Scopus İndeksli Açık & Kapalı Erişimli Yayınlar
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Item The Role of Nutritional and Dietary Habits in Etiology in Pediatric Vocal Fold Nodule(2022) Korkmaz, Muge Ozcelik; Tuzuner, ArzuObjectives. In pediatric pediatric vocal fold nodule (VFN) patients, different causes have been suggested in the development of the vocal cord nodule, including laryngopharyngeal reflux (LPR). It is known that the content of consumed foods, obesity, and other dietary behaviors are among the risk factors for the devel-opment of reflux. The aim of this study was to evaluate dietary and food consumption habits in pediatric VFN patients.Methods. This prospective-controlled study included 50 children with VFNs (age range 5-14 years) and 50 age-matched children without any voice disorders as a control group. BMI values of each participant were evaluated according to age-percentile range. The voice usage habits and personality structure of all the children were ques-tioned. All patients underwent laryngeal examination and voice analysis. The Turkish Pediatric Voice Handicap Index (t-PVHI) and Child Voice Handicap Index-10 (t-CVHI) were completed by patients or their parents. The examination findings of all patients were evaluated with the reflux finding score (RFS), and their complaints were questioned with the reflux symptom index (RSI). In addition, eating and drinking at night, fast eating and exces -sive food consumption habits and the frequency of consumption of packaged foods defined as junk food, carbon-ated beverage were questioned. The data obtained were compared statistically between the two groups.Results. There was no significant difference between the study and control groups in terms of age, gender distri-bution, median BMI value, voice usage habits, and personality structure. In the study group, t-PVHI, t-CVHI, jit-ter, schimmer values, the mean RFS, and RSI scores were significantly higher than those of the control group. The number of children with high consumption of junk food and carbonated drinks was higher in the study group. There was no significant difference between the two groups in terms of dietary habits.Conclusion. Food consumption habits may play a role in childhood voice problems in this population.Item A Highly Potent SARS-CoV-2 Blocking Lectin Protein(2022) Ahan, Recep E.; Hanifehnezhad, Alireza; Kehribar, Ebru S.; Oguzoglu, Tuba C.; Foldes, Katalin; Ozcelik, Cemile E.; Filazi, Nazlican; Oztop, Sidika; Palaz, Fahreddin; Onder, Sevgen; Bozkurt, Eray U.; Ergunay, Koray; Ozkul, Aykut; Seker, Urartu Ozgur Safak; https://orcid.org/0000-0001-5653-6080; 35426678; AAJ-7911-2020The COVID-19 (coronavirus disease-19) pandemic affected more than 180 million people around the globe, causing more than five million deaths as of January 2022. SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), the new coronavirus, has been identified as the primary cause of the infection. The number of vaccinated people is increasing; however, prophylactic drugs are highly demanded to ensure secure social contact. A number of drug molecules have been repurposed to fight against SARS-CoV-2, and some of them have been proven to be effective in preventing hospitalization or ICU admissions. Here, we demonstrated griffithsin (GRFT), a lectin protein, to block the entry of SARS-CoV-2 and its variants, Delta and Omicron, into the Vero E6 cell lines and IFNAR(-/-) mouse models by attaching to the spike protein of SARS-CoV-2. Given the current mutation frequency of SARS-CoV-2, we believe that GRFT protein-based drugs will have a high impact in preventing the transmission of both the Wuhan strain as well as any other emerging variants, including Delta and Omicron variants, causing the high-speed spread of COVID-19.Item Insights on Lipomatosis after Platinum-Based Chemotherapy Use in Pediatric Oncology: A Case Report(2022) Boeriu, Estera; Boc, Alexandra Georgiana; Borda, Alexandra; Negrean, Rodica Anamaria; Feciche, Bogdan; Boeriu, Amalia Iulia; Horhat, Florin George; Mot, Ion Cristian; Horhat, Ioana Delia; Ravulapalli, Madhavi; Sabuni, Omar; Adi, Abduljabar; Anjary, Adnan; Arghirescu, Smaranda Teodora; 0000-0002-6147-6518; 36556917Agents of platinum-based chemotherapy, such as cisplatin or carboplatin, are used in the treatment of a wide range of malignancies that affect children, such as brain tumors, osteosarcoma, neuroblastoma, hepatoblastoma, and germ cell tumors (GCTs). The Cyclophosphamide Equivalent Dose (CED) calculator for reproductive risk does not take platinum-based chemotherapy into account, despite the fact that it accounts for the majority of chemotherapy medications that are typically administered for pediatric GCTs. As a result, exposure to platinum-based drugs throughout infancy can have predictable long-term effects such as infertility, as well as other rare encounters such as lipoma formation and lipomatosis. Lipomas are the most prevalent benign soft tissue tumor subtype. They may be either solitary entities or engaged in multiple lipomatosis, which may have a familial origin or be an acquired disorder. Chemotherapy is a possible cause of lipomatosis. Chemotherapy based on cisplatin has been linked to a variety of long-term consequences, including kidney damage, neurotoxicity, and pulmonary toxicity, and may even create secondary cancers. However, lipoma