TR-Dizin İndeksli Açık & Kapalı Erişimli Yayınlar
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Item Risk Factors and Clinical Determinants in Bronchiolitis of Infancy(2020) Atay, Ozge; Pekcan, Sevgi; Gokturk, Bahar; Ozdemir, Mehmet; 32584231OBJECTIVES: The aims of this study was to demonstrate the viral pathogens, to evaluate the clinical prognosis, risk factors for recurrence, severity of acute viral bronchiolitis episodes among pediatric patients. MATERIALS AND METHODS: Our study included 101 children aged between 2 months and 2 years diagnosed with clinical bronchiolitis between September 2011 and April 2012. The demographics and clinical, laboratory, and radiological results of the patients were recorded. Nasopharyngeal swab samples were collected and analyzed through polymerase chain reaction (PCR) method. The patients were followed up for at least one year for new episodes, existence of wheezing, frequency of pulmonary infections, and progression of asthma. RESULTS: In half of the patients, determinants were indicated through the PCR method, with the most frequent being respiratory syncytial virus (44%). The frequency of bronchiolitis was higher in prematures (p<0.005). There was a relationship between crowded family structure and the existence of wheezing (p=0.003), increased recurrence (p=0.014), and need for inhaler treatment (p=0.014). The frequency was higher in patients living in urban cities (p<0.001), in houses with heating stoves (p=0.001), and in houses with smokers (p=0.001). Patients living in houses with heating stoves had more severe episodes (p=0.018). Recurrent wheezing and the need for regular inhaler usage were positively correlated with high API scores (p=0.008 and p=0.002, respectively). CONCLUSION: Prematurity, exposure to smoking, living in a crowded house with heating stoves, and an urban life are the risk factors for frequent bronchiolitis. The API can be used to predict the recurrence of bronchiolitis.Item Investigation of the Relationship between Asthma and Visceral Obesity by Epicardial Fat Thickness Measurement(2019) Yilmaz, Hatice Eylul Bozkurt; Yilmaz, Mustafa; Sen, Nazan; Unsal, Zuhal Ekici; Eyuboglu, Fusun Oner; Akcay, Sule; 0000-0003-3225-2686; 0000-0002-8360-6459; AAB-5175-2021; 30664419; AAR-4338-2020; AAD-5602-2021OBJECTIVES: Obesity is a risk factor defined in recent years for asthma. It is associated not only with asthma but also with many cardiovascular diseases. Visceral obesity is a more significant risk factor than general obesity in cardiovascular diseases. Although the association of visceral obesity with cardiovascular diseases is well known, the relationship in patients with asthma is not fully understood. The aim of the present study was to investigate whether there is a relationship between asthma and visceral fat by using epicardial fat thickness (EFT) measurement. MATERIALS AND METHODS: A total of 401 subjects (229 patients with persistent asthma and 172 controls) were enrolled in the study. In our study, EFT was measured, recorded by echocardiography, and was evaluated whether there was a statistical significant difference between the two groups. RESULTS: The mean EFT was 5.84 +/- 0.79 mm in the patient group and 5.71 +/- 0.93 mm in the control group. There was no statistically significant difference between the groups (p=0.145). Similarly, when we compared control and asthma severity subgroups, we did not find statistically significant differences (control group mean 5.71 +/- 0.93 mm, mild group mean 5.86 +/- 0.81 mm, moderate group mean 5.8 +/- 0.84 mm, and severe group mean 5.83 +/- 0.67 mm, p=0.505). CONCLUSION: In the present study, we observed that the EFT did not increase in patients with asthma compared with the normal population. Based on our results, we suggest that visceral obesity may not be a significant risk factor for asthma.Item Effect of Obesity on Pulmonary Function in Children with Mild Persistent Asthma(2016) Koksal, Burcu Tahire; Ozbek, Ozlem Yilmaz; 0000-0001-9580-7656; AAF-2109-2021Objective: The prevalence of asthma is increased in obese individuals. There is no concrete evidence that an increase in body mass index is associated with a loss of pulmonary function in childhood asthma. Our aim was to investigate the effect of obesity, atopy, and sex on pulmonary function in asthmatic children. Materials and Methods: This study is a cross-sectional analysis in children with mild persistent asthma. A total of 76 obese and 55 lean children with asthma were recruited. All of the participants were assessed by pulmonary function tests. Skin prick tests including common aeroallergens were performed to all patients. Results: No differences were found in pulmonary function test parameters between obese and lean patients with asthma. In obese patients with asthma, the ratio of forced expiratory volume in 1 s to forced vital capacity (FEV1/FVC) was significantly lower in nonatopic (92.1+/-6.4) than in atopic patients (95.5+/-5.3, p=0.02). We also demonstrated that FEV1/FVC was significantly lower in nonatopic obese patients (92.1+/-6.4) than in nonatopic lean patients with asthma (95.6+/-4.7, p=0.05). Conclusion: Obesity does not seem to be affecting pulmonary function in children with well-controlled mild persistent asthma. However, airways of nonatopic obese asthmatics are negatively affected.