TR-Dizin İndeksli Açık & Kapalı Erişimli Yayınlar
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Item Treatment Outcomes of Breast Cancer Liver Metastasis Treated with Stereotactic Body Radiotherapy(2018) Onal, Cem; Guler, Ozan Cem; Yildirim, Berna Akkus; https://orcid.org/0000-0002-2742-9021; https://orcid.org/0000-0001-6908-3412; https://orcid.org/0000-0001-6661-4185; 30296648; HOC-5611-2023; AAC-5654-2020; V-5717-2017Background: To assess the outcomes of breast cancer liver metastasis (BCLM) treated with stereotactic body radiotherapy (SBRT) and systemic treatment. Materials and methods: Patients with oligometastasis at the time of liver metastasis (LM) or who became oligometastatic (<= 5 metastases) after systemic treatment were assessed. Twenty-nine liver metastatic lesions were treated with a total of 54 Gy delivered in 3 fractions. The local control (LC), overall survival (OS), and progression-free survival (PFS) rates were calculated using Kaplan-Meier analyses. Results: A total of 22 patients with 29 liver metastatic lesions treated with liver SBRT between April 2013 and September 2017 were retrospectively analyzed. After a median follow-up time of 16.0 months (range 4.4-59.4 months), 18 patients (82%) had disease recurrence, median of 7.4 months (range 1.0-27.9 months) after completion of liver SBRT. The 1- and 2-year OS rates were 85% and 57%, and the 1- and 2-year PFS rates were 38% and 8%, respectively. The 1- and 2-year LC rates were 100% and 88%, respectively. No significant prognostic factors, including disease extension, size of metastasis, number of liver metastasis and timing of liver metastasis, hormonal status affecting OS, PFS and LC were found. No patients experienced Grade 4 or 5 toxicity; furthermore, only one patient experienced rib fracture 6 months after completion of treatment, and one patient had a duodenal ulcer. Conclusion: This study is the first to evaluate the feasibility of SBRT to BCLM patients. Liver SBRT is a conservative approach with excellent LC and limited toxicities. (C) 2018 Elsevier Ltd. All rights reserved.Item Analysis of the relationship between tuberculosis-related mortality and nitrous oxide emission levels in the world with the environmental Kuznets curve method(2022) Torun, Serife; Yilmaz, Kadir; Ozkaya, Sevket; Yosunkaya, Sebnem; Akcay, Sule; 36326361Background/aim: It was aimed to analyze the relationship between tuberculosis-related mortality and nitrous oxide emission levels in the world with the Environmental Kuznets Curve (EKC) Method. Materials and methods: WHO ICD-10 mortality list data and the World Bank Country Data (WBCD) were used between 1997 and 2017 for 12 countries. Cubic regression analysis was used for EKC Analysis. Results: The difference between male and female deaths between 1996 and 1998 has increased sharply since 1999. Male deaths consistently occurred significantly more than female deaths. There was a significant and negative correlation between Nitrous oxide emissions (% change from 1990) and tuberculosis-related deaths, whereas there were significant and positive correlations between Nitrous oxide emissions in the energy sector (% of total) and tuberculosis-related deaths (p < 0.01). EKC analysis results showed that there is a U shaped between tuberculosis-related mortality and nitrous oxide emission levels in the world. Conclusion: Research results show that the relationship between nitrous oxide change and mortality is negative in the short term and positive in the long term. Therefore, although nitrous oxide gases cause respiratory diseases and mortality, it may be possible to transform a harmful environmental factor into a positive by developing devices or methods that will convert these gases into free radicals.Item Investigation of cochlear microphonics recorded with different stimulus types(2022) Guneser, Ozgecan; Yigit, Ayse Arzu; Alniacik, Asuman; Yanarates, Kursat; Cakmak, Eda; 0000-0001-5837-6877; 36326414; C-2636-2017Background/aim: Electrocochleography (ECochG), one of the first defined tests under auditory evoked potentials, is a total electrical response of inner and outer hair cells inside the cochlea and auditory nerve record technique to the presence of an acoustic stimulus. These records can be used in Meniere disease and auditory neuropathy spectrum disorder diagnosis, intraoperative monitoring. In addition, the presence of cochlear microphonics plays a crucial role in auditory neuropathy spectrum disorder diagnosis. In our study, healthy individuals were tested with extratimpanic electrocochleography record