Scopus İndeksli Açık & Kapalı Erişimli Yayınlar

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Can Hepatitis A Vaccine Provide Protection Against COVID-19?
(2020) Sarialioglu, Faik; Apak, Fatma Burcu Belen; Haberal, Mehmet; 0000-0002-9278-6703; 0000-0002-3462-7632; 0000-0002-8257-810X; 32279655; AAJ-8171-2021; AAJ-8097-2021; AAL-7766-2021
Efficacy and safety of novel glycopeptides versus vancomycin for the treatment of gram-positive bacterial infections including methicillin resistant Staphylococcus aureus: A systematic review and meta-analysis
(2021) Jame, Wissal; Basgut, Bilgen; Abdi, Abdikarim; 34843561
Objective To compare between current evidence of novel glycopeptides against vancomycin for the treatment of gram-positive bacterial infections. Methodology A systematic review and meta-analysis was done. Major databases were searched for eligible randomized control trials that assessed clinical success, microbiological success and safety profile of novel glycopeptides versus vancomycin for infections caused by gram-positive bacteria. Results This meta-analysis included eleven trials (7289 participants) comparing telavancin, dalbavancin and oritavancin with vancomycin. No differences were detected between novel glycopeptides and vancomycin for the treatment of skin and soft tissue infections (SSTIs) among modified intent-to-treat patients (OR: 1.04, CI: 0.92-1.17) as well as within the clinically evaluable patients (OR: 1.09, CI: 0.91-1.30). Data analysed from SSTIs, HAP and bacteremia studies on telavancin showed insignificant high clinical response in microbiologically evaluable patients infected with methicillin resistant Staphylococcus aureus (MRSA) (OR: 1.57, CI: 0.94-2.62, p: 0.08) and in the eradication of MRSA (OR: 1.39, CI: 0.99-1.96, P:0.06). Dalbavancin was non-inferior to vancomycin for the treatment of osteomyelitis in a phase II trial, while it was superior to vancomycin for the treatment of bacteremia in a phase II trial. Data analysed from all trials showed similar rates of all-cause mortality between compared antibiotics groups (OR: 0.67, CI: 0.11-4.03). Telavancin was significantly related with higher adverse events (OR: 1.24, CI: 1.07-1.44, P: <0.01) while dalbavancin and oritavancin were associated with significant fewer adverse events (OR: 0.73, CI: 0.57-0.94, p: 0.01; OR: 0.72, CI: 0.59-0.89, p: <0.01 respectively). Conclusion Efficacy and safety profiles of both dalbavancin and oritavancin were the same as vancomycin in the treatment of gram-positive bacterial infections in different clinical settings, while telavancin might be an effective alternative to vancomycin in MRSA infections, but caution is required during its clinical use due to the high risk of adverse events, especially nephrotoxicity.
Emerging and reemerging respiratory viral infections up to Covid-19
(2020) Celik, Ilhami; Saatci, Esma; Eyuboglu, Fusun Oner; 32293833; AAR-4338-2020
Infectious diseases remain as the significant causes of human and animal morbidity and mortality, leading to extensive outbreaks and epidemics. Acute respiratory viral diseases claim over 4 million deaths and cause millions of hospitalizations in developing countries every year. Emerging viruses, especially the RNA viruses, are more pathogenic since most people have no herd immunity. The RNA viruses can adapt to the rapidly changing global and local environment due to the high error rate of their polymerases that replicate their genomes. Currently, coronavirus disease 2019 (COVID-19) is determined as an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which was first identified in 2019 in Wuhan. Herein we discuss emerging and reemerging respiratory viral infections till to SARS-CoV-2.
Ethical Issues Encountered within the Context of an Adrenoleukodystrophy Case
(2020) Karabulut, Seyhan Demir; Yildirim, Rifat Vedat; Celik, Zerrin Yilmaz; 0000-0001-5473-573X; AAB-3163-2021
Adrenoleukodystrophy (ALD) is a disorder of peroxisomal fatty acid beta oxidation which results in the accumulation of very-long chain fatty acids in tissues throughout the body. The most severely affected tissues are the myelin in the central nervous system, the adrenal cortex and the Leydig cells in the testes. Clinically, ALD is a heterogeneous disorder, presenting with several distinct phenotypes, and no clear pattern of genotype-phenotype correlation. As an X-linked disorder, ALD presents most commonly in males, however approximately 50% of heterozygote females show some symptoms later in life. In the case presented in this paper, the subject is a 19-year-old woman who applied to the genetics polyclinic. Her grandmother, mother and two siblings have ALD. She wonders and is concerned about her status as a carrier. Her parents do not want their daughter to take a diagnostic test and the sick siblings in in the family are hidden from the person to whom she will get married. The patient applied to the genetic outpatient clinic without the knowledge of her family, the first tests were performed and the other sick patients at home were also suggested to take a test for the diagnosis to be confirmed. That the patient was prevented from taking a test, that her health information was not shared with the person she will get married to and the patient's wish to have her six-year-old sister/brother, who can not make his/her own decisions take the test, necessitated the discussion of the case ethically.
