Browsing by Author "Celik, H."

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Clinical characteristics of relapsed ovarian cancer patients with striking response to the bevacizumab at first relapse
(2019) Kose, Fatih; Alemdaroglu, S.; Mertsoylu, H.; Besen, A.; Guler, O.; Simsek, S.; Erbay, G.; Onal, C.; Celik, H.
Clinicopathologic characteristics of recurrent endometrioid endometrial cancer patients and analysis of methods used duriing surveillance
(2019) Simsek, S.Y.; Serbetcioglu, G.; Alemdaroglu, S.; Yetkinel, S.; Durdag, G.D.; Celik, H.; 31212025
Objective: To determine cilinicopathologic characteristics of recurrent endometrioid type endometrial cancer patients and analyze the methods applied in detection of recurrent disease during follow-up period. Methods: We have retrospectively reviewed the file records of the 226 patients who had endometrioid type carcinoma. Bimanual pelvic examination, speculum examination, carcinogenic antigen-125 (CA125) testing, vaginal cuff cytologic screening, transabdominal ultrasound (TAUS) and transvaginal ultrasound (TVUS) imagings were performed within the context of routine follow-up control examinations in the post-treatment period in every 3 months within the first 2 years and in every 6 months in the following 2 years and with annual control in the consecutive years. Results: Mean follow-up durations was 25.7 +/- 18.9 months while recurrence rate was 3.1%. The study patient group underwent totally 1116 times TVUS and 1084 times whole TA-US evaluations, 973 times vaginal cuff cytological screening, 1125 times pelvic and general physical examinations beside 1060 times CA-125 testings were performed in accordance with our routinely performed follow-up protocol. The asymptomatic recurrent cases; one of those was dignosed with pelvic examination while diagnosis was established using TA-USG evaluation in the other asymptomatic patient. The other 5 cases were symptomatic. Pelvic examination, Computed Tomograhy and Magnetic Resonance Imaging were utilized in diagnosing 1, 3 and 1 of those patients, respectively. Conclusion: The presence of symptoms and pelvic examination seem to be the most effective modalities in detecting recurrence in follow-up of endometrial cancer. It would be reasonable to optimize intervals between follow-up visits and to determine the appropriate evaluations by considering risk levels of the patients. (C) 2019 Elsevier Masson SAS. All rights reserved.
Effect of COVID-19 pandemic lockdowns on planned cancer surgery for 15 tumour types in 61 countries: an international, prospective, cohort study
(2021) Celik, H.; Akilli, H.; 0000-0002-5240-8441; 34624250; AAX-3230-2020
Background Surgery is the main modality of cure for solid cancers and was prioritised to continue during COVID-19 outbreaks. This study aimed to identify immediate areas for system strengthening by comparing the delivery of elective cancer surgery during the COVID-19 pandemic in periods of lockdown versus light restrictions. Methods This international, prospective, cohort study enrolled 20 006 adult (>= 18 years) patients from 466 hospitals in 61 countries with 15 cancer types, who had a decision for curative surgery during the COVID-19 pandemic and were followed up until the point of surgery or cessation of follow-up (Aug 31, 2020). Average national Oxford COVID-19 Stringency Index scores were calculated to define the government response to COVID-19 for each patient for the period they awaited surgery, and classified into light restrictions (index <20), moderate lockdowns (20-60), and full lockdowns (>60). The primary outcome was the non-operation rate (defined as the proportion of patients who did not undergo planned surgery). Cox proportional-hazards regression models were used to explore the associations between lockdowns and non-operation. Intervals from diagnosis to surgery were compared across COVID-19 government response index groups. This study was registered at ClinicalTrials.gov, NCT04384926. Findings Of eligible patients awaiting surgery, 2003 (10middot0%) of 20 006 did not receive surgery after a median follow-up of 23 weeks (IQR 16-30), all of whom had a COVID-19-related reason given for non-operation. Light restrictions were associated with a 0middot6% non-operation rate (26 of 4521), moderate lockdowns with a 5middot5% rate (201 of 3646; adjusted hazard ratio [HR] 0middot81, 95% CI 0middot77-0middot84; p<0middot0001), and full lockdowns with a 15middot0% rate (1775 of 11 827; HR 0middot51, 0middot50-0middot53; p<0middot0001). In sensitivity analyses, including adjustment for SARS-CoV-2 case notification rates, moderate lockdowns (HR 0middot84, 95% CI 0middot80-0middot88; p<0middot001), and full lockdowns (0middot57, 0middot54-0middot60; p<0middot001), remained independently associated with non-operation. Surgery beyond 12 weeks from diagnosis in patients without neoadjuvant therapy increased during lockdowns (374 [9middot1%] of 4521 in light restrictions, 317 [10middot4%] of 3646 in moderate lockdowns, 2001 [23middot8%] of 11 827 in full lockdowns), although there were no differences in resectability rates observed with longer delays. Interpretation Cancer surgery systems worldwide were fragile to lockdowns, with one in seven patients who were in regions with full lockdowns not undergoing planned surgery and experiencing longer preoperative delays. Although short-term oncological outcomes were not compromised in those selected for surgery, delays and non-operations might lead to long-term reductions in survival. During current and future periods of societal restriction, the resilience of elective surgery systems requires strengthening, which might include protected elective surgical pathways and longterm investment in surge capacity for acute care during public health emergencies to protect elective staff and services. Funding National Institute for Health Research Global Health Research Unit, Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, Medtronic, Sarcoma UK, The Urology Foundation, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research. Copyright (c) 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license.
