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    Parotid gland tuberculosis accompanied by brucellosis
    (2021) Inan, Serhat; Caylakli, Fatma; Canpolat, Tuba; 0000-0002-7333-2896; 0000-0001-8821-4481; AAP-7195-2020; AAJ-1407-2021
    Almost one-fourth of the world's population is latently infected with Mycobacterium tuberculosis (MTB) with approximately 3% to 15% people at risk of progression to active disease during their lifetime. Parotid gland tuberculosis (TB) is an extremely rare form of extrapulmonary TB even in endemic areas. Parotid gland TB presents clinically as a unilateral, slow-growing, and possibly painless mass. Parotid gland TB tends to mimic parotid tumors without pathological evaluation. Risk factors for active infection in extrapulmonary TB forms are human immunodeficiency virus, malnutrition, diabetes mellitus, smoking, alcoholism, hematological malignancies, and immunosuppressive treatments. Brucellosis is a systemic disease that is transmitted from unpasteurized milk and dairy products obtained from an infected animal. It can affect many organs. Brucellosis is difficult to diagnose because its signs and symptoms are nonspecific and mimic many diseases. The aim of this case report is to present the clinical features, pathophysiology, diagnostic process, and treatment of a parotid gland TB case accompanied by brucellosis, the diagnosis and treatment of which were based on the suspicion of the clinician, in the light of the literature.
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    Could there be an association between chronic brucellosis and endothelial damage?
    (2015) Togan, Turhan; Ciftci, Ozgur; Turan, Hale; Narci, Huseyin; Gullu, Hakan; Arslan, Hande; 25596571
    Introduction: In this study, we examined the effects of Brucella infection on endothelial dysfunction. Flow-mediated dilatation (FMD) measurement is indicator of the endothelial function, and abnormal values indicating endothelial dysfunction are accepted as the first stage of atherosclerosis. Methodology: Twenty-four patients who had been treated for acute brucellosis two years before, and who had had no relapses in the follow-up, were prospectively included in the study, along with 30 healthy individuals in the control group. Results: While the highly sensitive Creactive protein (hs-CRP) value was 2.42 +/- 1.45 in the patient group, it was 1.72 +/- 0.61 in the control group (p = 0.025). While the FMD value was 3.50 +/- 1.58 in the patient group, it was 5.88 +/- 1.88 in the control group (p < 0.001). While the percentage increase in FMD was 9.88 +/- 4.92 in the patient group, it was 17.49 +/- 6.3 in the control group (p < 0.001). It was observed that FMD value, the percentage increase in FMD, and basal radius were correlated with hs-CRP (r = -0.644, p < 0.001; r = -0.558, p = 0.002; r = 0.444, p = 0.018, respectively). The carotid artery intima media thickness (IMT) value was found to be 0.61 +/- 0.17 in the patient group and 0.49 +/- 0.12 in the control group (p = 0.004). Conclusions: The abnormal FMD and IMT values observed in brucellosis patients might be an indicator of more frequent arterial dysfunction, increased cardiovascular risk, and atherosclerosis.