From Marcia to the Present: A Review in the Context of Status and Process Models
(2021) Kaya, Meva Demir; Cok, Figen
Marcia's Identity Status Theory, based on Erikson's views, is the basis for many identity studies. Although identity status is the best known among the statuses that Marcia has defined, there are statuses specific to each stage from advanced adolescence to old age. Since the statuses in question are based on the narratives of individuals through semi-structured interview forms, the narrative identity approach, which is a fairly new field in identity studies, draws attention. The narrative identity approach, which has functions such as personal purpose, integrity and creating meaning, is based on Erikson's studies as in other identity studies. In this context, Marcia discussed both the narrative identity approach based on Erikson's views and the explanations of Erikson's identity development. On the other hand, models influenced by Marcia's views and focused on the process in identity development in recent years also provide up-to-date information on identity literature. Therefore, in this study, firstly, each of the statuses in psychosocial stages is discussed, and then the theoretical basis for the narrative identity approach is presented. Finally, there are a five-dimensional identity formation model and a three-dimensional identity development model that deal with identity in the context of the process.
Incidence and outcome of Kaposi sarcoma after hematopoietic stem cell transplantation: a retrospective analysis and a review of the literature, on behalf of infectious diseases working party of EBMT
(2020) Cesaro, Simone; Tridello, Gloria; van der Werf, Steffie; Bader, Peter; Socie, Gerard; Ljungman, Per; McQuaker, Grant; Giardino, Stefano; ckan-Cetinkaya, Duygu; Anagnostopoulos, Achilles; Ozdogu, Hakan; Schots, Rik; Jindra, Pavel; Ladetto, Marco; Schroyens, Wilfried; Mikulska, Malgorzata; Styczynski, Jan; 0000-0002-8902-1283; 31435035; AAD-5542-2021
The incidence, the clinical characteristics, and the outcome of Kaposi sarcoma (KS) in patients after hematopoietic stem cell transplantation (HSCT) were assessed. During the period 1987-2018, 13 cases of KS were diagnosed, 3 females and 10 males, median age of 50 years, median time from HSCT of 7 months. KS had an incidence of 0.17% in allogeneic and 0.05% in autologous HSCT. HHV-8 was documented in eight of nine tumor tissue samples assessed. The organ involvement was: skin in nine, lymph nodes in six, oral cavity in four, and visceral in three patients, respectively; seven patients had >1 organ involved. Five patients had immunosuppression withdrawn, whereas four and three patients received radiotherapy and chemotherapy, respectively. Eight patients are alive (median follow-up 48 months, range 5-128), whereas five patients died after a median time of 8 months from the diagnosis of KS. However, no death was caused by KS. We conclude that the incidence of KS after HSCT is very low. Although KS can be managed with the reduction of immunosuppression, visceral forms may require chemotherapy and/or radiotherapy. The low prevalence of KS indicates that screening for HHV-8 serology and surveillance for HHV-8 viremia are not indicated in HSCT patients.
Intraoperative neuromonitoring of the RLNs during TOETVA procedures
(2020) Erol, Varlik; Dionigi, Gianlorenzo; Barczynski, Marcin; Zhang, Daqi; Makay, Ozer; 32175253
Transoral endoscopic thyroidectomy by vestibular approach (TOETVA) is now being performed in increasing frequency and getting more and more attention. TOETVA is carried out through three incisions in the oral vestibular area. Thyroidectomy is performed endoscopically using conventional laparoscopic instruments, an energy based device and neuromonitoring instruments. Intraoperative neuromonitoring is one of the tools of utmost importance, used for navigation and confirmation of the functional integrity of the recurrent nerve during TOETVA. The aim of this study is to give information about the standards and technique of intraoperative neuromonitoring of the recurrent laryngeal nerves during TOETVA procedures. TOETVA is a safe technique with no visible scarring and hence resulting in an excellent cosmetic effect. We believe that neuromonitoring of the recurrent laryngeal nerves also minimizes the risk of nerve damage and is an essential safety component in this technique.
