Wos İndeksli Açık & Kapalı Erişimli Yayınlar
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Item How hematopoietic stem cell transplantation activity was affected during the pandemic? JACIE accredited center reflex(2022) Kozanoglu, I.; Tepebasi, S.; Kursun, E.; Sen, N.; Unsal, Z. E.; Kis, C.; Boga, C.; Yesilagac, H.; Demiroglu, Y. Z.; Pocan, G.Item TBI/fludarabine versus busulfan/fludarabine as a myeloablative conditioning for adults with acute myeloid leukemia treated with allo-HCT. A study from the ALWP of the EBMT(2022) Swoboda, R.; Labopin, M.; Giebel, S.; Schroeder, T.; Kroeger, N.; Arat, M.; Savani, B.; Spyridonidis, A.; Hamladji, R. M.; Potter, V.; Deconinck, E.; Yakoub-Agha, I.; Rambaldi, A.; Ozdogu, H.; Sanz, J.; Nagler, A.; Mohty, M.Item Traveling Repairmen Problem: A Biogeography-Based Optimization(2022) Uzun, Gozde Onder; Dengiz, Berna; Kara, Imdat; Karasan, Oya EkinTraveling Repairman Problem (TRP), which is also known by names cumulative traveling salesman problem, the deliveryman problem and the minimum latency problem, is a special variant of Traveling Salesman Problem (TSP). In contrast to the minimization of completion time objective of TSP, the desired objective of TRP is to minimize the cumulative latency (waiting time or delay time) of all customers. In this paper, a generalized version of TRP with multi depots and time windows, namely Multi Depot Traveling Repairman Problem with Time Windows (MDTRPTW) is considered. A group of homogeneous repairmen initiate and finish their visit tours at multiple depots. Each customer must be visited exactly by one repairman within their provided earliest end latest times. Being a challenging Nondeterministic Polynomial-hard (NP-hard) optimization problem, exact solution approaches are not expected to scale to realistic dimensions of MDTRPTW. Thus, we propose a biogeography-based optimization algorithm (BBOA) as a metaheuristic approach to solve large size MDTRPTW problems. The proposed metaheuristic is analyzed in terms of solution quality, coefficient of variation as well as computation time by solving some test problems adapted from the related literature. The efficacy of the proposed solution methodology is demonstrated by solving instances with 288 customers within seconds.Item A diffusion tensor imaging study in schizophrenia patients with clozapine induced obsessive compulsive symptoms(2023) Ay, Sule Bicakci; Oguz, Kader K.; Eroglu, Elcin Ozcelik; Has, Arzu Ceylan; Ertugrul, Aygun; 36382404Objective The aim of this study was to evaluate brain connectivity by diffusion tensor imaging (DTI) in schizophrenia patients with clozapine-induced obsessive compulsive symptoms (OCS). Methods Eighteen schizophrenia patients, nine of which had clozapine-induced OCS (Clz-OCS (+)), 9 without OCS (Clz-OCS (-)) and 9 healthy controls were included. Psychopathology was evaluated with Positive and Negative Syndrome Scale and Yale-Brown Obsession and Compulsion Scale in the patient groups. All groups were assesed with neurocognitive tests and DTI. Results Tract-Based Spatial Statistics based comparison of DTI revealed lower fractional anisotropy in the genu of corpus callosum (CC), right cingulum, left frontal white matter (WM) in the Clz-OCS (+) group, compared to controls. Fractional anisotropy was found to be lower in the bilateral occipital WM and higher in the bilateral medial temporal regions, anterior limb of internal capsule, cingulum, frontoparietal peripheral WM, right external capsule and genu of CC in Clz-OCS (+) patients compared to Clz-OCS (-). Conclusions WM integrity in several pathways such as cortico-striato-thalamo-cortical circuitry and orbito-frontal tracts seems to be affected differently in patients with Clz-OCS (+). Different neuroplastic effects of clozapine leading to occurrence of OCS in a subgroup of patients is possible, and needs further evaluation by longitudinal follow-up studies.Item The Inventory of Flood Disasters in Turkey(2022) Gurer, Ibrahim; Ucar, IbrahimTurkey is located both Europe and Asia, and covers an area of 780 580 km(2) including the lakes. Turkey undergoes different types of natural disasters because of its geographical location, geomorphology, and topography. Flooding is the second important natural hazard after earthquakes. A flood inventory of the period extending from 1955 to 2020 having a total of about 3250 events was prepared using a simple computer program based on Excel for easy access to different geomorphologic parameters such as surface areas of river basins, slope, geological structure, vegetative cover, type of precipitation, and the elevation above mean sea level (a.m.s.l) and hydro-meteorological parameters. In the same inventory each flood has been defined with damages on human as lost and injured, size of flooded area