Wos İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/11727/4807

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Author: search.filters.author.Sezgin, YaseminSubject: search.filters.subject.rats

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    Comparison of Two Morphometric Linear Methods to Measure the Alveolar Bone Loss Induced by Experimental Periodontal Disease in Rats
    (2020) Cetin, Mehtap Bilgin; Sezgin, Yasemin
    Objective: The aim of this study was to compare the direct and indirect linear morphometric measurements for the evaluation of alveolar bone loss after experimentally induced periodontitis in rats. Materials and Methods: Right mandibles of 30 Sprague Dawley rats were collected from a previous study which induced periodontitis using ligature model. In direct measurement group, the distance between cementoenamel junction and alveolar bone crest was evaluated by digital caliper and periodontal probe with a dental loop, whereas indirect group measurement was performed by an image analysis program on digital photographs. Results: The difference between groups was determined using Mann-Whitney U test. Average alveolar bone loss was 1.08 +/- 0.22 mm in direct measurement group and 1.19 +/- 0.33 mm inindirect measurement group. The variation between direct and in direct groups was not statistically significant (p>0.05). Conclusion: Based on the present result, it can be concluded that, direct morphometric analysis might be an essential alternative to indirect morphometric evaluations to measure alveolar bone loss after experimentally induced periodontitis in rats.
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    Evaluating the Effects of a Topical Preparation with Dexpanthenol, Silbiol, Undecylenic Acid, and Lidocaine on Palatal Mucosa Wound Healing in a Rat Model
    (2019) Sezgin, Yasemin; Cetin, Mehtap Bilgin; Bulut, Sule; Alptekin, Nilgun Ozlem; Borcek, Pelin; 0000-0003-4104-6462; 30322831; G-1816-2014; AAC-5448-2020; AAC-5931-2020
    Background: Postoperative complications occur after periodontal plastic surgeries, but an ideal treatment to overcome them has not been found yet. Aims: To evaluate the effects of topically applied Oral-norm gel on the healing of excisional wounds. Study Design: Animal experiment. Methods: Excisional wounds with a diameter of 3 mm were made in the center of the palatal mucosa of 63 Sprague Dawley rats. Seven animals were sacrificed at time 0. The remaining rats were divided into two groups: a test group in which the topical Oral-norm gel was applied three times a day and a control group in which nothing was applied. Seven animals in each group were sacrificed at 3, 7, 14, and 21 days. Mean wound surface area was measured photographically, while wound healing and width were evaluated microscopically. Results: The mean wound surface area decreased significantly after 3 days in both groups (p<0.001). Between days 3 and 7, the mean wound surface area decreased from 6.62 (2.85) to 0.83 (1.62) mm 2 in the control group and 5.07 (0.88) to 1.42 (1.67) mm 2 in the test group. The wound width decreased significantly on day 7 in both groups (p<0.001), with no further changes by day 14. Both groups had a significant increase in inflammation and vascularization on day 3 (p<0.001), with a reduction thereafter. No significant differences in macroscopic and microscopic measurements were observed between the groups at any time point (p>0.05). Conclusion: The Oral-norm gel has no positive healing effects in the palatal mucosa of rats.
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    COMPARISON OF TWO MORPHOMETRIC LINEAR METHODS FOR ALVEOLAR BONE LOSS MEASUREMENT IN EXPERIMENTAL PERIODONTITIS
    (2019) Cetin, Mehtap Bilgin; Sezgin, Yasemin
    Aim: The aim of this study was to compare direct (performed by a dental loop, periodontal probe and digital caliper over the alveolar bone) and indirect (performed by means of a special software program on digital photographs) linear morphometric measurements to assess the alveolar bone loss. Material and methods: Thirty right mandible of Sprague Dawley rats were obtained from a previous study that induced periodontitis with ligature model. In direct measurement group, the distance between cemento -enamel junction and alveolar bone crest was evaluated by digital caliper and periodontal probe using a dental loop, whereas in indirect group by an image analysis program on digital photographs. The difference between the groups was determined by Mann-Whitney U test. Results and discussions: Mean alveolar bone loss was 1.08 +/- 0.22 mm in direct measurement group and 1.19 +/- 0.33 mm in indirect measurement group. The difference between direct and indirect groups was not statistically significant (p>0.05). Conclusions: Based on the present result, it can be concluded that, the use of direct morphometric analysis may be an alternative to indirect morphometric evaluations for measuring alveolar bone loss in rats after the induction of experimental periodontitis.