Wos İndeksli Açık & Kapalı Erişimli Yayınlar
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Item Effect of rosuvastatin on spatial learning, memory, and anxiety-like behaviour in ovariectomized rats(2022) Emre-Aydingoz, Selda; Lux, Karl Michael; Efe, Oguzhan Ekin; Topcu, Deniz Ilhan; Erdem, Saban Remzi; 0000-0001-7823-7620; 0000-0002-3243-7843; 0000-0002-1219-6368; 35993621; ABA-4291-2020; W-7908-2019; E-3717-2019The effect of rosuvastatin (Ros) on cognitive function and anxiety-like behaviour in ovariectomized rats were evaluated. Eighteen female Wistar rats (218-310g, 6-8 months old) were allocated into sham (n = 6), ovariectomy (Ovx, n = 6) or Ovx + Ros (up to eighth week n = 6, then n = 4) groups. Ros was administered at 20 mg/kg/day by oral gavage for 12 weeks. Behavioural tests were performed at 4, 8 and 12 weeks following Ovx. At 12weeks, Ovx group had significantly longer escape latency than the sham group at the first day of the four-day training period of the Morris Water Maze test (p < .01). In the Elevated Plus Maze test, Ovx group spent significantly more time in the closed arms than the sham group (p < .01), and this anxiety-like behavioural effect of Ovx was prevented by 12-weeks Ros treatment (p < .05). In conclusion, Ros prevents memory deficit and anxiety-like behaviour in the ovariectomized rats, a model for human surgical menopause.Item Anxiety, depression, and sexual dysfunction in patients with psoriasis(2022) Dogan, Yusuf; Kilic, Fatma; Ozcelik, SinanBackground: There are few studies investigating the association between psoriasis and depression, anxiety, sexual dysfunction in the literature. Aims: We aimed to investigate depression, anxiety, and sexual dysfunction in patients with psoriasis and the association between the psychiatric comorbidity and the severity and involvement sites of psoriasis. Materials and Methods: A total of 200 participants, including 100 psoriasis patients and 100 healthy volunteers as a control group, were included in the study. All participants were questioned about sociodemographic characteristics, smoking, alcohol use, and comorbidities. All participants completed the Dermatology Life Quality Index, Beck Depression Scale, Beck Anxiety Scale, Arizona Sexual Experiences Scale, Female Sexual Function Scale/International Erectile Function Index. Results: In the psoriasis group, an increased risk for depression and anxiety was observed, regardless of the clinical features and severity of psoriasis, and a positive correlation was detected between the severity of the disease and impaired quality of life. An increased risk for sexual dysfunction regardless of clinical features and severity in male patients with psoriasis was detected compared with the control group. It was found that the risk for erectile dysfunction in patients with psoriasis increased regardless of the risk factors such as smoking, alcohol, diabetes, hypertension, and cardiovascular disease. Conclusion: Our study shows that psoriasis increases the risk for impaired quality of life, depression, anxiety, and sexual dysfunction in individuals. This increase is not always associated with the clinical characteristics of psoriasis such as severity, duration, and sites of involvement. Therefore, dermatologists should consider not only the skin findings of psoriasis but also the psychosocial status of the patient and refer the patient to psychiatry if necessary.Item Coexistence of restless legs syndrome and multiple sclerosis aggravates anxiety and depression(2022) Sevim, Serhan; Demirkiran, Meltem; Terzi, Murat; Yuceyar, Nur; Tasdelen, Bahar; Idiman, Egemen; Kurtuncu, Murat; Boz, Cavit; Tuncel, Deniz; Karabudak, Rana; Siva, Aksel; Ozcan, Abdulcemal; Neyal, Munife; Goksel Karakurum, Basak; Gazaloglu, Gulcan Baran; Balal, Mehmet; Sen, Sedat; Baklan, Meltem Alkaya; Gunduz, Tuncay; Tuncer, Asli; Uygunoglu, Ugur; 35195221Background: Among the comorbidities that accompany multiple sclerosis (MS), restless legs syndrome (RLS) is one of the most common. Anxiety and depression are common psychological comorbidities that impact the quality of life of patients with MS (PwMS), as well as patients with RLS. Objective: To investigate the psychiatric burden of MS and RLS coexistence, we conducted a nationwide, multicenter and cross-sectional survey. Methods: Participants were assessed by using demographic and clinical parameters along with the Hamilton Anxiety and Hamilton Depression Scales (HAM-A and HAM-D). Results: Out of the 1,068 participants, 173 (16.2%) were found to have RLS [RLS(+)] and 895 (83.8%) did not [RLS(-)]. The mean scores for HAM-A and HAM-D were significantly higher among RLS(+) subjects than among RLS(-) subjects (p<0.001 for all variables). Conclusions: According to our