method via Click and LS CE-Chirp stimulus, and the results were compared to the age, sex, and noise sensitivity categories. Materials and methods: This study had executed at Baskent University, Faculty of Health Sciences Audiology laboratory. The study group consisted of 42 volunteers between 18 and 40 years old. To understand the suitability of volunteers, pure tone audiometry, tympanometry, and transient otoacoustic emission tests were performed. Individuals with no hearing loss were tested with 100 dBnHL intensity level via click and LS CE-Chirp stimulus. The obtained values were statistically evaluated in the SPSS 23.0 program in accordance with the data distribution. An independent sample t-test was used for data showing normal distribution, and Mann-Whitney U test was used for data not showing normal distribution. The level (p < 0.05) was considered statistically significant for all analyses performed. Results: Cochlear microphonic amplitudes recorded with click and LS CE-Chirp stimuli were higher in males than in females (p = 0.051 and p = 0.001, respectively). When the age groups were evaluated, no difference was observed in the CM amplitudes obtained with both click and LS CE-Chirp stimuli. There was no correlation between age and CM amplitudes. Additionally, it was determined that the CM amplitudes recorded with the click stimulus in individuals with noise sensitivity were higher than those without noise sensitivity (p = 0.051). Conclusion: It is thought that the ECochG amplitudes of different gender, different age, and different noise sensitivity, which are the results of our study, can be used in the diagnosis of diseases such as auditory neuropathy spectrum disorder.Item An Approach to Pediatric or Mentally Deficient Donors from a Bioethical Perspective: Considerations and Recommendations on Behalf of the Donor Research Team of the Turkish Society of Hematology (DART)(2022) Keles, Sukru; Boga, Can; Tekkesin, Funda; Ozen, Ilknur Nizam; Kozanoglu, Ilknur; 35699265; GXH-4007-2022Item The Mediating Role of Organisational Cynicism on the Relationship Between Technostress and Job Performance: A Research on Teachers(2022) Yalcin, Rukiye Can; Gokmen, Yunus; Erdem, Haluk; Turen, UfukThis study's primary purpose is to examine organisational cynicism's mediating role in the relationship between technostress and job performance. Data are obtained from 234 teachers working in public and private schools in Turkey. In the study, correlation and regression analyses have been performed to determine the relationships and effects between variables, and the structural equation model has been used to verify the scales of the variables. In addition, the mediation role in the study has been examined with the bootstrap test in the Process module. Findings show that the validity and reliability of the scales are ensured by the results of commonly used validity and reliability analysis methods. Additionally, technostress and organisational cynicism decrease job performance and technostress significantly increase organisational cynicism. Further mediation analysis reveals that organisational cynicism partially mediates the relationship between technostress and job performance.Item Applicability of the Vienna Sale Agreement (CISG) for Advanced Purchase Agreements of COVID-19 Vaccines in EU Member States(2022) Cortoglu Koca, SemaThe European Commission has signed advanced purchase agreements with various vaccine manufacturers for the production, purchase and supply of the COVID-19 vaccine in the EU. Some parts of the agreement texts with AstraZeneca, CurevacAg and Pfizer Inc./BioNTech have been blacked out. In these agreements, it is understood that Belgian courts are competent and Belgian law is chosen. In a dispute, it is possible for the competent courts to apply CISG since Belgium is a party to the CISG. Even if choice of law hasn't been made, the fact that the workplaces of all parties to these ageements are party to CISG, makes the CISG applicable. This study evaluates the applicability of the CISG to advanced purchase agreements (especially made with AstraZeneca) in EU Member States.Item Pathology, Classification, Clinical Manifestations and Prognosis of Langerhan's Cell Histiocytosis: A Single Center Experience(2022) Hasbay, Bermal; Kocer, Nazim Emrah; Kayaselcuk, Fazilet; Canpolat, Emine Tuba; Buyukkurt, Nurhilal; Erbay, AyseObjective: The aim of the study is to raise awareness about clinical features, histopathological and radiological analyzes and treatment details of this rare disease. Methods: A total of 55 Langerhans