Wos İndeksli Açık & Kapalı Erişimli Yayınlar

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    Applicability of the Vienna Sale Agreement (CISG) for Advanced Purchase Agreements of COVID-19 Vaccines in EU Member States
    (2022) Cortoglu Koca, Sema
    The European Commission has signed advanced purchase agreements with various vaccine manufacturers for the production, purchase and supply of the COVID-19 vaccine in the EU. Some parts of the agreement texts with AstraZeneca, CurevacAg and Pfizer Inc./BioNTech have been blacked out. In these agreements, it is understood that Belgian courts are competent and Belgian law is chosen. In a dispute, it is possible for the competent courts to apply CISG since Belgium is a party to the CISG. Even if choice of law hasn't been made, the fact that the workplaces of all parties to these ageements are party to CISG, makes the CISG applicable. This study evaluates the applicability of the CISG to advanced purchase agreements (especially made with AstraZeneca) in EU Member States.
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    Heart failure with non-reduced ejection fraction: Epidemiology, pathophysiology, phenotypes, diagnosis and treatment approaches
    (2022) Cavusoglu, Yuksel; Celik, Ahmet; Altay, Hakan; Nalban, Sanem; Ozden, Ozge; Temizhan, Ahmet; Ural, Ditek; Unlu, Serkan; Yilmaz, Mehmet Birhan; Zoghi, Mehdi; 35969235
    Heart failure (HF) has been classified as reduced ejection fraction (HFrEF), mildly reduced ejection fraction (HFmrEF) and preserved ejection fraction (HFpEF) by the recent HF guidelines. In addition, HF with improved ejection fraction has been defined as a subgroup of HFrEF. In HFrEF, diagnostic workup and evidence-based pharmacological and device-based therapies have been well established. However, HFpEF, which comprises almost half of the HF population, represents significant uncertainties regarding its pathophysiology, clinical phenotypes, diagnosis and treatment. Diagnostic criteria of HFpEF have been changed a few times over the years and still remained a matter of debate. New paradigms including a prominent role of co-morbidities. inflammation, endothelial dysfunction have been proposed in its pathophysiology. As a complex, multifactorial syndrome HFpEF consists of many overlapping clinical and hemodynamic phenotypes. In contrast to HFrEF, clinical outcomes of HFpEF have not improved over the last decades due to lack of proven effective therapies. Although HFrEF and HFpEF have different clinical spectrums and proposed pathophysiological mechanisms, there is no clear defining syndrome postulated for HFmrEF. Clinical characteristics and risk factors of HFmrEF overlap with HFrEF and HFpEF. HFmrEF is also referred as a transitional zone for dynamic temporal changes in EF. So. HFpEF and HFmrEF, both namely HF with non-reduced ejection fraction (HF-NEF), have some challenges in the management of HF. The purpose of this paper is to provide a comprehensive review including epidemiology, pathophysiology, clinical presentation and phenotypes of HF-NEF and to guide clinicians for the diagnosis and therapeutic approaches based on the available data in the literature.
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    Twenty-Five Years Later, Change, Adaptation to Change and Resistance in the Dortdivan
    (2022) Gunaydin, Janset
    Bu cozumleme arayislari, belirli sosyal olgular cevresinde gerceklestirilir. Bu olgulardan linin kirilma noktalarina, ortak ve farkli degerlerinin kavranabilmesine ve bu kanitlardan yola cikarak o toplumun sosyal gelisimine katki saglayabilecek neticelerin alinmasina yardimci olur. Toplumsal ilerlemenin faydasina olabilecek cabalar, cogunlukca kabul gordugu bicimi ile insanin biraktigi izlerin dikkatle surulmesi, yorumlanmasi ve imlerde zamanla olusan degisikliklerin tespit edilmesi ile olusabilir. Yirmi Bes Yil Sonra Dortdilismasi isimli kitap ise bu baglamda ornek olacak nitelige sahiptir. Tulay Uguzman tarafindan yazilmis eser, sinirli bir toplumsal grubun somut ve soyut olarak; kulturde, fikirde, egitimde, cografyada, biraktigi izlerin degisimini inceleyen bir devam calismasi niteligindedir. 1989-1990 yillarinda yine bolgesel sinirli bir grup uzerinde ayni yazar tarafindan tirmasi adli saha calismasinin uzerinden yirmi bes yil gectikten sonra yeniden, yerinde ve detayli bir sekilde incelenmesini iceren kitap; ozgun saha calismalarina ev sahipligi yapan, sosyoloji, sosyal antropoloji ve halk kulturu icin esine az rastlanir bicimde degerli ve sosyal degisme baglaminda kaynak olabilecek niteliktedir. Incelemesi yapilan eserde calisilma suresince izlenen yontem ve tekniklerin siradanliktan uzak olusu eserdeki motiflerin de ayni cizgide ilerlemesini saglamistir. Bir toplumsal gozlemleme butununun yaziya aktarimi biciminde ozetlenebilecek bu calisma, esdeger olarak degisen cesitli yonleri tespit etmek uzere olusturulmustur. mede bir durak noktasi olan kasabanin kulturel ve sosyal yonlerinin incelenmesine odaklanan calisma, 2015'li yillara gelindiginde artik ilce konumunda olan bolgenin, yerel yonetimindeki degisim ile birlikte ic dinamiklerinde de yasanmis olmasi ongorulen farklilasmalara deginmek amaciyla olusturulan, yeniden ziyaret calismasi (revisit)1 eksenli bir yaklasimi icermektedir. Ayrica ikinci calisma icin kasabadan ilceye gecisin bir sonucu
