PubMed İndeksli Açık & Kapalı Erişimli Yayınlar
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Item GnRH agonist triggering affects the kinetics of embryo development: a comparative study(2016) Gurbuz, Ali Sami; Gode, Funda; Uzman, Mehmet Sukru; Ince, Betul; Kaya, Melek; Ozcimen, Necati; Ozcimen, Emel Ebru; Acar, Ali; 27059823Background: To evaluate the effects of an ovulation triggering agent, human chorionic gonadotropin (hCG), versus a gonadotropin-releasing hormone agonist (GnRHa) on early embryo development in vitro using a time-lapse system. Methods: Retrospective analysis of a prospectively collected database. A total of 739 embryos from 152 infertile couples undergoing intracytoplasmic sperm injection cycles. Interventions : Embryo culture in a time-lapse incubator (EmbryoScope, Vitrolife, Goteborg, Sweden). Main Outcome Measures: Embryo morphokinetic parameters. Results: In the 152 women, 252 embryos were derived from GnRHa-triggered cycles compared with 487 embryos derived from hCG-triggered cycles. Time-lapse analysis revealed that embryos from cycles triggered by a GnRHa cleaved faster than embryos derived from hCG-triggered cycles. Conclusion: Triggering with a GnRHa in in vitro fertilization cycles affects embryo kinetics.