TR-Dizin İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/11727/4808
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Item Pancreatic Tumors in Children(2021) Gezer, Hasan Ozkan; Temiz, Abdulkerim; Ezer, Semire; Yazici, Nalan; Demir, Senay; Hasbay, Bermal; Oguzkurt, Pelin; 0000-0002-4635-2613; 0000-0002-4209-9075; 0000-0001-6702-7265; A-4719-2018; AAJ-9529-2021; AAM-5138-2021; AAK-9310-2021Objective: Pancreatic rumors in children are exceedingly rare and hence present diagnostic and therapeutic challenges to pediatric surgeons. In this study, we aimed to present our experiences and treatment outcomes related to these rare tumors. Methods: The clinical data, laboratory investigations, radiological imaging, and the pathology and surgical details of patients with pancreatic tumors who were diagnosed between 2005 and 2019 were retrospectively reviewed. Results: A total of 9 patients (5 men) were included in the study. The most common symptom at the time of presentation was vague abdominal pain. A pancreatic rumor was detected incidentally in 4 patients. All tumors were non-functional primary rumors. Histopathological diagnosis of these tumors were solid-pseudopapillary tumors (n=3), congenital pancreatic cysts (n=3), pancreatoblastoma (n=1), rhabdomyosarcoma (n=1), and an undifferentiated carcinoma (n=1). In addition, 8 patients were treated surgically (through tumor excision, central pancreatectomy + distal pancreaticojejunostomy, distal pancreatectomy, and cystogastrostomy). Two deaths from tumor dissemination were recorded. The patients were followed-up at a mean duration of 72 months (range: 6-120 months). Conclusion: Pediatric pancreatic tumors arc rare and are usually benign in nature. They present symptoms that are often nonspecific. In non-metastatic cases, surgical tumor removal is the preferred method for the treatment. For most tumors, surgical resection is the optimal treatment that may be successfully performed with low morbidity rate when the lesion is either in the body or in the tail of the pancreas. The long-term outcomes with this approach are generally good.Item Tuberous sclerosis complex; a single center experience(2015) Erol, Ilknur; Savas, Tulin; Sekerci, Sevda; Yazici, Nalan; Erbay, Ayse; Demir, Senay; Saygi, Semra; Alkan, Ozlem; 26078697Aim: This study was planned with the aim of retrospectively reviewing the clinical and laboratory findings and therapies of our patients diagnosed with tuberous sclerosis and redefining the patients according to the diagnostic criteria revised by the 2012 International Tuberous Sclerosis Complex Consensus Group and comparing them with the literature. Material and Methods: 20 patients diagnosed with tuberous sclerosis complex in the Pediatric Neurology Clinic were examined retrospectively in terms of clinical findings and therapies. The diagnoses were compared again according to 1998 and 2012 criteria. Results: It was observed that the complaint at presentation was seizure in 17 of 20 patients and hypopigmented spots on the skin in 3 of 20 patients. On the initial physical examination, imaging findings related with the disease were found in the skin in 17 of the patients, in the eye in 5, in the kidneys in 7 and in the brain in 17. No cardiac involvement was observed in the patients. Infantile spasm was observed in 7 of the patients who presented because of seizure (n=17), partial seizure was observed in 7 and multiple seizure types were observed in 3. It was found that sirolimus treatment was given to 9 of 20 patients because of different reasons, 7 of these 9 patients had epileptic seizures and sirolimus treatment had no effect on epileptic seizures. According to 2012 diagnostic criteria, no marked change occured in the diagnoses of our patients. Conclusions: It was observed that the signs and symptoms of our patients were compatible with the literature. Molecular genetic examination was planned for the patients who were being followed up because of possible tuberous sclerosis complex. It was observed that sirolimus treatment had no marked effect on the seizure frequency of our patients.Item Variations in apparent diffusion coefficient values following chemotherapy in pediatric neuroblastoma(2015) Demir, Senay; Altinkaya, Naime; Kocer, Nazim Emrah; Erbay, Ayse; Oguzkurt, Pelin; 25519453PURPOSE In children the assessment of solid tumors' response to chemotherapy is based primarily on size reduction, which can be unreliable and a late marker, in the presence of necrosis. We aimed to establish whether apparent diffusion coefficient (ADC) values of childhood neuroblastomas show proportional changes in relation to chemotherapy response. METHODS We evaluated 15 pediatric patients with abdominopelvic neuroblastomas, who had undergone MRI before and after chemotherapy. Two radiologists retrospectively analyzed all images by drawing a round uniform region-of-interest in the solid/contrast-enhancing portion of the lesions in consensus. The ADC values from pre- and postchemotherapy images were compared. RESULTS Postchemotherapy ADC values were significantly higher than those obtained before treatment (P < 0.05, for minimum, maximum, and median ADC values). CONCLUSION Our results support diffusion-weighted MRI as a promising noninvasive biomarker of therapeutic responses. To the best of our knowledge, this is the first report to compare diffusion-weighted imaging findings before and after chemotherapy in childhood neuroblastic tumors.Item Mucormycosis with Orbital Apex Syndrome in a Renal Transplant Recipient(2015) Haberal, Mehmet; Kursun, Ebru; Turunc, Tuba; Demiroglu, Yusuf Ziya; Yabanoglu, Hakan; Demir, Senay; Caliskan, Kenan; Moray, Gokhan; Arslan, HandeMucormycosis is a rarely encountered invasive fungal infection with high mortality. Solid organ transplantation is one of the risk factors for mucormycosis. Mucormycosis