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    The Blockade of the Dardanelles Strait and the Occupation of Bozcaada During the Tripoli and Balkan Wars, Through the Eyes of Telegrapher Ihsan (Pere) Bey
    (2022) Ozcan, Halil
    Tripoli and Balkan Wars accelerated the process leading to the collapse of the Ottoman Empire. In these wars, the Dardanelles Strait and the islands near the strait were the common target chosen by Italy and Greece for the surrender of the Ottoman Empire. In both wars, Ihsan (Pere) Bey served as the telegraph officer of the British Eastern Cable Company in Bozcaada. The Tripoli War was continuing when Ihsan Bey, who had started his civil service as an officer of the Istanbul Beyoglu British Cable Company, was appointed as officer to Bozcaada for the second time. Ihsan Bey's witnessing in Bozcaada to the hot war of the Italian Navy and the Turkish Redoubts on April 18, 1912 and the detailed information he has given are important. In addition, the occupation of Bozcaada by Greece during the Balkan War is also included in detail in Ihsan Bey's memoirs. The originality of this study results from the fact that Ihsan Bey's memoirs when Italians reached to the entrance of the Dardanelles and regarding the occupation of Bozcaada are evaluated scientifically and published for the first time.
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    Evaluation of performance levels of students for moodle learning management system in terms of usability Criteria with PSI-Entropy-Marcos integration
    (2022) Yorulmaz, Muhammet; Can, Gulin Feryal
    The study, it is aimed to determine and compare the end-user performances within the scope of achieving the determined objectives while using the Moodle Learning Management System (LMS). Accordingly, considering multiple usability criteria, 18 users were prioritized in terms of their performances in using Moodie LMS. In this direction, Preference Selection Index (PSI) and Entropy integration was used to determine the importance weights of usability criteria, and the Measurement of Alternatives and Ranking according to Compromise Solution (MARCOS) method was used to prioritize the end-users. A new hybrid weighting method has been proposed by integrating the PSI method with the Entropy method, taking into account both the uncertainty in the performance values of the end-users according to the criteria and the preference change values of the criteria. This proposed method is applied for a three-dimensional initial decision matrix Thus, the traditional two-dimensional initial decision matrix which consists of the alternatives and the values that the alternatives take according to the criteria, has been developed and made more flexible. The objective criteria taken into account in the analysis were measured by the Morae V3 program, with the tasks defined as predetermined goals being performed by the users on the Moodie LMS. In addition, the criteria weights obtained from the proposed PSI-Entropy integration were used in the MARCOS method to rank the end-users according to their performance levels.
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    Clinical approach to the child with seizure
    (2021) Saygi, Semra
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    Turkish Cardiology Association Archive
    (2021) Altay, Hakan
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    Effect of Inhaled Corticosteroid Treatment on Body Composition Parameters in Children with Asthma
    (2021) Koksal, Burcu Tahire; Yilmaz Ozbek, Ozlem
    Objective: Prolonged treatment with low doses of inhaled corticosteroids may affect the growth rate; however, limited data are currently available for body composition parameters in children with asthma. We examined whether treatment with inhaled corticosteroids has an effect on body mass index, basal metabolic rate, percentage body fat, obesity degree, fat mass, and muscle mass in children with mild asthma. Materials and Methods: The study was performed in 45 children with mild persistent asthma being treated with inhaled corticosteroids and 45 healthy controls. Body composition parameters; body mass index, percentage body fat, obesity degree, basal metabolic rate, body fat mass, muscle mass, and waist-hip circumferences were measured. Written questionnaires including duration of television/computer viewing, frequency of fast food consumption, and weekly physical activity were completed. Results: There was no difference in body composition parameters and waist-hip circumference measurements between the groups. A positive correlation was demonstrated between the duration of inhaled corticosteroid treatment and the percentage of body fat, muscle mass, fat mass, and hip circumference. When compared with healthy controls, a significant increase in the duration of television/ computer viewing and frequency of fast food consumption and a significant decrease in weekly physical activity were observed in children with asthma. Conclusion: Body composition parameters seem not to be affected in the inhaled steroid-using children with asthma. However, as the duration of inhaled corticosteroid treatment increased, the percentage of body fat, body fat mass, and hip circumference also increased. Children with asthma should be encouraged to increase physical activity and be recommended to decrease the duration of television/computer viewing.