4]dioxepin-6-yl)-7-(3,3-dihexyl-3,4-dihydro-2H-thieno[3,4-b][1,4]dioxepin-8-yl)-9H-carbazole (M1) and 4,7-bis(thiophen-2-yl)benzo[c][1,2,5]thiadiazole (M2) was prepared via electrochemical technique. The copolymerization was performed with one to one monomer feed ratio. Electrochemical and optical properties of the resulting copolymer film (P3) and the homopolymer films of M1 and M2 (P1 and P2) were investigated by using cyclic voltammetry and UV-Vis spectrometry techniques, and the corresponding results were compared. Incorporation of M1 and M2 into copolymer matrix was clearly observed on the resulting cyclic voltammograms and UV-Vis spectra. P3 covered the visible regions coming from both P1 and P2, and exhibited a neutral state darker color than those of homopolymers. P3 film was found to have a multichromic behavior, appearing as brown in its neutral state while changing its color upon oxidation to dark-gray (at about 0.3 V), to blue (at about 0.6 V) and finally to grayish cyan (beyond 0.9 V), with a corresponding optical band gap of 1.65 eV.Item Numerical Solution of MHD Incompressible Convection Flow in Channels(2019) Gurbuz, Merve; Tezer-Sezgin, MunevverThe purpose of this paper is to study numerically the influence of the magnetic field, buoyancy force and viscous dissipation on the convective flow and temperature of the fluid in a square cavity, lid-driven cavity, and lid-driven cavity with an obstacle at the center. The continuity, momentum and energy equations are coupled including buoyancy and magnetic forces, and energy equation contains Joule heating and viscous dissipation. The equations are solved in terms of stream function, vorticity and temperature by using polynomial radial basis function (RBF) approximation for the inhomogeneity and particular solution. The numerical solutions are obtained for several values of Grashof number (Gr), Hartmann number (M) for fixed Prandtl number Pr = 0:71 and fixed Reynolds number Re = 100 with or without viscous dissipation. It is observed that in the absence of obstacle, viscous dissipation changes the symmetry of the isotherms, and the dominance of buoyancy force increases with an increase in Gr, whereas decreases when the intensity of magnetic field increases. The obstacle in the lid-driven cavity causes a secondary flow on its left part. The effect of moving lid is weakened on the flow and isotherms especially for large Gr when the cavity contains obstacle.Item Carpal Tunnel Syndrome: Evaluation of the Effects of Low-Level Laser Therapy With Ultrasound Strain Imaging(2019) Tezcan, Sehnaz; Ozturk, Funda Ulu; Uslu, Nihal; Nalbant, Merve; Yemisci, Oya Umit; 0000-0001-7204-3008; 29892976; ABC-5258-2020Objectives To evaluate the efficacy of low-level laser therapy on median nerve stiffness by using strain elastography in carpal tunnel syndrome (CTS). Methods This study included 37 wrists of 34 patients with mild or moderate CTS between January 2016 and August 2016. The control group comprised 17 patients (18 wrists) with CTS who were treated with wrist splinting for 3 weeks. The low-level laser therapy group included 17 patients (19 wrists) with CTS who were treated with a combination of splinting and low-level laser therapy, which was applied 5 times per week for 3 weeks. Clinical assessment scales, including the Symptom Severity Scale (SSS) and Functional Status Score (FSS), were obtained from our database. The cross-sectional area by ultrasound and strain ratio by elastography were studied. The differences in the strain ratio, cross-sectional area, SSS, and FSS between pretreatment and posttreatment periods in the groups were compared by the paired-sample t test. The correlations between changes in the strain ratio and the cross-sectional area, SSS, and FSS were analyzed by Pearson correlation coefficients. Results The control group included 13 women and 4 men, and the therapy group included 14 women and 3 men. In the therapy group, the mean values of the strain ratio, cross-sectional area, SSS, and FSS decreased significantly after laser therapy (P < .001) in contrast to the control group. No significant correlation was observed between the decreasing degree of the strain ratio and the cross-sectional area, SSS, and FSS after laser therapy. Conclusions The strain ratio and cross-sectional area of the median nerve decrease after low-level laser therapy. These changes may be related to the therapeutic effects of low-level laser therapy, such as nerve regeneration and improvement of the vascular supply.