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Item The Association Of Vitamin D Deficiency With Hemogram-Derived Inflammatory Biomarkers In Children*(2022) Konuksever, Dilek; Karakaya, Sevinc Pueren Yuecel; Boeluek, Oguz; Kocak, Mesut; Kilic, Betuel Orhan; Sac, Rukiye Uensal; 35973886Background and aims: One of the extraosseous effects of vitamin D is that it is a potent modulator of inflammatory processes. Many studies have demonstrated the inverse association between vitamin D and inflammation. Therefore, we hypothesize that vitamin D deficiency may affect the inflammatory markers derived from hemogram parameters [neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR), platelet dis-tribution width (PDW), red blood cell distribution width (RDW)] in healthy children.Methods and results: We conducted a retrospective study on healthy children. From 2015 to 2020, 16,321 children with simultaneous vitamin D and hemogram measurements were identified from electronic records. Participants were divided into 2 groups according to whether they had vitamin D deficiency or not. The relationship between vitamin D status and the levels of in-flammatory markers was analyzed. All inflammatory markers showed statistically significant dif-ferences between vitamin D status (p < 0.001 for all). Vitamin D levels were significantly negatively correlated with NLR (r =-0.285), PLR (r =-0.257), PDW (r =-0.181), and positively correlated with LMR (r = 0.218), and RDW (r = 0.057). In logistic regression analysis, age (OR = 1.15, 95% CI: 1.14-1.16), gender (OR = 1.66, 95% CI: 1.54-1.78), LMR (OR = 0.96, 95% CI: 0.95-0.98), PLR (OR = 1.003, 95% CI: 1.001-1.004), and RDW (OR = 1.10, 95%CI: 1.07-1.13) were found to be independent predictors for vitamin D deficiency.Conclusions: Statistically significant differences were detected between vitamin D status and in-flammatory parameters. However, the difference between the median values of vitamin D groups was very small and the degree of correlation was very weak. Therefore, the clinical significance of the difference should be questioned.(c) 2022 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Ital-ian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.Item The effect of vitamin D and melatonin on the ocular tissues in streptozotocin - Induced diabetes model in rats(2022) Bilgin, S.; Sivrikoz, O. Nermin; Cavdar, E.; Cetin, O.; 0000-0001-7454-2812; 35442492; V-9335-2017OBJECTIVE: The aim of the study was to investigate the effectiveness of vitamin D and melatonin on the ocular tissues in streptozotocin (STZ)-induced diabetes. MATERIALS AND METHODS: In this study. a total of 45 male Wistar rats were randomly divided into five groups as follows: 1) non-diabetic rats (control group); 2) untreated STZ-induced diabetic rats: 3) STZ-induced diabetic rats treated with vitamin D; 4) STZ-induced diabetic rats treated with melatonin; 5) STZ-induced diabetic rats treated with the combination of vitamin D and melatonin. After six weeks of treatment, all rats were sacrificed for post-mortem analyses. Retinal and corneal samples were obtained and analyzed for glial fibrillary acidic protein (GFAP) expression. Retinal and corneal thicknesses in addition to morphological changes were assessed via hematoxylin and eosin staining. RESULTS: Untreated diabetic rats revealed retinal disorganization, atrophy, increased vascularization along with more GFAP staining. However, all the treated groups exhibited more regular retinal layers and minimal GFAP staining. Additionally, treatment groups showed more uniform corneal layers with minimal GFAP staining. CONCLUSIONS: Melatonin and vitamin D could be used as an additional complementary treatment in diabetes. Developing treatment protocols involving supplementation, as well as informing patients about the potential benefits of vitamin D and melatonin could be impactful in the treatment process of diabetes.Item The Effect of High Dose Vitamin D on the Sympathetic Skin Response in Rats(2022) Masud, Haifa; Dolu, NazanItem The Effects of High Dose Vitamin D and Zinc on Anxiety and Exploratory Activity in Rats(2022) Baroud, Amna Abdulsalam; Dolu, NazanItem Comparison between the use of vitamin d supplement by 20-49 year old