and loss of wealth (not exact information for wealth). By categorization of the available data in hand, spatial and time distributions of past flood events were determined. In large basins, negative impacts are more closely related to climatic factors, but in small watersheds, the urbanization along the rivers, internal migration, regional planning, urban drainage infrastructure are more important on negative impacts. In order to prevent the floods and minimize the adverse effects to property, both structural and non-structural solutions are applied in Turkey. Two case studies added to show the solutions.Item Hydropower Outlook of Turkey in 2021(2022) Gurer, IbrahimTurkey is located partly on Europe and also on Asia, and has a surface area of 780 580 km(2) and a population of 84.6 million and electric energy is essential for the everyday life. The annual per capita consumption of electricity is mainly used to measure the prosperity of a nation. The energy use in a country increases not only with population increase but also by improving the living standards of people and industrial development. Turkey being a non-oil-producing country at present, therefore needs to import fossil fuels (like natural gas and fuel oil) as the main source of electric energy. The utilization of fossil fuels for energy production by thermal power plants is one of the main sources of air pollution. The consumption of imported energy sources should be reduced for the environmental, economic, and political reasons. As the electricity need of the country is increasing continuously, more energy from the renewables and national resources must be produced. Hydropower plants (HPPs) provide clean, fast, flexible electricity generation. The amount of electricity that aHPP can produce basically depends on the available flow rate (Q) and the head (H). Very briefly the greater the flow rate and the net head, the more electricity can be produced in a HPP. The first hydropower station of Turkey had been opened at Tarsus town in 1929. Number of hydropower installations and total installed capacity has increased especially after the 1960s. In 2020, the Turkish electric production values were 32.9% from HPPs, 27.2% from thermal plants working with natural gas, 21.3% from thermal plants working with coal, 8.8% fromwind power plants, 6.8% from the sun, 1.6% from geothermal plants, and about 1.4% from other types of sources. Technically and economically feasible total hydroelectric energy potential of Turkey is 180 billion kWh/year, of which 160 billion kWh/year has been developed and completed. With 714 completed facilities and 31,391 MW installed power and 108.0 billion kWh/year of it has been put into operation. With the projects to be established until 2023, a total installed power capacity of 40,000 MW and a generation potential of 135 billion kWh/year will be reached. Because of the very fast increase in energy consumption, and only 22% of total energy is produced from national sources, and 125 billion dollars total investment is needed. Due to the climate change, and the change in the oil prices, the renewable sources such as solar, wind, geothermal, biogas, biomass, hydropower etc. should be developed and put in service as quickly and efficiently as possible. In this paper, the current level of hydropower production and energy saving, and power consumption by different sectors, and the subject matter of the most recent energy figures are given and the future projections are also presented.Item Turkish validity and reliability of the Cancer Stigma Scale (CASS-T)(2023) Cevik, Banu; Kav, Sultan; Kaynar, Pelinsu; Sahin, Zeynep Kubra; Tekcan, Busra; Ulker, Seymanur; 0000-0003-1396-854X; 35699122Objectives This study is aimed to evaluate the validity and reliability of the Cancer Stigma Scale for the Turkish population (CASS-T). Methods The sample of the study consisted of 412 students of a foundation university located in Ankara, Turkey. The reliability of the CASS was evaluated using the Cronbach alpha reliability coefficient and item-total score correlations. Exploratory factor analyses were applied to examine the factor structure of the scale and its construct validity. To test the time invariance of the scale, the relationships between the scores obtained from the first and second applications were examined using the intraclass correlation coefficient (ICC). Results The Cronbach's alpha coefficient of CASS-T was 0.83. In the factor analysis, it was confirmed that the scale has a six-dimensional structure in parallel to original version, namely Avoidance, Severity, Responsibility, Policy opposition, Awkwardness, and Discrimination. The ICC values all remained in the range that indicates the reliability of the 0.63-0.71 to be substantial. The contribution of the six