data, the presence of RLS in PwMS may increase the occurrence of both anxiety and depression symptoms. Awareness and treatment of RLS in PwMS could possibly reduce the symptoms of psychiatric comorbidities originating from RLS.Item Evaluation of Electrodermal Activity and Anxiety Behaviors in Diabetic Rats Given Vildagliptin and Metformin(2022) Shawesh, Muftah; Alshareef, Mohammed; Boyuk, Gulbahar; Yigit, Ayse Arzu; Dolu, NazanItem The effect of nursing care and follow-up for mothers of infants undergoing congenital heart surgery: a quasi-experimental study(2023) Ay, Ayse; Koc, Gulten; 36124651Improvements in congenital heart surgery have resulted in an increasing number of infants surviving, but there remain concerns about home care and difficulties experienced by mothers. This study was designed to evaluate the effect of nursing care and follow-up for the mothers of infants undergoing congenital heart surgery on anxiety, care burden, and self-efficacy. The study was designed as a quasi-experimental study with a pre-test and post-test control group design. The study included 40 mothers whose infants had undergone congenital heart surgery. Nursing care was provided to the mothers of the infants included in the study group through a total of six home follow-ups until the third month after surgery, guided by the North American Nursing Diagnosis Association and Nursing Diagnosis System and Nursing Interventions Classification. Data were collected through Care Needs Identification Form, Spielberger's State-Trait Anxiety Inventory, Zarit Burden Interview, and Parental Self-efficacy Scale. The mean State-Trait Anxiety Inventory and Zarit Burden Interview scores for the mothers in the intervention group decreased, while the mean Parental Self-efficacy Scale scores increased as the follow-up progressed and it was determined that by the third month, the difference between the mothers in the intervention group and those in the control group in terms of post-test State-Trait Anxiety Inventory, Zarit Burden Interview, and Parental Self-efficacy Scale had become statistically significant. Providing appropriate nursing care practices to the mothers of the infants had undergone congenital heart surgery in home setting has the potential to decrease the problems experienced by the mothers.Item The Effects of High Dose Vitamin D and Zinc on Anxiety and Exploratory Activity in Rats(2022) Baroud, Amna Abdulsalam; Dolu, NazanItem The relationship between pain and clinical parameters, depression, anxiety and sleep quality in patients with spinal injury(2022) Balikci, Sibel; Bardak, Ayse NurObjective: To examine the frequency of pain in individuals with spinal cord injury, and to assess the relationship of pain with functional status, sleep quality, anxiety and depression levels. Method: The prospective, cross-sectional study was conducted from March to June 2018 at Istanbul Physical Medicine and Rehabilitation Training and Research Hospital, Istanbul, Turkey, and comprised adult patients of wither gender with spinal cord injury who were in the rehabilitation phase both on outpatient and inpatient basis. Data was collected using a questionnaire exploring demographic and clinical features. The presence of pain was assessed using the Leeds Assessment of Neuropathic Symptoms and Signs scale and, in case pain was found present, it was categorised as neuropathic, nociceptive and mixed type pain types. Sleep quality was evaluated using the Pittsburgh Sleep Quality Index, while the Hospital Anxiety and Depression scale was used to evaluate anxiety and depression levels. Data was analysed using SPSS 20.Results: Of the 150 patients, 104(69.3%) were males and 46(30.7%) were females. The median age of the sample was 46 (IQR:20.52) years. Neuropathic pain was observed in 61(40.7%) patients, nociceptive in 32(21.3%) and mixed type in 12(8%). Depression was found in 71(47.3%) patients, poor sleep quality in 41(27.3%) and anxiety in 35(23.3%). Sleep, anxiety and depression scores were higher in the presence of neuropathic and nociceptive pain (p<0.05). Conclusion: Pain is a common complication in patients with spinal cord injury. In the presence of pain, sleep quality is worse, and anxiety and depression levels are high.Item Emotional and physical maltreatment, early maladaptive schemas, and internalizing disorders in adolescents: a multi-group path model of clinical and non-clinical samples(2021) Yigit, Ibrahim; Kilic, Harun; Guzey Yigit, Melike; Celik, Cihat; 0000-0003-0556-9960; W-5957-2018Many studies have supported the mediating role of maladaptive schemas in the relationship between early childhood adversity and psychopathology in both clinical and non-clinical adolescent samples. However, to the best of our knowledge, there has