Wos İndeksli Açık & Kapalı Erişimli Yayınlar

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    Protective Effect of Spirulina on Cisplatin-Induced Ototoxicity: A Functional and Histopathological Study
    (2022) Tahir, Emel; Buyuklu, Adnan Fuat; Ocal, Fatma Ceyda Akin; Gurgen, Seren Gulsen; Sarsmaz, Hayrunnisa Yesil
    Objective: The purpose of this study was to evaluate the protective effect of an antioxidant and anti-inflammatory agent, "spirulina," against cisplatin-induced ototoxicity in rats. Methods: Twenty-eight adult Sprague-Dawley rats were divided into 4 groups. Before drug administration, distortion product otoacoustic emission and auditory brainstem response tests were performed. Group 1 (n =7) received 1 mg of intraperitoneal saline. Group 2 (n=7) received a single dose of intraperitoneal cisplatin at 15 mg/kg/day. Group 3 (n=7) received oral spirulina at 1000 mg/kg/day for 10 days. Group 4 (n=7) received a single i.p. dose of cisplatin at 15 mg/kg/day, followed by 10 days of oral spirulina at 1000 mg/kg/day. The final distortion product otoacoustic emission and auditory brainstem response measurements were provided 10 days after the initial drug administration. Cochleas were removed, the histochemical examination was performed by caspase-3, caspase-9, and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling methods. Results: Initially, there were no significant differences in distortion product otoacoustic emission and auditory brainstem response measurements between groups. Following cisplatin treatment, the mean difference in signal to noise ratio values was lower in the cisplatin + spirulina group compared to the cisplatin-only group. The increase in auditory brainstem response thresholds was more significant in the cisplatin-only group than in the cisplatin + spirulina group. Posttreatment auditory brainstem response latencies were prolonged in cisplatin and cisplatin + spirulina groups; however, a significant difference was obtained between these 2 groups. The cisplatin + spirulina group had a lower density of apoptotic cells than the cisplatin-only group. Conclusion: Spirulina has no adverse effects on cochlear functions and may provide some protection against cisplatin-induced ototoxicity.
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    TURKISH-COFFEE ENRICHED WITH ROSE: A PROMISING COMBINATION
    (2019) Karabudak, E.; Aksoydan, E.; Agagunduz, D.; Ergul, M.
    The purpose of this study was to develop a new & healthy version of Turkish-coffee enriched with rose. Conventionally roasted Coffee Arabica L. beans for Turkish-coffee & dried-Rosa Damascene Mill. [7 / 0,7 / 0.5,7 / 1.5,7 / 2g(w / w)] was grinded. Total-Phenolic Contents (TPC), Total-Antioxidant (TAS) & Oxidant-Status (TOS) were measured and Oxidatif Stress Index (OSI) was calculated. Consumer panel testing was done. TPC of the coffee samples with 1.5 & 2g rose was different according to plain coffee (p<0.05). TAS value (mmol/L) of plain-coffee was 2.2 +/- 0.11 while the values of the coffees including 0.5g,1.5g,2g rose were 2.4 +/- 0.09,2.4 +/- 0.05,2.7 +/- 0.02, respectively. TOS value (mu mol/L) of plain-coffee was 17.6 +/- 0.24, while the values of the coffees including 0.5 g, 1.5 g and 2 g rose were 13.0 +/- 1.00, 9.4 +/- 1.30, 9.4 +/- 0.31, respectively (p<0.05). OSIs of coffee samples including 0, 0.5, 1.5, 2 g rose were found to be 7.7, 5.2, 3.6, 2.7 respectively (p<0.05). The coffees including 1.5 & 2 g rose had the highest sensory-scores. Turkish-coffee including rose will strengthen already existing phenolic & antioxidant features of coffee, and thus contribute the improvement of health & taste.