factors of the CASS-T scale to the variance is 57.8. Significance in results The Turkish version of the CASS was confirmed to have good reliability and validity for evaluating stigma toward cancer in Turkish society.Item Validity and Reliability Evidence of Professional Obsolescence Scale According to Different Test Theories(2021) Altun, Sedagul Akbaba; Buyukorturk, Sener; Seheryeli, Merve YildirimThis study aims to develop a scale that will determine the factors causing professional obsolescence in the field of education. In this context, the Professional Obsolescence Scale (POS) has been developed to determine the professional and organizational obsolescence of primary, secondary and high school administrators. In this scale development process, steps were followed in line with the suggestions of Crocker and Algina (2006) and Cronbach (1984). Firstly, 63 items were prepared and 991 school principals participated the study. R (version 4.0.1) software was used to analyze the data. Item and test parameters and information functions have been estimated using Samejima's Graded Response Model based on Item Response Theory. Principal Axis Analysis was performed for the construct validity of the scale, and four-dimensions structure with 47 items has been obtained. These dimensions are named as "Being Open to Professional Development", "Job-Ability Harmony in Profession", "Organizational Support in Professional Development", "Professional Burnout". The scores obtained from each dimension are evaluated within themselves. It has been observed that each dimension fulfills the conditions of unidimensionality, local independence, model-data fit and parameter invariance. According to the Classical Test Theory, Cronbach Alpha coefficients are between 0.807 and 0.945. The Stratified Alpha coefficient calculated for the whole scale is 0.94. According to the Item Response Theory, the marginal reliability coefficients were between 0.857 and 0.936 and the empirical reliability coefficients were found between 0.854 and 0.938.Item Early Maxillary Expansion with the Ni-Ti Memory Leaf Expander-A Compliance-Free Fixed Slow Maxillary Expansion Screw: A Report of 2 Cases(2021) Ulug, Bahar; Ozcirpici, Ayca Arman; 35110164Transversal problems such as crowding and crossbite are one of the most common problems dealt with in early orthodontic treatments. Early correction of these problems may ease or even eliminate the future need for treatment. This paper presents the management of 2 cases with transverse discrepancy using the Ni-Ti Memory Leaf Expander-a new compliance-free slow maxillary expansion appliance. The total treatment time for both cases was 9 months. In both cases, the inter-canine, inter-premolar, and inter-molar distances, as well as the arch length, have all increased.Item Feasibility of Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Ovarian Cancer During COVID-19 Pandemic(2021) Ayhan, Ali; Yilmaz Baran, Safak; Vatansever, Dogan; Dogan Durdag, Gulsen; Celik, Husnu; Taskiran, Cagatay; Akilli, Huseyin; 0000-0001-5874-7324; 0000-0002-5240-8441; 33858953; AAX-3230-2020Objective This study aims to evaluate the effect of the COVID-19 pandemic and related restrictions on patients who underwent cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) for ovarian cancer. Methods We retrospectively evaluated ovarian cancer patients who underwent HIPEC following complete cytoreductive surgery performed during the outbreak of the COVID-19 pandemic in three different centers specializing in gynecological oncology. All patients who underwent cytoreduction plus HIPEC for a primary, interval, and recurrent surgery were evaluated. Primary outcomes was postoperative 30-day morbidity and mortality. The secondary outcome was infection of patient and/or related staff with COVID-19 during the perioperative or early postoperative period. Results We performed a total of 35 HIPEC procedures during the pandemic: 15 (42.9%) patients underwent primary/interval surgery, while 20 (57.1%) patients had recurrent disease. Grade 3-4 complications occurred in one patient (2.9%) (chronic renal failure), while mortality did not occur in any patient. Neither the patients nor related staff were infected with the coronavirus during the perioperative or early postoperative period. One patient, who was diagnosed with COVID-19 pneumonia on postoperative day 80 died from the infection. Another patient died on postoperative day 85 due to progressive ovarian cancer, a disorder in vital functions, and organ failure. Conclusion HIPEC during the COVID-19 pandemic seems a safe and feasible procedure, with acceptable morbidity and mortality rates. Careful selection of patients is important and precautions should be taken before the procedure.
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