Başkent Üniversitesi Dergileri

Permanent URI for this collectionhttps://hdl.handle.net/11727/13093

Browse

Filters

2010 - 20116

Settings

search.filters.applied.f.language: search.filters.language.enSubject: search.filters.subject.Renal transplant

Search Results

Now showing 1 - 6 of 6
  • No Thumbnail Available
    Item
    Chronic Myeloid Leukemia Within a Year of Kidney Transplant With Elevated Alkaline Phosphatase Correlated With Imatinib Therapy
    (Başkent Üniversitesi, 2011-10) Sayar, Hamid; Mehta, Rakesh; Taber, Tim E.; Sharfuddin, Asif A.
    The incidence of certain malignancies is significantly higher after organ transplant. However, there are rare reports of chronic myeloid leukemia in the posttransplant setting. The average reported interval between a transplant and the diagnosis of chronic myeloid leukemia is 44 months (range, 10-96 mo). We report 2 patients with chronic myeloid leukemia within 1 year of a kidney transplant, which is significantly shorter than those previously reported. Both patients were receiving mycophenolate mofetil and tacrolimus for immunosuppression. They were treated with imatinib for chronic myeloid leukemia, and both patients demonstrated an isolated elevation of serum alkaline phosphatase that was directly correlated with imatinib. Despite a potential interaction between the 2 drugs, blood levels of tacrolimus and imatinib were not elevated during the course of treatment. Isolated elevation of alkaline phosphatase in this particular setting has not been reported previously.
  • No Thumbnail Available
    Item
    Aspergillus Fumigatus Spondylodiskitis in Renal Transplant Patient: Voriconazole Experience
    (Başkent Üniversitesi, 2011-08) Ersoy, Alparslan; Ener, Beyza; Akalin, Halis; Oruc Koc, Aysegul; Dizdar, Oguzhan Sitki
    The incidence of invasive aspergillosis has increased after solid organ transplant. However, aspergillus osteomyelitis in vertebrae is rare. We report a case of aspergillus spondylodiskitis after pulmonary aspergillosis in a renal transplant recipient. He was treated by antifungal therapy and surgical intervention. The transplantist should be alert for a diagnosis of aspergillus spondylodiskitis in recipients who developed back pain after aspergillosis infection in other sites.
  • No Thumbnail Available
    Item
    Ten-year Follow-up of Basiliximab Induction Therapy for Live-donor Kidney Transplant: A Prospective Randomized Controlled Study
    (Başkent Üniversitesi, 2011-08) Sheashaa, Hussein A.; Ghoneim, Mohamed A.; Sobh, Mohamed A.; Ismail, Amani M.; Rashad, Rashad H.; Bakr, Mohamed A.
    Objectives: The effect of basiliximab induction therapy on long-term patient and graft survival is not clear. We sought to evaluate if there is any advantage to routine basiliximab induction on the long-term outcome of living-related donor kidney transplants. Materials and Methods: One hundred adult recipients with their first kidney allograft were randomized into 2 treatment groups; 1 group received basiliximab, and the second served as a control. All patients received a maintenance triple immunosuppressive therapy (steroids, cyclosporine, microemulsion, and azathioprine). We followed them for 10 years. Results: Basiliximab reduced the proportion of patients who experienced an acute rejection in the first year (18/50) when compared with the control group (31/50) (P = .009), and in 10 years (28/50) when compared with controls (37/50) (P = .059). The cumulative steroid dosage used throughout the study was significantly lower in the basiliximab group. The overall incidence of posttransplant complications was comparable among the 2 groups. There was no significant difference in patient and graft survival; 10-year patient and graft survival were 92% and 76% for basiliximab and 90% and 68% for the control group. Conclusions: Routine basiliximab induction significantly reduces the incidence of acute rejection without any noticeable effects on the long-term renal transplant outcome.
  • No Thumbnail Available
    Item
    Lipid Disturbances Before and After Renal Transplant
    (Başkent Üniversitesi, 2011-08) Razeghi, Effat; Pourmand, Gholamreza; Ashraf, Haleh; Shafipour, Mohammadreza
