Scopus İndeksli Açık & Kapalı Erişimli Yayınlar
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Item Effect of Pulmonary Functions on Survival in Patients with Operable Non-small Cell Lung Cancer(2022) Cihanbeylerden, Melek; Yumrukuz, Merve; Kurt, Bahar; Tuccar, Cise; Safak, Cagla; 35546696Objective: To investigate the prognostic importance of pulmonary functions and their effect on survival in patients with operable non-small cell lung cancer (NSCLC), who underwent surgical resection and/or received medical treatment. Study Design: Cohort study. Study Design: Cohort study. Place and Duration of Study: University of Health Sciences, Diskapi Training and Research Hospital, Ankara, Turkey, between June 2013 and March 2020. Methodology: The study included a total of 70 patients diagnosed with non-small cell lung cancer (NSCLC), comprising 35 who underwent surgical treatment and 35 who were treated medically. The effects of age, gender, additional comorbidities, smoking status, complications after surgery and/or radiotherapy, and pulmonary function test values on survival were investigated. Results: The median overall survival time of the patients was 1973 +/- 769.1 (466-3.480) days. According to the univariate Cox regression analysis, the preoperative and postoperative values of the forced expiratory volume in 1 second were not important risk factors affecting survival (p=0.752 and p=0.878) respectively. A statistically significant difference was observed in survival probability between the patients with and without coronary artery disease (CAD) (p=0.005). There was also a statistically significant difference between the Eastern Cooperative Oncology Group (ECOG) performance groups in terms of survival probability (p<0.001). Conclusion: There was no relationship between pulmonary functions and survival in patients with operable NSCLC, but this evaluation should be undertaken in larger patient groups. This study demonstrated the importance of patients' performance status and comorbidities, such as CAD in survival.Item Improving Survival Besides the High Early Mortality Rate in Acute Promyelocytic Leukemia(2022) Malkan, Umit Yavuz; Koca, Ebru; Buyukasik, YahyaThe improvement in survivals of acute promyelocytic leukemia (APL) patients are still debated. In this study, we aimed to analyze the survival and early mortality (EM) rates of APL patients. In this study, de-novo APL patients who was followed up by our clinic between the years 2003-2021, were retrospectively analyzed. Patients were divided in according to their year of diagnosis, 2003-2013 (n= 33) and 2014-2021 (n= 19) groups. The 2-years survival is 52.5% and 78.9% in 2003-2013 group and 2014-2021 group, respectively, p= 0.069.The EM was not statistically different between the 2003-2013 and 2014-2021 groups (11/22 vs.4/15, p= 0.347). The 2-years survival ratio is 75.3% and 36.4% in modified-AIDA and IDA-ARA/C-ATRA treatment groups, respectively, p= 0.003. EM according to treatment groups were 7/38 versus 7/11 in modified-AIDA and IDA-ARA/C-ATRA,respectively, p= 0.001.White blood cell count >= 10000/mu l is the most important predictor of EM with overall prediction of 79.5%. The second most important factor which is related with EM is infection of patients at presentation.If these two factors are considered together there is an 84.1% overall prediction of EM. The third and last significant factors that effects EM is the induction treatment protocol. If these three significant parameters considered all together,there would be an 88.6% overall prediction of EM. The overall survival of APL patients is slightly improved between the years 2014-2021 compared to 2003-2013. The reason of this improvement is not the reduction of EM in the APL patients. Better diagnostic tools and molecular monitoring and better supportive care may have played role in the improvement of the survival of APL patients. In order to further improvement of the overall survival of APL patients, EM rates must be decreased. According to our study results, rapid and efficient treatment of infections in APL patients look like the only modifiable parameter that is related with EM.Item Survival impact of number of removed para-aortic lymph nodes in stage I epithelial ovarian cancer(2021) Gunakan, Emre; Akilli, Huseyin; Kara, Atacan Timucin; Altundag, Ozden; Haberal, Asuman Nihan; Meydanli, Mehmet Mutlu; Ayhan, Ali; 0000-0002-5240-8441; 0000-0003-0197-6622; 0000-0001-8854-8190; 34410474; AAX-3230-2020; W-9219-2019; ABI-1707-2020Purpose The survival effect of presence or absence of lymphadenectomy in early-stage epithelial ovarian cancer (EOC) was priorly shown but the effect of number of removed lymph nodes kept in background. We aimed to evaluate the survival impact of number of removed lymph nodes and their localizations in stage I EOC. Methods This study included 182 patients. The best cut-off levels for number of pelvic and para-aortic lymph nodes (PaLN) were 24 and 10, respectively. Univariate and multivariate survival analyses were performed for these cut-offs and other prognostic factors. Results The median age of the patients was 49. The median number of removed pelvic and paraartic lymph nodes were 29 and 9, respectively. The median overall (OS) and progression-free survival (PFS) were 67 and 50 months, respectively. The 5-year OS rate was 89.6%. Recurrence occured in 24 (19.5%) patients. In univariate analyses tumor grade (p: 0.005), pelvic LN number (p: 0.041) and PaLN number (p: 0.004) were the factors that were significantly associated with PFS. Tumor grade and PaLN number were independently and significantly associated with PFS in multivariate analyses (p: 0.015 and p: 0.017, respectively). In OS analyses, age, tumor grade, presence of LVI, number of pelvic and PaLNs were the significantly associated factors (p < 0.05 for all). In multivariate analyses, age and PaLN number were independently and significantly associated with OS (p: 0.011 and p: 0.021, respectively). Conclusions The number and localizations of removed lymph nodes may have a survival affect in stage I EOC. We also think that this study may constitute a kernel point for larger prospective series on lymph node number and lymphatic regions.Item Metaplastic Carcinoma of the Breast: Analysis of 38 Cases from a Single Institute(2020) Hasbay, Bermal; Aka Bolat, Filiz; Aytac, Huseyin Ozgur; Aslan, Hulya; Purbager, Aysin; 0000-0002-7138-246X; 0000-0002-3583-9282; 31769499; AAK-9104-2021; AAJ-7913-2021Objective: To evaluate the pathological and radiological features, hormone profiles, surgery and treatment methods of metaplastic breast carcinoma cases diagnosed at our center in the light of current literature. Material and Method: A total of 38 metaplastic breast cancer cases diagnosed between 2006-2018 at our center were included in the study. The patients were evaluated in terms of age, tumor size, localization, histological grade, hormone profiles (ER, PR, Her2-neu), American Joint Committee on Cancer (AJCC) Tumor, Lymph node status, Metastases (TNM) stage, progression, survival, radiological features, types of surgery and therapy modalities (chemotherapy and / or radiotherapy). Results: The age of the patients ranged between 32 and 95 years. Pathological evaluation of cases showed that 14 were pure epithelial (IC-NST + squamous cell carcinoma) and 24 were metaplastic carcinomas with mesenchymal differentiation. Ductal carcinoma in situ (DCIS) was accompanying an invasive component in twenty cases. Seventeen patients had lymph node metastasis. Twelve patients developed distant metastasis. Thirty patients were triple negative for hormone receptors. The mean follow-up period of the patients was 34 months. The estimated life expectancy was 116 months. All of the patients received chemotherapy and 28 patients received adjuvant radiotherapy. There was no correlation between tumor size and lymph node or distant metastasis in our series. Our findings are consistent with the literature. Conclusion: Metaplastic breast carcinoma is a rare entity among breast carcinomas. Metaplastic carcinomas of the breast draw attention with the differences in their clinical course and the radiological and pathological heterogeneity.