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Item The relationship between premature ejaculation and the timing of pre-adult circumcision(2021) Ongun, Sakir; Esen, Emre Cem; Ozer, Muhammed Selcuk; Yildirim, Omer; Hasirci, Eray; Sah, Cem; Sahin, Bahadir; Duran, Mesut Berkan; Cinar, Onder; Cihan, Ahmet; Kazaz, Ilke Onur; Gul, Umit; Deliktas, Hasan; Kizilkan, Yalcin; Altunkol, Adem; Kurt, Hasan Anil; Tosun, Cagatay; Bozkurt, Ozan; Turunc, Tahsin; Akkus, Emre; 0000-0002-4147-2966; 0000-0003-3249-0895; 33709439; AAI-7997-2021; AAK-8394-2021We aimed to investigate the relationship between premature ejaculation and the age when men had been circumcised before adulthood. A total of 2,768 sexually active male patients aged between 18 and 65 years were included in this study. A multicentre study was conducted prospectively with the participation of 20 centres. A survey consisting of 12 questions prepared by the researchers, as well as the validated Turkish versions of the five-item Premature Ejaculation Diagnostic Tool, was administered to all participants. The study included 1,603 participants who met the inclusion criteria. There was no significant difference in the Premature Ejaculation Diagnostic Tool and self-reported ejaculation time between the participants who had been circumcised at different ages during childhood. Remembering circumcision experience with fear or anxiety did not increase the risk of sexual dysfunction compared to the participants who described their experience with happiness or with no particular emotion. There was no significant difference in Premature Ejaculation Diagnostic Tool scores or the self-reported ejaculation time of the participants circumcised at different ages. The age of childhood circumcision, having a fearful or anxious circumcision experience, does not affect the risk of premature ejaculation in adult life.Item Squamous cell carcinoma of the penis: a clinicopathological study from a population with late circumcision(2019) Baydar, Dilek Ertoy; Akkaya, Hampar; Apa, Duygu Dusmez; Bal, Nebil; Demirsam, Asli; Gucluer, Berrin; Nese, Nalan; Sari, Aysegul Akder; Kirdar, Sevin; Akdogan, Bulent; Karabulut, Erdem; 31658325Squamous cell carcinoma (SCC) of the penis has been subject to only a few studies in populations where late childhood circumcision is performed. To asses clinicopathological features and human papillomavirus (HPV) status of penile SCC in men with late circumcision, eight institutions in the country volunteered to collaborate and 15 cases of penile SCC were collected from their pathology archives. The presence and genotype of HPV were determined in addition to clinicopathological features of the tumors. Findings were correlated with disease outcome. The mean age of the patients evaluated was 66.5 years. Histological subtypes were usual SCC (6/15), papillary (2/15), mixed (2/15), basaloid (2/15), acantholytic (1/15), pseudohyperplastic (1/15), and warty-basaloid (1/15) carcinomas. HPV was identified in 33.3% of samples; HPV16 was detected in 60% of positive cases and was associated with basaloid and/or warty morphology. Cause-specific 1-year and 2-year survivals were 76.9% and 54.5%, respectively. The usual subtype and nodal metastasis were associated with worse outcome (p=0.045 and p=0.047, respectively). As a conclusion, our results suggest an inclination for penile SCC to develop at a later age in a population with late circumcision than the patients from the regions of high penile cancer incidence. These men seem to have less frequent HPV association and their outcome appears poorer than other populations, although reaching substantial provision is not possible due to our limited case number.