Browsing by Author "Hayes, Don"

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    Fungal Infection in Heart-Lung Transplant Recipients Receiving Single-agent Prophylaxis with Itraconazole
    (Başkent Üniversitesi, 2011-12) Hayes, Don; Flynn, Jeremy D.; Martin, Craig A.; Mansour, Heidi M.; Ball, Amanda M.
    Objectives: Heart and lung transplant recipients are at risk for invasive fungal infections. This study evaluated the affect of single-agent antifungal prophylaxis with itraconazole on the rate of fungal infections after heart or lung transplant. Materials and Methods: An observational, retrospective study was performed to evaluate the rate of fungal infections in heart and lung transplant recipients at the University of Kentucky Medical Center over 4.5 years who received itraconazole as a single therapy prophylaxis. Results: Eighty-three recipients (42 heart, 41 lung) had an overall fungal infection incidence of 16.9% (14/83), while the incidence was 11.9% for heart recipients (5/42), and 22.0% for lung recipients (9/41). Conclusions: Single-agent use with itraconazole in heart or lung transplant recipients did not affect the rate of fungal infection as compared with previous reports. The incidence of fungal infection increased significantly within 3 months after escalation of immunosuppressant for treatment of acute rejection.
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    Hemophagocytic Lymphohistiocytosis After Lung Transplant: Report of 2 Cases and a Literature Review
    (Başkent Üniversitesi, 2011-06) Diaz-Guzman, Enrique; Hayes, Don; Kesler, Melissa V.; Hobbs, Stephen B.; Dong, Bei
    Hemophagocytic lymphohistiocytosis is a rare and often fatal disease that may occur in solid organ transplant recipients. Here, we describe 2 patients who developed hemophagocytic lymphohistiocytosis after having a lung transplant and present a review of all cases of hemophagocytic lymphohistiocytosis occurring in solid organ transplant recipients. Diagnosis of hemophagocytic lymphohistiocytosis relies on the association of clinical findings and the presence of hemophagocytosis. Clinical presentation is nonspecific and patients may present with unexplained sepsis or multiple organ failure. Management consists of treating the underlying process; but unfortunately, the prognosis is poor.