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    Non-Tumoral Factors Affecting The Preference of Nephron-Sparing Surgery in The Treatment of Stage 1 Renal Cell Carcinoma Patients in Turkey
    (2021) Kuzgunbay, Baris; Yaycioglu, Ozgur
    Objective: Nephron-sparing surgery (NSS) is the first-line treatment for T1N0M0 renal tumors (RT). The aim of this multicentric retrospective study is to investigate the national trends and the effect of non-tumoral factors in the preference of NSS as treatment of T1 RT in Turkey. Materials and Methods: Relevant data for patients operated between 1997 and 2017 was collected from the Urologic Cancer Database-Kidney Urooncology Association, Turkey (UroCaD-K). Results: We included 3195 T1N0M0 RT patients in this study. There was a significant increase in the number of NSS performed with time, 9.26% between 1997-2002 to 54.78% between 2013-2017 (p<0.001). NSS proportion decreased with increasing age (p<0.001); but increased with better hospital facility (p<0.001). From multivariate analysis; younger age, later operation date, larger hospital size with higher nephrectomy centers like university hospitals were independently associated non-tumoral factors favoring NSS over radical nephrectomy (RN). Conclusion: We observed significant disparity in the use of NSS for T1 RT among the elderly (>61 years), small hospital size (<= 500 beds), lower nephrectomy volume (<100 nephrectomies/year), and Non-University Hospitals. This disparity can be resolved by persistent education of the residents and urologists with periodic courses and practical training, increasing the funds and strengthening the technical equipment of centers, thereby favoring the performance of NSS even in smaller centers. This will ensure that suitable patients are treated with NSS rather than RN, regardless of the hospital type.
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    Is Learning Curve Short for MicroTESE Operation in Nonobstructive Azoospermic Patients?
    (2016) Turunc, Tahsin; Kuzgunbay, Baris
    Aim: To evaluate learning curve in microdissection testicular sperm extraction (microTESE) surgery performed in non-obstructive azoospermia patients. Material and Method: The study included 300 non-obstructive azoospermic (NOA) patients, who underwent microTESE surgery performed by a single urologist. The patients were divided into three groups (the first 100 patients, the second 100 patients, and the third 100 patients) and these groups were compared in terms of sperm retrieval rate (SRR) and other clinical parameters. It was planned to compare the patients in first 99 patients between themselves in case there is no difference between the groups in terms of SRR. Results: The overall SRR was 47% in 300 NOA patients. No significant difference was determined between the three groups in terms of SRR (49%, 46%, and 46%, respectively). Accordingly, the first 99 patients were re-compared in terms of SRR (the first 33 patients, the second 33 patients, and the third 33 patients). It was observed that there is also no significant difference between these groups in terms of SRR (54.5%, 42.4%, and 51.5%, respectively). Moreover, no significant difference was determined between all of the groups in terms of patient age, testis volume, and serum follicle-stimulating hormone and testosterone levels. It was observed that duration of surgery has been significantly shortened in all groups as the number of surgical procedures increased. Discussion: Learning curve in microTESE surgery is shorter according to learning curves in other urological surgeries.
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    Percutaneous Nephrolithotomy for Kidney Stones in Patients with Hematological Malignancy
    (2016) Kuzgunbay, Baris; Turunc, Tahsin
    To define the alterations in the outcomes of percutaneous nephrolithotomy (PNL) operations for kidney stones in patients with history of hematological malignancy (HM). Material and Method: Between 2000 and 2013, 1700 adult patients underwent PNL for the treatment of kidney stones in our institution. Four of these patients had a history of HM and considered to be HM group (n=4). Ten elderly (>65 years) patients who had no history of operation, HM or any other co-morbide diseases were chosen as the control group (n=10). Surgical parameters, success rates, additional treatments and complications were evaluated. Results: Statistical analyses showed no significant differences between HM and control group according to stone area, operation time, fluoroscopy time, hospitalization time,Delta Hb, blood transfusion rates and INR values (p>0.05). Statistical analyses revealed no significant differences between HM and control groups according to the success rates (p=0.470). Statistical analyses revealed no significant difference between groups for additional treatment requirements (p=0.882). No major perioperative complication was seen in both of the groups. Discussion: The treatment of kidney stone disease by PNL in patients with hematological malignancy is feasible, safe and effective. However, close cooperation with the Hematology Department before the operation is mandatory.