Araştırma Çıktıları | TR-Dizin | WoS | Scopus | PubMed
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Item Microscopic study of human nasal cavity microanatomy using semi-thin resin embedding and methylene blue staining(2019) Firat, Aysegul; Onerci-Celebi, Ozlem; Tuncel, Alican; Ergun, Mine; Hayran, MurvetThe nasal cavity is a part of the respiratory tract which humidifies, filters, and warms the air we breathe, as well as being the organ of olfaction. It is easily accessible in terms of morphological and histopathological evaluation for clinical and research purposes. There have been many studies and textbooks showing the histological evaluation of the nasal cavity's three functional regions: the vestibule, respiratory, and olfactory. The present study aimed to examine the nasal mucosa in a detailed manner in 11 predetermined anatomic areas. Specimens were collected from six fresh-frozen cadavers using a standard punch biopsy procedure. Microscopic evaluation was done on the nasal mucosa, glands, blood vessels, muscles, connective tissue, and neural anatomy. Also, examined and described were the epithelial cell and glandular transitions in the mucosal lining. The microscopic investigation of these features in the nasal cavity provided important information for both clinical and research purposes.Item Non-Hematologic Malignancies Metastasing to the Bone Marrow: A Record-Based Descriptive Study From A Tertiary Center(2019) Aytan, Pelin; Kocer, Nazim Emrah; Yeral, Mahmut; Gereklioglu, Cigdem; Kasar, Mutlu; Buyukkurt, Nur Hilal; Asma, Suheyl; Ozdogu, Hakan; Boga, CanThe aim of this study is to assess the cases of nonhematologic maiignancies that had bone marrow (BM) metastasis with respect to hematologic abnormalities, radiologic findings and pathologic findings. All of the patients with BM investigation were retrospectively evaluated. The patients with BM metastasis by a non-hematologic malignancy were assessed. Data regarding patient characteristics including peripheral blood evaluation findings, imaging findings, BM evaluation results and survival were obtained from patient files and computer based electronic database. 30 cases were detected among 1831 BM aspirations and biopsies. The most common malignancies were breast (36.7%), prostate (13.3%), gastric(13.3%) and lung (13.3%) adenocarcinomas. 90.9% and 75% of the cases had positive radiologic findings with PET/CT and CT respectively. 43.3% of the patients died during the study period and the median time from BM assessment to death was 2 months. Anemia, thrombocytopenia and leukopenia were present in 90%, 73.3% and 20% respectively. Lactate dehydrogenase and alkaline phosphatase were elevated in 90% and 80% respectively. In 76.2% a leukoerythroblastic blood picture was present. All the cases were diagnosed with biopsy and aspiration detected infiltration in 40% and in 4 metastatic patients (13.3%) the aspiration was false negative. In 46.7% the aspiration resulted with dry tap. Grade 3 fibrosis was present in 76.7%. BM assessment is a minimally invasive technique and provides very beneficial clinical data, however, because the survival is very short after BM assessment and the PET/CT has a considerable sensitivity it is not necessary to confirm BM metastasis in patients whose tumor stage is already known.