cell histiocytosis patients, diagnosed between the year 2006 and October 2020 in our department were included in the study. The patients were evaluated in terms of age, gender, tumor localization, risk groups, treatment modalities, recurrence, and outcome of the disease. Results: Twenty-three out of 55 patients were children and 32 were adults. The ages of the patients were between 7 months and 72 years. Thirty-seven of the cases were male and 18 were female. The most common clinical complaint in both groups was pain and swelling. The duration between the onset of the patient complaints and admission to the hospital varies between 7 days-12 months in children, and 10 days-23 years in adults. Forty-three of the cases had single organ involvement and 12 had multiorgan involvement. The most frequently affected organ in both groups was bone. Forty of the 55 patients had follow-up data and the treatment modalities are as follows: Nine patients radiotherapy, 8 patients chemotherapy+steroid, 7 patients chemotherapy, 2 patients chemotherapy+radiotherapy+steroid, 1 patient steroid, 2 patients chemotherapy+radiotherapy. Eleven patients were followed up without additional treatment after surgery. Median follow-up from the time of biopsy was 45.9 months in children and 41.9 months in adults. Conclusions: As a result, diagnosis requires a high degree of suspicion and final diagnosis is based on the histological examination of the lesions and biopsies.Item An Examination of Medicine and Folk Medicine Elements on the Example of a Medical Text in Verse(2022) Aytac, Uyesi AsliPeople have sought cures for the diseases and ailments they have experienced since ancient times. These were sometimes the sorcerers, herbalists, embers, enchanters, atasaguns or shamans of the period, and sometimes the physicians who worked on modern medicine of the period. Anatolia, as the land where civilizations intersect, contains traces of many cultures and has a very deep structure in terms of cultural accumulation. Considering ancient medicine in Anatolia, it can be seen that sometimes modern medical knowledge and traditional folk medicine methods are used together. These methods are frequently mentioned in written texts and many works in the field of health, both in copyright and translation, have been created. The fact that they include easy treatment methods for illnesses and that they contain medical information that the public can use in daily life emphasize the importance of such texts. It is known that the oldest medical texts in Turkish written in Anatolia were created in the 14th century. Since then, many works including field information such as medicine, folk medicine, pharmacology, botany have a special importance in terms of fully revealing the vocabulary and structure of our language. The text, which is our subject of study, is registered in the collection of Ankara National Library Elazig Provincial Public Library with the number 23 Hk 2/3. The title of the work appears to be Manzume-i Tib and its author Ferdi. The text, written in "me fa' i lun me fa' i lun fe' u lun" prosody pattern and consists of 61 couplets. Although the name of the author appears as Ferdi in the manuscript, the note that the author is not known was written at the beginning of the work. Although the year of writing is not known, the text was written in Old Anatolian Turkish. The note to the head of the manuscript contains the information that it contains some information about health protection. In its content, factors affecting health and disease are emphasized. The medical knowledge until the time of writing and some practices from the field of folk medicine have been combined to include behaviors that should be done in the treatment of diseases and avoided for some diseases. Writing a text on the subject of medicine with prosody, besides the purpose of informing, it also ensures the permanence of the information transferred in a certain harmony. In the text, on the subject of diseases; Problems such as indigestion, headache, sore throat or dry throat, weakness, paralysis, sciatica, meningitis, constipation, hemorrhoids, cramps and pain were included. Among the treatments; Methods such as vomiting, laxative, cupping, and consent have been discussed. Although in small numbers, there are herbal preparations that can be used for some ailments such as tooth jaundice and bad breath. In the face of some ailments and conditions, the daily foods recommended for therapeutic purposes have been pointed out. It is seen that information about mood is also included in addition