    Objectives: Hyperlipidemia is a significant metabolic disorder that is commonly encountered in renal transplant recipients. This study was conducted to investigate lipid disturbances and define its pattern in kidney recipients. Materials and Methods: The records of 103 patients who had undergone a renal transplant between the years of 2004 and 2005 were retrospectively investigated. The lipid profile of these patients including total cholesterol, low-density lipoproteins, high-density lipoproteins, and triglyceride levels before and within 2 years’ follow-up after transplant was evaluated. The demographics of the patients, cause of the end-stage renal failure, along with their immunosuppressive regimens were also considered. Results: The study group included 43 women (41.8%) and 60 men (58.2%) (mean age, 39.25 ± 13.9 y). After transplant, laboratory analyses yielded significantly increased levels of total cholesterol, low-density lipoproteins, triglyceride levels, and high-density lipoproteins despite statin therapy, and the most important predictor for developing hypercholesterolemia and hypertriglyceridemia—pre-existing dyslipidemia. The effects of the various drugs on lipid metabolism were not different. These effects seen on the lipid profiles also were independent of the patients’ age, sex, and cause of end-stage renal failure. Conclusions: Despite statin treatment, renal transplants in our subjects were associated with a characteristic pattern of lipid disturbance with raised total cholesterol, low-density lipoproteins, high-density lipoproteins, and a concomitant increase in triglycerides. A more-aggressive approach to managing posttransplant hyper­cholesterolemia is warranted, especially in patients with pre-existing dyslipidemia.
  • No Thumbnail Available
    Item
    Swine H1N1 Infection in a Renal Transplant Recipient
    (Başkent Üniversitesi, 2010-12) Ozkan, Gulsum; Kazaz, Nazli; Cansiz, Muammer; Oztuna, Funda; Kaynar, Kubra; Ulusoy, Sukru
    Influenza pandemics have been observed in several periods throughout history. The first influenza pandemic of the 21st century began in Mexico in 2009 and has spread rapidly all over the world. Swine H1N1 has been officially declared a pandemic by the World Health Organization in June 2009. As has been observed in previous pandemics, pregnant women, adolescents, and immunosuppressed individuals are affected more severely in this pandemic. Despite several reports about the pandemic, there have not been any reports of swine H1N1 infection in individuals who underwent renal transplant. The aim of the current study was to present oseltamivir therapy in a swine H1N1-infected patient who underwent renal transplant 10 months earlier, and was thus under immunosuppressive treatment. To the best of our knowledge, this is the first case report of a swine H1N1 infection in a renal transplant recipient.
  • No Thumbnail Available
    Item
    Low Prevalence of BK Virus Nephropathy on Nonprotocol Renal Biopsies in Iranian Kidney Transplant Recipients: One Center’s Experience and Review of the Literature
    (Başkent Üniversitesi, 2010-12) Soleymanian, Tayebeh; Najafi, Iraj; Hakemi, Monirsadat; Saddadi, Fereshteh; Amin, Manoochehr; Naderi, Gholamhosein; Ganji, Mohammad Reza; Sotoodeh, Masoud; Rasulzadegan, Mohammad Hosein
    Background: BK virus-associated nephropathy in renal transplant recipients has been increasing in frequency in recent years. This rise is probably because of widespread use of highly potent immunosuppressive regimens, and increased immunosuppression load leads to inability of the recipients to increase a successful antiviral immune response. The incidence of BK virus-associated nephropathy in different reports is between 1% and 10%, with an allograft loss in significant numbers of patients, especially when timely diagnosis and treatment is not restored. We report our experience on BK virus nephropathy in our institute. Materials and Methods: All renal transplant biopsies performed at our center between 2001 and 2006 were immunohistochemically screened for the presence of PV-specific protein (SV40 Ag). The histologic diagnosis of BK virus-associated nephropathy was made upon the observation of morphologic changes in tubular epithelium and confirmation with immunohistochemical staining. We reviewed the clinical records of the subjects for demographic, clinical, and laboratory data. Results: BK virus nephropathy was found in 0.93% of all investigated allograft biopsies (1/108) and in 1.04% of all recipients (1/96; mean age of recipients, 36.48 ±14.10 years; age range, 13-74 years); 54 of them were male (57%). Type of kidney transplant was living-unrelated donor 76 (79%), living-related donor 13 (14%), and deceased donor 7. Seventeen patients (18%) were transplanted for a second time. Immunosuppressive drugs in 87 of recipients (90%) were cyclosporine, mycophenolate mofetil, and prednisolone. Our patient who developed BK virus-associated nephropathy 9 months after transplant was a 37-year-old man on prednisone, cyclosporine, and azathioprine immunosuppresion. He lost his graft 4 months after diagnosis. Conclusions: Although BK virus nephropathy after renal transplant is uncommon, it is a serious complication causing loss of the allograft. It should be included in the clinical differential diagnosis of transplant dysfunction.