development is known to occur in fewer than 1 in 100 individuals, and only a few examples of multiple cutaneous lipomatosis triggered by this therapy have been documented. Here we present a very rare case of lipomatosis in a pediatric patient with GCT under cisplatin therapy, which might be the third report of this kind affecting children.Item Who Desires To Stay? The Role Of Relational Job Crafting On The Intention To Stay With The Mediating Role Of Workplace Friendship(2022) Cinar, Esra; Basim, H. NejatDrawing on theory of reasoned action and identity theory, we examined the mediating effect of workplace friendship on the association between relational job crafting and the intention to stay. The hypotheses were tested by analysing the data collected from 228 participants. We found positive and significant relationships between the intention to stay and relational job crafting, as well as with workplace friendship. Furthermore, a positive and significant relationship between relational job crafting and workplace friendship was found. The results also indicate that workplace friendship has a partial mediating effect on the relationship between relational job crafting and the intention to stay.Item Comparison Of Clinical Characteristics Of Second And Third Peaks Of COVID-19 Pandemic: Effects Of Vaccination And Preventive Measures(2022) Ozdemir, Ozer; Arslan, Atakan; Bulbul, Hande M.; Ozdemir, PelinBACKGROUND: Understanding the differences in consequent peaks of COVID-19 may guide us for better predicting future disease characteristics. In this study, we aimed to compare clinical and radiological characteristics as well as out-comes of hospitalized patients with the diagnosis of COVID-19 in second and third peaks of disease.METHODS: We retrospectively included 303 hospitalized patients with COVID-19. The study population was examined in two groups: patients hospitalized between October 2020 and January 2021 during second peak and patients hospital-ized between March and June 2021 during third peak.RESULTS: There were 171 patients in group 1 and 132 patients in group 2. The patients in group 2 were younger (64 +/- 13.27 vs. 56.02 +/- 15.39, respectively; P<0.001) and female proportion was higher (64.9% and 48.5% males; P=0.005). Smoking history and presence of comorbidities were less in group 2 (41.5% vs. 25.7%, P=0.008; and 78.5% vs. 59.1%, P<0.001) and symptom duration was shorter (median 7 days vs. 6 days, P=0.039). CT severity scores, LDH, CRP, D-di-mer, Ferritin, and creatinine levels were lower in group 2 (P=0.003, P=0.008, P<0.001, P<0.001, P<0.001, respectively), and mortality ratio was lower (N.=39 [28%] vs. N.=15 [11.4%], P=0.01). Duration of hospital stay and need for intensive unit care were similar across groups (median 8 days vs. 7 days, P=0.673 and N.=39 [22.8%] vs. N.=33 [25.2%], P=0.683).CONCLUSIONS: Although duration of hospital stay was lower in third peak, clinical severity scores and prognostic markers were lower compared with second peak. These may reflect the increased proportion of immunized people, and the effect of preventive measures.Item Development of Electrochemical Biosensor Platforms for Determination of Environmental Viral Structures(2022) Ekici, Rumeysa; Bozdogan, Betul; Denkbas, Emir BakiInfectious diseases caused by viruses (such as influenza, Zika, human immunodeficiency, Ebola, dengue, hepatitis, and COVID-19 virus) are diseases that have been on the agenda of the whole world for the last quarter of a century and have become one of the most important problems for people. Urgent identification of the people infected with a disease will allow these people who have contracted the disease to be treated effectively. In this context, the polymerase-chain-reaction (PCR)-based methods have been the most common and widely used method that responds with sensitivity. However, due to some disadvantages encountered in PCR applications (in particular, the test protocol is comprehensive, not fast in terms of time, not economical, requires user expertise, is not suitable for field/on-site measurements, etc.), a new generation (which can give fast results, are economical, sensitive, suitable for on-site application, etc.) of systems that can provide solutions are needed. On the subject of different test-diagnostic applications used in a large number of test-based analysis methods and techniques, electroanalytical systems have some advantages. Within the scope of this presentation, low-cost, miniaturized electrochemical platforms for surface-printed electrodes by using appropriate biochemical and viral structures of the electrode surfaces decorated with suitable agents are explained. These platforms can be used in the determination of some particular viral proteins for the understanding of viral pathogenic diseases. In this study, a copper-modified graphite electrode was developed and characterized with SEM. Afterwards, an antibody of the N protein of COVID-19 was decorated surrounding this electrode to measure the amount of that protein in the samples. The square wave voltammetry (SWV) technique was used for the electrochemical detection of SARS-CoV-2. When the results of the analyses were examined, the best analytical sensitivity and linearity were obtained by incubating the antibody-modified electrode and virus antigen for 10 min. The measurements showed