Panoramic View of Endometrioid Endometrial Cancer in Turkey: A Retrospective, Multicenter Study of Turkish Society of Gynecologic Oncology (TRSGO-END002)
(2019) Celik, E.; Gulseren, V.; Kayan, B. Ozge; Oz, M.; Kocaman, E.; Akgol, S.; Alemdoroglu, S.; Topuz, S.; Gungorduk, K.; Demirkiran, F.; Meydanli, Meydanli, M. M. x; Akbayir, O.; Celik, H.; Ayhan, A.
Prognostic and Therapeutic Factors for Low-Grade Serous Ovarian Carcinoma: A Multicentric, Retrospective Study of The Turkish Society of Gynaecologic Oncology
(2019) Vatansever, D.; Taskiran, C.; Meydanli, M. M.; Gungorduk, K.; Akbayir, O.; Yalcin, I.; Demirkiran, F.; Sozen, H.; Ozgul, N.; Celik, H.; Onan, M. A.; Taskin, S.; Oge, T.; Simsek, T.; Abboud, S.; Ayhan, A.; AAL-1923-2021; AAJ-5802-2021
Role of Initial Surgery in Malignant Ovarian Germ Cell Tumors
(2017) Kocaman, E.; Coban, G.; Sahin, H.; Akilli, H.; Celik, H.; Kuscu, E.; Ayhan, A.; 0000-0002-3285-5519; 0000-0002-0992-6980; AAI-9974-2021; AAL-1923-2021; AAI-8792-2021; AAJ-5802-2021
Role of Initial Surgery in Malignant Ovarian Germ Cell Tumors
(2016) Kocaman, E.; Coban, G.; Sahin, H.; Akilli, H.; Celik, H.; Kuscu, E.; Ayhan, A.; 0000-0002-3285-5519; 0000-0002-0992-6980; AAI-9974-2021; AAJ-5802-2021; AAI-8792-2021; AAL-1923-2021
The Role of Preoperative Routine Computed Tomography Scanning in The Estimation of High-Risk Factors in Endometrial Cancers
(2018) Coban, G.; Erbay, G.; Kose, F.; Alemdaroglu, S.; Onal, C.; Celik, H.; https://orcid.org/0000-0002-3285-5519; https://orcid.org/0000-0002-1706-8680; https://orcid.org/0000-0002-0156-5973; https://orcid.org/0000-0003-4335-6659; https://orcid.org/0000-0002-2742-9021; AAI-9974-2021; AAK-5370-2021; G-4827-2016; AAI-8400-2021; HOC-5611-2023; AAL-1923-2021
Objective: To examine the role of preoperative computed tomography (CT) in estimation of the high-risk factors in endometrial cancer cases. Materials and Methods: The data from 161 cases who were diagnosed with endometrioid adenocarcinoma with endometrial biopsy, and staged surgically were retrospectively analyzed. The diagnostic performance of a whole abdominal CT scan in terms of tumor diameter, myometrial invasion, cervical, adnexal, omental involvement, as well as pelvic para-aortic nodal involvement was examined. In addition, extra-uterine and extra-nodal incidental signs were identified. Results: The accuracy rate of preoperative CT scanning was found to be 42%, 78%, 80%, 95%, 97%, 88%, 89%, and 88% for tumor diameter, myometrial invasion, cervical, adnexal, and omental involvement, as well as pelvic para-aortic nodal involvement, respectively. Extra-uterine and extra-nodal incidental signs were identified in 18% of the cases. Incidental findings entailed a modification of management only in one case (0.62%). Conclusion: Preoperative CT scan findings do not present an alternative to intraoperative frozen section analysis or surgical staging. However, based on the findings from the preoperative CT scan, accuracy of predictions about which patients require more complex procedures (lymphadenectomy) can be improved, and therefore preoperative CT scanning may prove useful in more effective use of operating rooms.
Validation of the ESMO-ESGO-ESTRO Consensus Conference Risk Grouping in Turkish Endometrial Cancer Patients Treated with Comprehensive Surgical Staging
(2019) Gultekin, M.; Guler, O. C.; Sari, S. Yuce; Yildirim, B. Akkus; Mustafayev, T. Z.; Atalar, B.; Bolukbasi, Y.; Onal, H. C.; Celik, H.; Yuce, K.; Ayhan, A.; Yildiz, F.; 0000-0001-6908-3412; AAC-5654-2020