can be classified in six different groups according to the anatomical localization; rhinocerebral, pulmonary, cutaneous, gastrointestinal, disseminated, and other less common involvements. This paper presented a mucormycosis case with rhinoorbitocerebral involvementin a renal transplantation receiver, which manifested with orbital apex syndrome.Item Evaluation of the Ophtalmic Artery Flow Pattern with Color-Doppler Ultrasonography in the Patients with Carotid Artery Stenosis(2015) Demir, Senay; Akgul, Erol; Aikimbaev, Kairgeldy; Tokmak, Naime; Inal, Mehmet; Aksungur, ErolPurpose: To assess whether ophtalmic artery flow patterns reflect the status of cerebral circulation in patients with carotid artery stenosis. Material and Method: Twenty-four patients including 14 men and 10 women, with varying degrees of monolateral or bilateral carotid artery stenosis were included in the study. Patients' ages ranged between 32 and 79 years (mean 60). The control group was composed of 12 subjects without carotid artery stenosis who had undergone digital substaction angiography for different purposes. Digital substraction angiography and color-Doppler ultrasonography were performed in all the patients and the control group. Degrees of carotid artery stenosis and flow patterns and velocities, pulsatility and resistance indices of ophtalmic arteries of two groups were compared. Results: Significant differences in ophtalmic artery flow patterns and velocities, pulsatility and resistance indices between those patients with carotid artery stenosis of more than 70% and the control group were recorded. Conclusion: Imaging of the ophtalmic artery with color-Doppler ultrasonography is a useful and cost-effective method that reflects the status of cerebral circulation in patients with carotid artery stenosis.Item A Rare Complication Developing After Hematopoietic Stem Cell Transplantation: Wernicke's Encephalopathy(2015) Solmaz, Soner; Gereklioglu, Cigdem; Tan, Meliha; Demir, Senay; Yeral, Mahmut; Korur, Asli; Boga, Can; Ozdogu, Hakan; 25912759Thiamine is a water-soluble vitamin. Thiamine deficiency can present as a central nervous system disorder known as Wernicke's encephalopathy, which classically manifests as confusion, ataxia, and ophthalmoplegia. Wernicke's encephalopathy has rarely been reported following hematopoietic stem cell transplantation. Herein, we report Wernicke's encephalopathy in a patient with acute myeloid leukemia who had been receiving prolonged total parenteral nutrition after haploidentical allogeneic hematopoietic stem cell transplantation. To the best of our knowledge, this is the first case reported from Turkey in the literature.Item Evaluation of brain perfusion in Alzheimer disease with perfusion computed tomography and comparison to elderly patient without dementia(2016) Yildirim, Tulin; Karakurum Göksel, Basak; Demir, Senay; Tokmak, Naime; Tan, Meliha; 27513264Background/aim: The aim of this study was to evaluate perfusion computed tomography (PCT) findings in patients with Alzheimer disease and to compare them with those of patients without dementia. Materials and methods: PCT was performed in 35 patients: 20 with Alzheimer disease (mean age, 69.7 +/- 5.5 years) and 15 control subjects (mean age, 67.5 +/- 3.5 years). Control subjects were elderly individuals with no cognitive problems who were admitted with headaches. All PCT examinations were performed on a 4-slice CT unit. The PCT analysis software program was used to calculate regional cerebral blood flow (rCBF), regional cerebral blood volume (rCBV), regional time-to-peak (rTTP) values in the bilateral frontal, temporal, and occipital cortices, and bilateral lentiform nucleus. Results: rCBF values in the bilateral frontal and temporal cortices and bilateral lentiform nucleus were significantly lower in the patients with Alzheimer disease than in the control subjects. There were no significant differences in rCBV values between Alzheimer disease and the control group. rTTP values in all cortical areas and bilateral lentiform nucleus were significantly higher in the patients with Alzheimer disease than in the control subjects. Conclusion: PCT is a rapid and reliable imaging modality for evaluating brain perfusion in Alzheimer disease.Item Anatomical assessment of chest radiographs(2018) Ozsahin, Esin; Boyan, Neslihan; Kizilkanat, Emine; Demir, Senay; Pelin, Can; Soames, Roger W.; Oguz, OzkanPurpose: The aim of this study was to determine the frequency of anatomical parameters and their measurement as seen on normal posteroanterior (PA) chest radiographs in a Turkish population. Materials and Methods: We evaluated fifty normal PA chest radiographs of Turkish population adults. The frequency of anatomical parameters and their measurement with respect to the diaphragm was evaluated. Results: The frequency of anatomical parameters and their measurement with respect to the diaphragm is as follows: level (right side higher in 98%, left and right sides same level 2%), lobulation (88% absent, 12% present), eventration (98% absent, 2% present) and contour (90% smooth, 10% not smooth); level of hilum (right and left sides same level 52%, left side higher 36%, right side higher 12%); number of pairs of ribs (twelve 96%, unable to determine 4%); number of ribs superposing the lung parenchyma (seven 2%, eight 4%, nine 24%, ten 70%); distance from the lateral margin of the vertebral body to the aorta (16.44 +/- 4.35 mm); angle between the vertebral body and the aorticopulmonary line (16.04 +/- 3.110); the carina angle (58.46 +/- 11.130) and the cardiothoracic ratio (38.75 +/- 4.27). Conclusion: The data presented in this study may be useful in understanding normal thoracic structures. A knowledge of the normal anatomy as well as variations are significant for physicians in the assessment of chest radiographs.