women and their nutrition and depression status(2021) Soykurt, Seniha Cukurovali; Tayfur, Muhittin; Celen, Emine UlucamObjective: Aim of this study is to determine the possible relation between the nutritional status, food choices, eating habits, and Vitamin D supplement use of pregnant women between 20-49 years of age, and depression. Methods: The study was conducted between December 2018 and January 2019, on a total of 150 pregnant women between the ages of 20 and 49, who were admitted to Ankara Ataturk Training and Research Hospital Obstetrics and Gynaecology Policlinic. A questionnaire was used in order to identify personal data of the individuals, levels of serum Vitamin D, depression status, physical changes and other information regarding the changes in food consumption. Dietary habits and food consumption records of the individuals were obtained through face-to-face interviews. Results: A total of 75 individuals participating in the study used Vitamin D, while the other 75 did not. Of the individuals participating in the study, beck depression score median of those who used Vitamin D was found as 9.00 (IQR =6), while it was 33.00 (IQR =13) for those who did not. When the scores were analyzed based on Vitamin D use, it was found that there were statistically significant differences. Conclusions: There is evidence from epidemiological studies that show that vitamin D deficiency or insufficiency is associated with depression. Therefore, it is appropriate to recommend taking vitamin D supplements to prevent or treat depression in risk groups. Larger studies are needed to examine this situation in detail.Item The effect of ultraviolet index measurements on levels of vitamin D and inflammatory markers in pregnant women(2021) Balci, SerdarBackground: Hypovitaminosis D is a risk factor for infertility and several adverse pregnancy outcomes. These negative effects of vitamin D deficiency may be due to inflammatory processes. T lymphocytes play a key role in the formation of immune response by producing some cytokines. Vitamin D is known to have significant effects on T lymphocytes and T regulator cells. The most significant determinant of vitamin Din the human body is sun exposure. The most important indicator determining the sun exposure in a region is the ultraviolet index (UVi). We tried to determine the effect of UV changes on vitamin D values during pregnancy and possible effects on inflammatory markers in a single region. Methods: The vitamin D serum values and blood count values of pregnant patients at the time of first admission were recorded in the months of April to September (AS) and October to March (OM). The daily UVi values of the Izmir region were obtained. These daily values were averaged according to the two groups. As inflammatory markers, the Neutrophil-Lymphocyte ratio (NLR), Platelet-Lymphocyte ratio (PLR), Monocyte-Lymphocyte ratio (MLR), mean platelet volume (MPV) and erythrocyte volume distribution (RDW) values were calculated from the blood count. Results: The UVi mean value was found to be 8 for AS and 3 for OM. There was a significant difference in the mean vitamin D values for the AS (42 patients) and OM (40 patients) periods. A predisposition to inflammatory processes was determined for the OM period in terms of the inflammation markers examined between the two groups. Our study showed lower levels of RDW and MPV and similar values for NLR, PLR and MLR according to the UVi values. Discussion: Vitamin D plays role in many systems as a hormone, a vitamin or an immunomodulator after activation in the skin tissue. Besides its known benefits to the musculoskeletal system, adequate serum vitamin D values reduce the risk of certain types of cancer, mental disorders, infectious diseases, cardiovascular diseases, type 2 diabetes mellitus, autoimmune disorders and adverse pregnancy outcomes. Additionally, lower UVi may be associated with lower vitamin D values in pregnant women and increased inflammatory markers in complete blood count. As a result, in order to avoid adverse pregnancy outcomes, the UVi values of regions may be useful for determining replacement of vitamin D during or before pregnancy.Item Evaluation of bone mineral density and its associated