TR-Dizin İndeksli Açık & Kapalı Erişimli Yayınlar
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Item What are extraintestinal diagnostic tips in children with Crohn's disease?(2019) Canan, Oguz; Durdu, Murat; Canpolat, TubaItem Chanarin Dorfman Syndrome: A Case Report(2015) Ozkale, Yasemin; Erol, Ilknur; Canan, Oguz; Durdu, MuratChanarin Dorfman Syndrome is a multisystem inherited metabolic disorder associated with congenital ichthyosis and accumulation of lipid droplets in varios types of cells. Observation of lipid vacuoles in neutrophils (Jordan's anomaly) in peirpheral blood smears in patients with ichthyosis is diagnostic for Chanarin Dorfman Syndrome. Since the initial case was reported by Dorfman in 1974, nearly 50 cases have been reported in the literature, and the majority were from Middle East countries. In this report we presented a 5 year old patient who admitted to our hospital for creatine kinase elevation and diagnosed as Chanarin Dorfman Syndrome with clinical and laboratory findings.Item Cytology in the Diagnosis of Dermatological Diseases: Tzanck Smear(2016) Durdu, Murat; 0000-0003-1247-3932; H-9068-2019Cytology is a simple, quick, reliable, and inexpensive diagnostic method based on the investigation of characteristic features of individual cells. In this diagnosis method, cellular materials are obtained by scraping method, slit-skin smear, touch smear or fine needle aspiration method according to the types of skin lesions. Obtained materials are immediately spread onto microscopic slide as a thin layer. Slides were stained with various cytological dyes, and examined under the light microscope. Until today, dermatological cytology has been used in the diagnosis of various erosive-vesiculobullous, pustular, granulomatous, and tumoral skin lesions. In this review article, the sampling methods for dermatological cytology were described, and the cytologic findings of skin diseases which could provide a rapid diagnosis were discussed.Item Role of Latex Hypersensitivity in Patients with Chronic Urticaria(2016) Durdu, Murat; Seckin, Deniz; 0000-0003-1247-3932; H-9068-2019Objectives: In this study, we aimed to determine the frequency of latex hypersensitivity in patients with chronic urticaria and to investigate the effect of latex-cross reacting food on the clinical course of the disease. Methods: This study includes 100 patients who admitted to our dermatology clinic with chronic urticaria, 100 health care providers and 100 healthy individuals. In patients with chronic urticaria, latex skin prick test was performed in addition to routine laboratory investigations. In the control group, prick test was performed only with latex. Changes in urticaria activity scores before and after latex containing products and cross reacting food restrictions were statistically compared in patients with urticaria. Results: Latex skin prick test was positive in 4 (4%) patients with urticaria and in 10 (10%) health care providers. Positive reaction was not observed in the healthy control group. Latex hypersensitivity in patients of urticaria was higher than healthy individuals, but the difference was not statistically significant. Urticaria activity scores did not change significantly after avoiding latex-cross reacting foods and latex-containing products. Conclusion: Latex hypersensitivity in patients with chronic urticaria was not found to be higher than the healthy individuals. In latex-sensitive patients, avoidance of latex-cross reacting foods and latex-containing products do not change the clinical course of the disease.Item Cytologic Findings of Eosinophilic Dermatoses: a Retrospective Analysis of 88 Patients(2016) Durdu, Murat; 0000-0003-1247-3932; H-9068-2019Objectives: Eosinophilic skin infiltration may develop as a result of a variety of infectious, inflammatory, and neoplastic diseases. To distinguish these diseases histopathologic examination is usually considered. So far, only a few studies have investigated cytologic findings of some eosinophilic diseases. In this retrospective study, our aim was to define the cytologic findings of eosinophilic dermatoses and to develop an algorithmic approach based on the cytologic findings. Methods: Patients who applied to the dermatology polyclinic through January 2010 to January 2015 could not be diagnosed only by clinical examination were further evaluated with May-Grunwald-Giemsa-stained preparations by a dermatologist. Patients with abundant eosinophils in microscopic examination were included in this study. After routine cytologic examination additional staining was also performed in some of these patients. The final diagnosis was established according to their clinical laboratory and histopathologic findings. Results: Over a 5-year period, 88 of 3.214 patients (2.7%) who underwent cytologic examination at our center had plenty of eosinophils. According to the final diagnoses, 44 lesions (50%) were spongiotic dermatitis, 17 lesions (19.3%) were infectious diseases, 13 lesions (14.8%) were autoimmune bullous, 11 lesions (12.5%) were idiopathic eosinophilic diseases, and 3 lesions (3.4%) were granulomatous diseases. Conclusion: Cytologic examination of people with eosinophilic skin diseases cytologic findings accompanying eosinophils could help for diagnosis of some diseases.Item Quick cytological diagnosis and rapid improvement with imiquimod cream in a case of orf infection(2016) Durdu, MuratOrf is a viral infection caused by the orf virus known to be the largest DNA virus that belongs to the Parapoxvirus genus. The disease occurs 3-7 days after contact with sheep and goats. Lesions usually resolve spontaneously within 6-8 weeks. On the other hands, infection may show progressive course in immunosuppressed patients. It has been reported that imiquimod cream can provide rapid improvement. We present the case report of a 48-year-old woman who developed erythematous nodular lesions two days after contact with animal. Tzanck smear examination was performed from nodular lesion, and cytoplasmic inclusions (Guarnieri bodies) were detected. The lesion rapidly resolved with topical imiquimod cream.Item Filler Reactions: Case Report and Review of the Literature(2017) Durdu, Murat; Bozca, Cansu; Kocer, Nazim Emrah; 0000-0003-1247-3932; 0000-0002-5943-9283; H-9068-2019; AAM-5436-2021A gradual increasing interest in cosmetic procedures and the implementation of these practices by non-physicians have led to the development of various complications. Some of these complications are transient, while others require severe systemic treatments, and some may be life-threatening. These complications cause depression and isolated from society. In this article, three different reactions in the light of literature data due to the application of vitamins E, which are not fillers, have been presented and reactions of filler substances and treatment approaches are reviewed.Item A misleading cutaneous lesion for the surgeon: pyoderma gangrenosum(2018) Solmaz, Gullu Korkmaz; Cologlu, Harun; Durdu, Murat; Ertas, Nilgun; 0000-0003-1247-3932; H-9068-2019; AAO-4286-2020Pyoderma gangrenosum is a rare inflammatory skin disorder characterized by cutaneous papulo-pustules that evolve rapidly into large, painful, necrotic ulcers. These lesions are often initially diagnosed as wound infection and necrotizing fasciitis. Debridement, although the standard of care for wound infections, is paradoxically detrimental in pyoderma gangrenosum because of pathergy. Early diagnosis and treatment of pyoderma gangrenosum is very important because unnecessary debridement and associated morbidity can be prevented. Herein, we report a case with pyoderma gangrenosum mimicking necrotizing fasciitis.