Wos İndeksli Açık & Kapalı Erişimli Yayınlar

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Subject: search.filters.subject.papilloma

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    Sinonasal inverted papilloma: Recurrence, surgical management, and mini review
    (2021) Olgun, Levent
    Objective: Sinonasal inverted papilloma (SIP) has a high rate of recurrence and a potential to be transformed into a malignant disease, hence surgery is the treatment of choice. In this study, we aimed to identify the preoperative features of patients diagnosed with SIP and discuss treatment options, recurrence rates, and postoperative clinical outcomes. Methods: Twenty-six patients who were diagnosed with SIP between 2010 and 2014 in a training and research hospital were included in the study. Their charts were reviewed retrospectively. The complaints at admission, findings of anterior rhinoscopy, nasal endoscopy, and radiological examinations were recorded along with histopathological features. Different surgical treatment modalities and recurrence rates were analyzed regarding tumor characteristics and postoperative outcome. Results: The average postoperative follow-up was 32.1 +/- 20 months. According to Krouse classification, 15 (57.7%) patients were staged as T3, eight (30.8%) were T2, and three (11.5%) were T1. Endoscopic sinus surgery was performed in 21 patients. Medial maxillectomy via lateral rhinotomy (classical technique) was performed in five patients. Two patients (7.7%) who had endoscopic surgery had a recurrence of SIP; however, the rate was not statistically significant when compared with that of patients who underwent the classical technique. Histopathological examination revealed chronic rhinosinusitis with nasal polyposis (19.2%), squamous metaplasia (3.8%), and squamous cell carcinoma (7.7%) concurrent with SIP. Conclusion: Endoscopic surgery should be the first choice for the treatment of SIP. It may be combined with classical methods in some patients with advanced stage disease, especially when the tumor spreads to areas that are difficult to reach. Following surgical intervention, the patients should be followed carefully to identify recurrence or malignant transformation as early as possible.
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    Detection of HPV DNA in Esophageal Lesions: a Cross-Sectional Study
    (2020) Dinc, Bedia; Altay-Kocak, Aylin; Aydog, Gulden; Kuran, Sedef; Akoglu, Musa; Ozkan, Secil; Bozdayi, Gulendam; 32162873
    Background: Several studies have documented human papillomavirus (HPV) in extra-cervical tumors. We aimed to detect HPV type 16 and HPV other than type 16 (OT-16) DNA in esophageal papilloma and esophagus squamous cell carcinoma (ESCC) samples and to compare clinicopathological features of HPV positive and negative patients. Methods: Materials were obtained from a tertiary care public hospital and studied in an university hospital for this cross-sectional study. Seventy-six tissue samples (50 papilloma and 26 ESCC) were included. After deparaf-finization by xylene and DNA extraction by phenol chloroform-isoamyl-alcohol, 76 samples were studied with a G6PDH control kit. Forty-four papilloma and 21 ESCC samples with enough tissues were studied for HPV DNA. HPV OT-16 DNA and HPV type 16 were detected by real time-polymerase chain reaction. Results: Twelve (27.3%) and one (2.3%) of the papilloma samples were HPV type 16 and other than type 16 positive, respectively. Eleven (52.4%) and one (4.8%) of ESCC samples were HPV type 16 and mixed type positive, respectively. Conclusions: We suggest that HPV infection is common in esophageal papilloma and ESCC. Due to the wellknown association of HPV with premalignant and malignant conditions, follow-up of these patients accompanied by HPV should be implemented.