Scopus İndeksli Açık & Kapalı Erişimli Yayınlar
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Item Nail and hair findings developing in patients treated for COVID-19 infection fluorescence of keratinized tissues on Wood's lamp in COVID-19 disease(2022) Coban, Kubra; Durusoy, Cicek; 35174612Background: The new severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) is the causative agent of coronavirus 2019 (COVID-2019) disease. A wide variety of symptoms of the disease has been frequently reported in the literature in recent years. However, information on the findings in keratinized tissues is still limited. Data on changes in keratinized tissues such as nails, teeth and hair, and oral mucousa due to drugs used in the treatment of this disease are also extremely insufficient. Aim With this study, it was aimed to evaluate the changes in the keratinized tissues of our patients with COVID-19, who are frequently encountered in the Ear Nose and Throat outpatient clinic. Materials and Method: The study was carried out on patients who applied to Baskent University Ear Nose and Throat clinic. There were 3 groups. The first group consisted of patients diagnosed with COVID-19 and received relevant medical treatments, the second group included individuals who have never experienced COVID-19 infection but have been vaccinated against COVID-19, and the third group is the control group with normal healthy individuals who have never been diagnosed with COVID-19 infection and have not been vaccinated so far. With the Wood's lamp, fluorescent changes in nails, hair, tooth, and the oral mucousa were recorded. Results: A total of 124(75 females, 49 males) patients were included in the study. Positive Wood's finding was significantly higher in COVID-19 group(Group 1) who received Favipravir when compared with individuals who did not receive Favipravir (p < 0.001). Wood's positivity was not detected in any of the individuals who did not use favipravir. The rate of determining Wood's positivity in favipravir users decreases after 58 days. Discussion: Accordingly, Favipravir accumulation in the kretainized tissues manifest positive Wood's sign in our study. Conclusion: The adverse effects of the accumulation of the drugs-mainly Favipravir-used in the treatment of COVID-19 disease, have not yet been clearly demonstrated so far. Revealing the findings in these tissues with this study will pave the way for investigating changes or drug sequestrations in other organs in the long term.Item Evaluation of the nasal septal body in pediatric patients(2021) Coban, Kubra; Ozer, Fulya; Akdogan, M. Volkan; 0000-0001-5381-6861; ABC-1809-2020Objective: The nasal septal body (NSB) is a fusiform shaped dynamic structure and the widest part of the anterior septum. It consists of a thickened septal cartilage, bone, glandular, and vasoactive structures covered by mucous membranes. Hence, it plays a role in nasal airflow and humidification. This study evaluated the size of this structure in pediatric patients with allergic rhinitis and other sinonasal pathologies. Methods: The study was conducted at the Baskent University Hospital otolaryngology department between 2015 and 2019. A total of 117 children were enrolled, including 96 patients and 21 controls. The study group was divided into 3 sub-groups: group 1, with sinonasal pathologies and allergic rhinitis; group 2, with sinonasal pathologies only; and group 3, with allergic rhinitis only. The widest horizontal part of the NSB was measured on paranasal coronal computed tomography sections. Results: The mean NSB width in the patient and control groups were 1.00 +/- 0.19 cm and 0.90 +/- 0.16 cm, respectively. The NSB was significantly larger in the patient groups compared to the controls (p=0.032). There was no significant difference among the study sub-groups in terms of NSB width (p=0.215). A significant positive correlation was found between age and NSB in the patient and control groups (r=0.366, p=0.000 and r=0.632, p=0.002, respectively). There was a significant correlation between age and NSB in group 1 and group 2 (r=0.354, p=0.015 and r=0.447, p=0.010, respectively). Conclusion: The nasal septal body is significantly larger in children with comorbid sinonasal pathologies and allergic rhinitis compared to the control group.Item Audiovestibular Dysfunction in Patients with Fibromyalgia Syndrome(2021) Tuncer, Mehbube; Coban, Kubra; Erbek, H.Seyra; 34309557OBJECTIVES: Fibromyalgia syndrome is a disorder of widespread pain with unknown etiology. These patients frequently suffer from otologic complaints. This study aims to analyze the audiovestibular functions in patients with fibromyalgia syndrome. METHODS: The study included 33 fibromyalgia patients and 33 healthy volunteers. All the study subjects underwent audiological assessment, multifrequency tympanometry, transient otoacoustic emission, and ocular and cervical vestibular-evoked myogenic potentials tests. RESULTS: Pure-tone hearing thresholds of right and left ears were found to be decreased in fibromyalgia patients compared to controls (P < 0.05). Middle ear resonance frequency values were significantly decreased in patients with fibromyalgia syndrome compared to controls (P <.05). The values for signal-to-noise ratios were higher in controls than in the FMS patients. The difference was significant for 1000, 2000, and 4000 Hz (P >.005). Cervical vestibular-evoked myogenic potential waves were obtained in all controls, but could not be obtained in 5 right ears and 4 left ears of the fibromyalgia patients (P <.05). Also, ocular vestibular-evoked myogenic potentials were obtained in all controls, but could not be obtained in 7 right ears and 10 left ears of the patients with fibromyalgia syndrome (P <.05). CONCLUSION: Our findings support the presence of audiovestibular dysfunction in patients with fibromyalgia. Further research that focuses on the pathogenesis of these dysfunctions is required.Item Evaluation of the hearing status in carpenters(2021) Budak, Buse; Coban, Kubra; Erbek, Selim S.; 34389884Purpose Carpenters are constantly exposed to a noise level of 82-100 dB(A) in their professional lives. The aim of this study is to evaluate the hearing status of carpenters with pure -tone audiometry and transient evoked otoacoustic emissions test. Methods A total of 62 individuals were enrolled. The study group consisted of 31 carpenters and the controls were age and sex matched healthy individuals who were not exposed to continuous or sudden noise. Results The average age of the carpenters is 44.58 +/- 10.33, the average age of the control group is 41.84 +/- 8.65 and there was no statistically significant difference (p = 0.262). There was a significant hearing loss in the study group nearly at all frequencies when compared to the control group (p < 0.05). The emission values of the right and left ears of the carpenters were significantly lower than the controls at 2000 and 2800 Hz (p < 0.05). Conclusion Accordingly, carpenters seem to be susceptible to the development of noise-induced hearing loss.