been no study to simultaneously test the mediating role of maladaptive schemas in a combined model included in both clinical and non-clinical samples of adolescents. The sample of the study consisted of 132 non-clinical (M = 15.65, SD = 1.15) and 193 clinically referred (M = 15.05, SD = 1.07) adolescents. Criteria for the clinical sample included being diagnosed with generalized anxiety disorder, depressive disorder or mixed anxiety and depressive disorder. Participants were administered The Childhood Trauma Questionnaire, Young Schema Questionnaire, Children's Depression Inventory, and Spielberger State-Trait Anxiety Inventory. The aim of the present study was to test the hypothesized mediation model that Disconnection/Rejection and Impaired Autonomy schema domains would mediate the relationship between childhood maltreatment and psychological symptoms for clinical and non-clinical adolescent samples, separately. Furthermore, we tested whether structural paths of the model were different across the two samples, using multiple-group path analysis. Results showed that Disconnection/Rejection and Impaired Autonomy emerged as significant mediators in both samples. In addition, only the association between Disconnection/Rejection and depression was stronger in the clinical sample compared to the non-clinical sample.Item Smoking Prevalence among Healthcare Workers and the Effects of the COVID-19 Pandemic Process on the Frequency of Smoking in Turkey(2021) Yildirim, Berna Botan; Torun, Serife; Akcay, M. Sule; 0000-0002-6530-6153; ABF-1652-2021This cross-sectional study aims to evaluate the prevalence of smoking among healthcare workers and to investigate the anxiety level of healthcare professionals who have knowledge of COVID-19-related mortality and morbidity and are burdened by the anxiety and stress caused by the pandemic, and its effect on their smoking habits. An online questionnaire was used to facilitate the participation of busy healthcare workers. The survey was shared on all health platforms and various social network groups (Facebook, WhatsApp, etc.) for doctors (specialists, physicians, residents, dentists), nurses, and all other healthcare workers This questionnaire consisted of two tests, namely the Beck Anxiety Scale (BAS) and the Fagerstrom Nicotine Dependence Test (FNDT), and sociodemographic questions. A total of 806 healthcare workers, of whom 74.2% were physicians, 8.8% were midwives/nurses, and 15.1% were assistant health workers, participated in the study. Among all the participants, 501 (62.1%) were nonsmokers, 305 (37.9%) were smokers, and 8(1%) resumed smoking during the pandemic. In terms of the smoking habits of the participants during the pandemic period, 34% of the women who smoked had increased their amount of smoking. With respect to the smoking cessation rates of the participants, the physicians had quit or reduced smoking more than the other participants. The rate of smoking cessation in our study was 2.23%. Among those who quit, 88.8% were doctors, and the rate of quitting among them was 7.8%.Item Increased Levels of Anxiety, Depression, and Secondary Trauma in Radiation Oncologists during COVID-19 Pandemic: A Preliminary Report from Turkey(2021) Topkan, ErkanOBJECTIVE We surveyed the anxiety, depression, and secondary trauma levels of Turkish Radiation Oncologists related with COVID pandemics. METHODS An anonymous online questionnaire survey was created to evaluate levels of depression, anxiety, and secondary trauma among Turkish Radiation Oncologists. The survey included demographics and occupational status, Secondary Traumatic Stress Scale (STSSS), The Beck Depression Inventory (BDI), The Beck Anxiety Inventory (BAI), and State-Trait Anxiety Inventory (STAI). RESULTS Seventy-two respondents provided the power of about 91.4% for the significance level of 0.05. The variance homogeneity was checked by the Levene test, the effect of COVID-19 on psychology is higher in the group of >19 (9.02 +/- 0.820), as well as the effect of social isolation (8.02 +/- 1.622), the STSS scores (34.28 +/- 9.062), the STAIS scores (60.46 +/- 5.296), the STAIT scores (82.21 +/- 9.298), the BDI scores (22.68 +/- 2.788), and the BAI scores (21.04 +/- 9.321). The multiple regressions to estimate BDI revealed statistically significant effects in STAIS, BAI, and STAIT. There is a significant correlation between STSS, STAIS, STAIT, BDI, BAI, the effect of COVID-19 on psychology, and the effect of social isolation. CONCLUSION We have established one of the first studies demonstrating the effects of COVID-19 pandemic on depression, anxiety levels, and secondary trauma on a special physician population, the Radiation Oncologists, who specifically do not directly take part in COVID19 management.