Wos İndeksli Açık & Kapalı Erişimli Yayınlar

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Author: search.filters.author.Emre, Sinansearch.filters.applied.f.language: search.filters.language.eng

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    Optical Coherence Tomography Angiography (OCTA) In Differential Diagnosis Of Aquaporin-4 Antibody Seronegative NMOSD And Multiple Sclerosis
    (2022) Tiftikcioglu, Bedile Irem; Emre, Sinan; Idiman, Fethi; Idiman, Egemen; 35030370
    Backround: Optic neuritis(ON) is a common feature of both relapsing-remitting multiple sclerosis(RRMS) and neuromyelitis optica spectrum disorders(NMOSD). It is crucial to early differentiate these two diseases, as they differ in pathophysiology and treatment.& nbsp;Objective: To compare NMOSD and RRMS patients using optical coherence tomography(OCT) and OCT angiography(OCTA) to assess retinal microvascular network differences.& nbsp;Methods: Fourteen RRMS (28 eyes) and 9 NMOSD patients(18 eyes), and 11 controls were enrolled. Seropositivity for aquaporin-4 antibody (anti-AQP4 Abs) was 44.4%. Peripapillary and macular retinal nerve fiber layer (RNFL) thickness, superficial peripapillary and macular vessel density(VD), area, perimeter and circularity of foveal avascular zone(FAZ) were analyzed.& nbsp;Results: OCTA showed reduction in peripapillary and macular VD and FAZ size in NMOSD+ON compared to RRMS+ON and controls (p = 0.001, p < 0.001 and p = 0.010, p < 0.001 respectively). Peripapillary VD was similar in RRMS +ON and controls. Peripapillary VD in monophasic seronegative NMOSD+ON eyes was significantly lower than monophasic RRMS+ON eyes (p = 0.030), which was no different from controls. FAZ area was smaller in unaffected eyes in NMOSD than RRMS and controls.& nbsp;Conclusions: Both OCT and OCTA revealed considerable differences between RRMS and NMOSD patients, providing promising results in favor of clinical utility of OCTA in differential diagnosis of ON, particularly in antiAQP4 antibody negative patients. OCTA might be a useful biomarker in differentiating NMOSD from MS.
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    Importance of Optical Coherence Tomography Angiography in Differential Diagnosis of NMOSD and RRMS
    (2019) Tiftikcioglu, B. Irem; Emre, Sinan; Idiman, Fethi; Idiman, Egemen
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    Optical coherence tomography angiography findings in Behcet patients
    (2019) Emre, Sinan; Guven-Yilmaz, Suzan; Ulusoy, Mahmut Oguz; Ates, Halil; 30710254
    PurposeRetinal vasculitis and vein occlusions are common causes of serious visual loss in Behcet's disease. We aimed to evaluate the optical coherence tomography angiography (OCTA) findings of Behcet uveitis (BU) patients.MethodsWe evaluated 32 eyes of 16 patients with BU and 30 eyes of 15 healthy controls. Superficial capillary plexus (SCP) and deeper capillary plexuses (DCP) were evaluated using OCTA RTVue XR AVANTI.ResultsOn SCP, nonperfusion/hypoperfusion areas (NPA) were seen in 10 eyes, perifoveal capillary arcade disruption (PCAD) was seen in 10 eyes, capillary network disorganization (CND) was seen in 7 eyes and intraretinal cystoid spaces (ICS) were seen in 2 eyes. On DCP, NPA were seen in 13 eyes, PCAD was seen in 11 eyes, CND was seen in 7 eyes and ICS were seen in 4 eyes.ConclusionWe showed that DCP were affected more than SCP in these patients. In addition, capillary vessel density of BU group was significantly lower than control group.
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    Evaluation of the acute effect of haemodialysis on retina and optic nerve with optical coherence tomography
    (2016) Emre, Sinan; Ozturkeri, Anil; Ulusoy, Mahmut Oguz; Cankurtaran, Cem; 28003781; T-5643-2019
    Purpose: The primary objective of haemodialysis (HD) was to correct the composition and volume of body fluids. The aim of this study was to evaluate the acute effect of HD on mean arterial pressure changes and on retina and optic nerve with optical coherence tomography (OCT). Methods: Fifty-three eyes of 28 patients were enrolled in this study. The patients' retinal and RNFL thicknesses were measured by OCT and mean arterial pressure alterations were recorded before and immediately after HD session. Results: The results show that while there was a reduction at central foveal thickness and ganglion cell layer thickness, central sub-field and RNFL thickness were increased with HD session. But none of them were statistically significant (p = 0.320, p = 0.792, p = 0.744, p = 0.390). The mean arterial pressure of the patients decreased significantly (p < 0.05) but it was not correlated with retinal and RNFL values. Conclusion: The changes in retinal and RNFL findings were not significant. But these alterations may effect the long term follow-up of the patients with retinal and optic nerve disease. Therefore it is important to pay attention HD session time for these patients' measurements.
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    Are optic discs with large physiological cups really healthy?
    (2017) Ulusoy, Mahmut Oguz; Emre, Sinan; 28254119; T-5643-2019