factors in postpartum women(2019) Eroglu, Semra; Karatas, Gulsah; Aziz, Vusale; Gursoy, Aybala Fatma; Ozel, Sule; Gulerman, Hacer Cavidan; 31759531; AAD-8353-2020Objective: Although osteoporosis commonly appears among postmenopausal women, it is rarely diagnosed during the postpartum period as pregnancy-lactation associated osteoporosis (PAO). The aim of the study reported here was to investigate low bone mineral density and its associated risk factors in postpartum women. Materials and methods: The sample consisted of 93 females aged 18-40 years and in the first month of the postpartum period. All the women had low back pain. The bone mineral density (BMD) Z-score values of the lumbar vertebrae, femur (neck and total) were examined using dual energy x-ray absorbtiometry four weeks after birth. Patients body mass index (BMI), 25-hydroxyvitaminD (25-OHD) levels and complete blood counts were recorded. Participants were divided into two groups to their Z scores: the normal group (n = 71) and the low BMD group (n = 22). Results: The 25-OHD levels were significantly lower (p = .02) in the low BMD group [4.45 (4.0-12.4)] than in the control group [22 (12-48)], however, NLR and PLR values were similar between groups. BMI positively correlated with BMD scores for the lumbar, femoral neck and femoral overall (p = .011, p = .026 and p = .026, respectively). Conclusion: Vitamin D deficiency and BMI may play a critical role in PAO. Low back pain during postpartum period should be carefully evaluated. Adequate calcium and vitamin D supplementation may prevent possible bone loss. (C) 2019 Taiwan Association of Obstetrics & Gynecology. Publishing services by Elsevier B.V.Item Vitamin D Related Musculoskeletal System Findings(2015) Sarifakioglu, Banu; Yalbuzdag, Seniz Akcay; Guzelant, Aliye Yildirim; Afsar, Sevgi Ikbali; Ustaomer, KubraObjective: The effect of vitamin D on bone metabolism has been well known for a long time. Recently, various hormonal and immunity related effects has have been obtained. Additionally, the deficiency of vitamin D is thought to be related with various pain syndromes. In this study, we aimed to investigate the main musculoskeletal symptoms of patients with vitamin D deficiency admitting to physical medicine and rehabilitation clinics. Materials and Methods: The data were retrospectively investigated in patients with myalgia, arthralgia, regional pain, widespread body pain (WBP) and in whom vitamin D levels were measured. Patients over 50 years old and with known osteoporosis/osteomalacia diagnosis, endocrinological pathology, and inflammatory rheumatological disease were excluded. Results: The data of 571 patients were investigated and totally 214 of them were included in the study. There were 178 females (83.2%), 36 males (16.8%). The mean age of the patients was 39.19 +/- 9.58 years. Of the patients, 100 (46.7%) were in severe deficiency, 68 (31.8%) were in deficiency, 46 (21.5%) were in insufficient group. The symptoms were regional pain in 65 (30.3%), WBP in 63 (29.4%), arthralgia in 49 (23%), and myalgia in 37 (17.3%) patients. Conclusion: Vitamin D deficiency may be encountered as musculoskeletal problems. In the presence of persistent joint-muscle pain, regional pain and fibromiyalgia, vitamin D deficiency should be kept in mind.Item Sadfly fever: two case reports(2016) Ozkale, Yasemin; Ozkale, Murat; Kiper, Pinar; Cetinkaya, Bilin; Erol, Ilknur; 0000-0002-3530-0463; 0000-0003-0866-7339; 0000-0003-3009-336X; 0000-0003-0625-1057; 27489469; AAK-4825-2021; AAF-1346-2021; AAL-6136-2021; A-7806-2016Sandfly fever, also known as 'three-day fever' or 'pappataci fever' or 'Phlebotomus fever' is a viral infection that causes self-limited influenza-like symptoms and characterized by a rapid onset. The disease occurs commonly in endemic areas in summer months and especially in August during which sandflies are active. In this article, two siblings who presented with high fever, redness in the eyes, headache, weakness, malaise and inability to walk, who were found to have increased liver function tests and creatine kinase levels and who were diagnosed with sadfly fever with positive sadfly IgM and IgG antibodies are reported because of the rarity of this disease.