to physical health. In our study, by giving the transcription of the aforementioned manuscript, it will be pointed out the diseases, diseases and the treatment methods recommended for them. These suggestions will be examined under the headings of beneficial and harmful actions. Comparisons will be made by giving examples from other medical texts written in Anatolia. At the end of the review, there will be a glossary of terms used in the fields of medicine and folk medicine. With further examination of such texts, Old Anatolian Turkish vocabulary will be put forward in a healthier way and data that shed light on various fields such as botany, folklore, pharmacology and psychology will be obtained along with medicine.Item The Relationship Between Dietary Intakes and Total Kidney Volume in Patients with Autosomal Dominant Polycystic Kidney Disease Dietary Intake and Polycystic Kidney Volume(2022) Sevim, Yonca; Cebeci, Egemen; Ozkan, Ozlem Persil; Savas, Yildiray; Ozturk, Savas; Kiziltan, GulAim: There is a need to understand autosomal dominant polycystic kidney disease (ADPKD) patients' dietary habits since dietary interventions may have potential effects on ADPKD. In this study, we aimed to analyze the relationship between dietary nutrient intake and total kidney volume (TKV).Methods: This cross-sectional study was conducted on 54 ADPKD patients recruited from the Nephrology outpatient clinic between June and July 2014. TKV was determined by magnetic-resonance imaging and general characteristics, biochemical and urinary parameters were determined. The nutrient intakes of patients were calculated using the three-day dietary records obtained on three consecutive days.Results: The total kidney-volume median was found to be 1407 mL. Patients' total dietary energy and protein intakes were 25.8 +/- 9.4 kcal/kg, 0.9 +/- 0.3 g/kg, respectively. The percentage of carbohydrates, protein, and fat in energy was 49 +/- 7%, 14 +/- 3%, 37 +/- 7%, respectively. The mean intakes of thiamin, riboflavin, B6, calcium, magnesium, and zinc were sufficient, the mean dietary potassium intake was insufficient; and sodium intake was excessive in both sexes. In females, there was a negative but weak correlation between dietary vitamin C intake and TKV. In males, a negative but weak correlation was found between TKV and dietary intake of fiber, water, vitamin B6, vitamin K, magnesium, and iron. Conclusions: Dietary micronutrient intake may affect TKV according to sex.Item Which has an Influence on Mean Platelet Volume: Allergic Rhinitis or Asthma?(2022) Senol, Handan Duman; Ozdogru, Emine Ece; Sancakli, Ozlem; Dogru, Mahmut; Tuncel, TubaAim: Bronchial asthma and allergic rhinitis are mediated by similar allergic inflammatory mechanisms. Platelets play a role in allergic reactions which are inflammatory processes. The mean platelet volume (MPV) is a marker of platelet activation. This study aimed to investigate MPV value differences between children with allergic rhinitis during symptomatic or asymptomatic periods to determine whether MPV is a useful indicator of inflammation in allergic rhinitis. Materials and Methods: The records of those patients with allergic rhinitis were analyzed retrospectively. Patients over two years of age who had complete blood count results from both their asymptomatic and the symptomatic periods were included in this study. Clinical characteristics (age, age at diagnosis, symptoms, and comorbid allergic diseases) and laboratory data (thrombocyte count, MPV, white blood cell count, eosinophil count, and percentage, immunoglobulin E level, and skin prick test results) were recorded from the patient files and the hospital registry system. Results: MPV values during the symptomatic periods were statistically significantly higher than those from the asymptomatic period (p<0.001) in all patients. When the patients were grouped according to having asthma or not, MPV was found to be higher in the symptomatic period compared to the asymptomatic period in the group with asthma, but there was no difference between these two periods in the group without asthma (p=0.017, p=0.102 respectively). Additionally, MPV levels were significantly higher in the asthma group during both the symptomatic and the asymptomatic periods (p=0.04, p=0.013, respectively). Conclusion: This study suggests that MPV cannot be used as an inflammation indicator in the symptomatic period for patients with allergic rhinitis. Asthma influences MPV values. It is recommended to conduct more detailed and prospective studies to show MPV inflammation in AR.