PubMed İndeksli Açık & Kapalı Erişimli Yayınlar
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Item Incidence of root canal treatment of second molars following adjacent impacted third molar extraction(2016) Oguz, Yener; Soydan, Sidika Sinem; Onay, Emel Olga; Cubuk, Secil; 30894952Background/purpose: The aim of this study was to evaluate the incidence of requirement for root canal treatment of adjacent second molars following the surgical extraction of an impacted third molar. Materials and methods: The dental records of 6323 consecutive patients who had impacted third molars removed surgically were evaluated and the incidence of postoperative root canal treatment requirement of adjacent second molars was determined. Patients who required root canal treatment of neighboring second molars were accepted as the study group, while the remaining patients were accepted as a control group. Sex, age at the time of the operation, localization of third molar, the depth of impaction, angulation of the tooth, and the professional experience of the surgeon performing the operation were evaluated from patient records. Results: The incidence of requirement of root canal treatment for second molars following a neighboring impacted third molar extraction was 0.17% (11/6323) and invariably occurred in the mandible. The mean age of the study group was found to be significantly higher than the control group (31 years vs. 23 years). The years of professional experience of the surgeons was significantly lower in the study group than in the control group. Conclusion: Although the incidence is minimal, iatrogenic subluxation injuries occurring during the surgical removal of impacted third molars can lead to pulpal complications and a requirement for root canal treatment of adjacent second molars. Copyright (C) 2015, Association for Dental Sciences of the Republic of China. Published by Elsevier Taiwan LLC.Item Odontogenic effects of two calcium silicate-based biomaterials in human dental pulp cells(2018) Onay, Emel Olga; Yurtcu, Erkan; Terzi, Yunus Kasim; Ungor, Mete; Oguz, Yener; Sahin, Feride İffet; 30070078Background. The goal of treating exposed pulp with an appropriate pulp capping material is to promote the dentinogenic potential of the pulpal cells. There have been recent attempts to develop more effective pulp-capping materials. Objectives. The aim of this study was to evaluate the effect of newly developed calcium silicate-based material on odontogenic differentiation of primary human dental pulp cells (HDPCs), in comparison with a contemporary calcium silicate-based material. Material and methods. Human dental pulp cells isolated from dental pulps were cultured in standard culture conditions in Dulbecco's Modified Eagle's Medium (DMEM) and then the effects of Micro-Mega mineral trioxide aggregate (MM-MTA) (Micro-Mega, Besancon, France) and ProRoot MTA (MTA) (Dentsply Sirona, Tulsa, USA) (positive control) were evaluated on HDPCs at 1, 7 and 14 days. Untreated cells were used as a negative control. Odontoblastic differentiation was assessed by alkaline phosphatase (ALP) activity. Runtrelated transcription factor 2 (RUNX2), alkaline phosphatase liver/bone/kidney (ALPL), bone morphogenetic protein 2 (BMP2), dentin sialophosphoprotein (DSPP), and Distal-less homeobox 3 (DLX3), as odontoblastic/ osteoblastic expression markers, were evaluated by semi-quantitative real-time polymerase chain reaction (RT-PCR) analysis. Calcium levels of culture media were also determined. Results. The MM-MTA group significantly increased the expression of BMP2 compared with that of the MTA group at 3 different time periods (p < 0.05). The up-regulation of ALPL between day 1 and 14 and the up-regulation of DSPP between day 7 and 14 were significant in both groups (p < 0.05). Micro-Mega MTA and MTA exhibited similar messenger RNA (mRNA) expression levels of ALPL, DSPP, RUNX2, DLX3, and ALP activities, as well as calcium levels. Conclusions. Based on the cell responses observed in this study, MM-MTA might be used efficiently in dental pulp therapy as a potential alternative to MTA.