linearity with a high correlation coefficient (R-2 = 0.9917). The detection limit (LOD) was calculated as 508 pg/mL. The measurement limit (LOQ) was calculated as 1.54 ng/mL. With the pencil tip, which is an easily accessible material for the modified electrode system we designed, a very precise measurement was provided for the rapid detection of the N protein of the SARS-CoV-2 virus at very low concentrations.Item Pediatric T-cell Lymphoblastic Leukemia/Lymphoma Diagnosed at Routine Adenoidectomy Specimen(2023) Kara, Iike; Ramadan, Saime; Senkal, Evrim; Kocdor, Pelin; 36476077Postoperative routine pathologic evaluation of tonsillectomy and adenoidectomy specimens rarely reveals a diagnosis of malignancy. The object of this case report is to highlight this rare clinical occurrence. A 4-year-old boy presented with symptoms of sleep-disordered breathing and had a history of recurrent tonsillitis. Physical examination revealed adenoid hypertrophy and Brodsky Grade 1 bilateral tonsillar hypertrophy. The patient underwent adenoidectomy and tonsillectomy. The adenoids were found to be MAGS Grade 4 (Modified Adenoid Grading System) hypertrophic causing 100% obstruction. After the histologic examination, T-cell lymphoblastic leukemia/lymphoma was diagnosed. Proper treatment allowed full recovery. Currently, no consensus has been made about routine pathological evaluation. To achieve a cost-effective and precautionary approach, we recommend pathological follow-up of cases with unusual intraoperative findings with/without clinical malignancy suspicion.Item Clinical Effectiveness Of Buccally And Palatally Anchored Maxillary Molar Distalization: The Miniscrew-Supported 3-Dimensional Maxillary Bimetric Distalizing Arch Vs The Beneslider(2022) Tuncer, Nilufer Irem; Arman-Ozcirpici, Ayca; 36457217Introduction: This study aimed to investigate the dentoalveolar and skeletal changes achieved with a novel miniscrew-supported 3-dimensional maxillary bimetric distalizing arch (3D-MBDA) and the Beneslider. In addition, the study aimed to compare these changes between each other and with an untreated control group. Methods: Sixty-five patients with bilateral Class II molar relationship and fully-erupted maxillary second molars were included in the study. Of these patients, 23 received the miniscrew-supported 3D-MBDA (group 1), 21 received the Beneslider (group 2), and 21 served as untreated control subjects (group 3). Lateral cephalometric films and dental casts, taken at the beginning and the end of maxillary molar distalization, were analyzed to study the differences between the groups. Results: The crown distalization of the first molars was similar between the treatment groups (group 1, 3.1 mm; group 2, 3.3 mm); however, root distalization was significantly more in group 1 (5 mm) when compared with group 2 (1.7 mm). The first molars tipped 6.2 degrees in the mesial direction in group 1 and 8.2 degrees in the distal direction in group 2. The mesiobuccal cusp tip of the first molars extruded for 1.2 mm and increased vertical dimensions in group 2, whereas it intruded for 1.7 mm in group 1. Meanwhile, aforementioned parameters presented insignificant changes throughout the observation period in the control group. Inter-first molar width increased significantly in group 2 (2.7 mm). Distalization time was similar between the groups (group 1, 14 months; group 2, 15 months). The distalization rate was higher in group 2 (0.27 mm/mo) than in group 1 (0.23 mm/mo) measured from the crowns; however, it was similar between the groups (group 1, 0.25 mm/mo; group 2, 0.19 mm/mo) when measured from the trifurcation point. Conclusions: The miniscrew-supported 3D-MBDA was more effective in distalizing molar roots and maintaining vertical parameters and dental arch width while tipping the molars mesially. In contrast, the Beneslider distalized molar crowns faster, resulting in significant distal tipping. (Am J Orthod Dentofacial Orthop 2022;162:e337-e348)Item Letter To Editor in Regard to Recent Published Study of Abed Et Al. Titled 'The Association Between Dental Arch Length And Oral Health-Related Quality of Life in Head And Neck Cancer Patients Post-Radiotherapy'(2023) Yilmaz, Busra; Somay, Efsun; https://orcid.org/0000-0003-0633-5648; 36222114Item The Effect Of Kefir Enrichment With Arthrospira Platensis And Chlorella Vulgaris On Kefir Microbiota, Antioxidant, And Physicochemical Properties(2022) Kahraman Ilikkan, Ozge; Bagdat, Elif SeymaThis study evaluated the effect of Arthrospira platensis and Chlorella vulgaris on kefir microbiota, total phenolic content, antioxidant activity, and physicochemical properties such as pH, Brix, total dry matter, and titratable acidity. The results showed that the addition of algae at concentrations of 0.5% (w/v) and 1% (w/v) to the kefir did not change the acceptable physicochemical properties of kefir. The acidity of the microalgae-enriched kefirs increased with increasing algae concentration. Total phenolic content and antioxidant activity of all kefir samples fortified with algae were higher than those of the control. However, the addition of A. platensis exhibited better prebiotic activity than C. vulgaris on kefir microbiota during storage. Principal component analysis and overall results showed that A. platensis was a better candidate for improving the nutritional value of kefir.