Browsing by Author "Magdiev Shukhrat Alisherovich"

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ARTICLE Course of the Wound Process With the Use of Modern Technologies in Local Treatment of Patients With Burns
(Başkent Üniversitesi, 2023) Fayazov Abdulaziz Jalilovich; Ruzimuratov Dilmurod Abdimuratovich; Kamilov Utkur Raimovich; Magdiev Shukhrat Alisherovich
ABSTRACT OBJECTIVES: We aimed to assess the wound-healing process using modern temporary wound dressings in local treatment of patients with burns. MATERIALS AND METHODS: From 2014 to the first half of 2022, the Department of Combustiology of the Republican Research Center of Emergency Medicine, Republic of Uzbekistan, conducted local treatment of 225 patients with superficial burns and 105 patients with deep IIIB/IV degree burns (age range, 1-60 years; mean age 17.5 ± 16.4 years). Most were children and adolescents (n = 146, aged 1-18 years); 79 were people of working age (age range, 19-60 years). The control group (115 patients with superficial burns, 55 patients with deep burns) received traditional local treatment using water-soluble ointments. The study group (110 patients with superficial burns, 50 patients with deep burns) received temporary wound dressings produced by New Dressing Materials CJSC, Russia (Parapran and Voskopran), with various options for local treatment. RESULTS: In 105 patients with deep burns, 122 necrectomy (early-delayed and delayed), 18 osteonecrectomy, and 134 autodermoplasty surgeries were performed. Fifty-two patients with traditional treatment received chemical necrectomy using 20% to 40% salicylic ointment. Less cases of toxic hepatitis, along with improving local reparative properties, were shown in patients who had active surgical tactics in the early stages after injury and temporary wound dressing than in the control group. Local treatment with temporary wound dressing in patients with extensive burns contributed to reduced purulent-septic complications, with no patients having burn sepsis. However, in severely burned patients in the control group, 3 patients (1.8%) had burn sepsis. CONCLUSIONS: Traditional methods of treatment are not acceptable for providing high-quality and qualified care for deep burns. Temporary wound dressings can reduce recovery time, being the most physiologically acceptable covering of burn surface wounds and achieving its main goal of early formation of granulation tissue, reducing secondary inflammatory processes.
Current Approaches to Intensive Care of Acute Toxemia in Severely Burned Adults
(Başkent Üniversitesi, 2022-06) Fayazov Abdulaziz Jalilovich; Mukhitdinova Hura Nuritdinovna; Kamilov Utkur Raimovich; Magdiev Shukhrat Alisherovich
ABSTRACT OBJECTIVES: Numerous studies have shown that the pathogenesis of burn toxemia based on the resorption of tissue necrosis products from burned tissue into the blood and lymph. Debridement of necrotic tissue of the burned area is reported to result in a decrease of body temperature in 1 to 2 days. The aim of the study was to evaluate features of the toxemia period in the intensive care unit patients to find out effectiveness of the comprehensive intensive therapy in first days of burn injury. MATERIALS AND METHODS: The intensive care unit data of 8 patients with severe thermal burns were analyzed retrospectively, including the vital signs, duration of the intensive care unit, daily fluid volume, blood glucose levels, utilized medication, and nutritional support. Statistical analysis was performed using Microsoft Excel and t test. RESULTS: The duration of stay in the intensive care unit was 13 ± 2.3 days with a total of 25.8 ± 8.9 days of hospitalization. The burned areas were 51.4 ± 19.7% in grade II-IIIA patients, 11.8 ± 8.9% in grade IIIB patients, and by Frank index of 92.5 ± 20.8. There was a correlation between the fluid therapy and systolic blood pressure. The volume of infusion therapy, albumin, parenteral nutritional supplementation, and blood glucose levels were correlated with decreased toxemia symptoms. Administration of antibiotics and heparin was not associated with the toxemia. Dopamine administration was maximal on the day 2 and was associated with patients’ hemodynamic situation. CONCLUSIONS: The inflammation was decreased with the parenteral glucose and nutritional supplements and anesthetics. The reverse correlation between the antibiotic therapy and toxemia indicated the correction of hemodynamic failure leading to a decrease of toxemia. The physical data and patients’ complaints were not objective indicators of intensive care effectiveness.