New perspectives by imaging modalities for an old illness: Rheumatic mitral stenosis
(2020) Oz, Tugba Kemaloglu; Tok, Ozge Ozden; Sade, Leyla Elif; 0000-0003-3737-8595; 32120357; AAQ-7583-2021
Mitral stenosis (MS) is a progressive and devastating disease and most often occurs among young women. Given its considerable prevalence in Mediterranean and Eastern European countries according to the Euro Heart Survey, new imaging modalities are warranted to improve the management of patients with this condition. A wide spectrum of abnormalities occurs involving all parts of this complex structure and causing different grades of MS and/or regurgitation as a consequence of rheumatic affection. Novel imaging modalities significantly improved the assessment of several aspects of this rheumatic destructive process including the morphological alterations of the mitral valve (MV) apparatus, left atrial (LA) function, LA appendage, right and left ventricular (LV) functions, and complications, namely, atrial fibrillation and thromboembolic events. Furthermore, new imaging modalities improved the prediction of outcome of patients who underwent percutaneous balloon mitral comissurotomy and changed the paradigm of patient selection for intervention and risk stratification. The present review aimed to summarize the role of new multimodality, multiparametric imaging approaches to assess the morphological characteristics of the rheumatic MS and its associated complications, and to guide patient management.
Predicting Infections Using Computational Intelligence - A Systematic Review
(2020) Baldominos, Alejandro; Puello, Adrian; Ogul, Hasan; Asuroglu, Tunc; Colomo-Palacios, Ricardo; 0000-0003-4153-0764
Infections encompass a set of medical conditions of very diverse kinds that can pose a significant risk to health, and even death. As with many other diseases, early diagnosis can help to provide patients with proper care to minimize the damage produced by the disease, or to isolate them to avoid the risk of spread. In this context, computational intelligence can be useful to predict the risk of infection in patients, raising early alarms that can aid medical teams to respond as quick as possible. In this paper, we survey the state of the art on infection prediction using computer science by means of a systematic literature review. The objective is to find papers where computational intelligence is used to predict infections in patients using physiological data as features. We have posed one major research question along with nine specific subquestions. The whole review process is thoroughly described, and eight databases are considered which index most of the literature published in different scholarly formats. A total of 101 relevant documents have been found in the period comprised between 2003 and 2019, and a detailed study of these documents is carried out to classify the works and answer the research questions posed, resulting to our best knowledge in the most comprehensive study of its kind. We conclude that the most widely addressed infection is by far sepsis, followed by Clostridium difficile infection and surgical site infections. Most works use machine learning techniques, from which logistic regression, support vector machines, random forest and naive Bayes are the most common. Some machine learning works provide some ideas on the problems of small data and class imbalance, which can be of interest. The current systematic literature review shows that automatic diagnosis of infectious diseases using computational intelligence is well documented in the medical literature.
Radiological approaches to COVID-19 pneumonia
(2020) Akcay, Sule; Ozlu, Tevfik; Yilmaz, Aydin; 0000-0002-8360-6459; 32299200; AAB-5175-2021
COVID-19 pneumonia has high mortality rates. The symptoms are undiagnostic, the results of viral nucleic acid detection method (PCR) can delay, so that chest computerized tomography is often key diagnostic test in patients with possible COVID-19 pneumonia. In this review, we discussed the main radiological findings of this infection.
The Role of miRNA in Endometriosis
(2021) Bilgili, Gamze; Verdi, Hasibe; Zeyneloglu, B. Hulusi; Tohma, Y. Aytac; Atac, F. Belgin
Endometriosis is characterized by the presence of endometrial gland and stroma outside of the endometrial cavity. Not only the complex nature of disease limits the identification of the pathogenic mechanisms of endometriosis but the lack of simple diagnostic procedure is the major limitation. So identification of a simple clinical tool for the diagnosis of endometriosis has become a high priority research objective. MicroRNAs (miRNAs), a class of small noncoding RNA molecules, have been recognized as key post- transcriptional regulators those may associate with endometriosis. In the present paper, we aimed to review the studies which focused on the prognosis and diagnosis of the endometriosis and miRNAs. As studies on the role of miRNAs in the pathogenesis of endometriosis increase in the literature, new ideas can be put forward for early diagnosis, prevention and treatment of the endometriosis.
The Use of Fundus Autofluorescence in Dry Age-Related Macular Degeneration
(2021) Keskek, Nadime Sahinoglu; Sermet, Figen; 0000-0001-8544-103X; 34187152; T-4258-2017
Fundus autofluorescence (FAF) has been a well-known imaging method for quite some time. However, with developing technologies and novel imaging devices, FAF is being used more often to diagnose and monitor retinal diseases. The density of lipofuscin (LF) and other fluorophores in the retina have a determining role in FAF images. In dry age-related macular degeneration (AMD), hyperautofluorescence is seen in cases of increasing LF in the retina pigment epithelium, whereas hypoautofluorescence is detected in decreasing LF resulting from geographic atrophy. In recent years, studies have shown that FAF images provide prognostic information in patients with AMD. This review aims to highlight the importance of FAF imaging in dry AMD.