Wos Kapalı Erişimli Yayınlar
Permanent URI for this collectionhttps://hdl.handle.net/11727/10753
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Item How hematopoietic stem cell transplantation activity was affected during the pandemic? JACIE accredited center reflex(2022) Kozanoglu, I.; Tepebasi, S.; Kursun, E.; Sen, N.; Unsal, Z. E.; Kis, C.; Boga, C.; Yesilagac, H.; Demiroglu, Y. Z.; Pocan, G.Item TBI/fludarabine versus busulfan/fludarabine as a myeloablative conditioning for adults with acute myeloid leukemia treated with allo-HCT. A study from the ALWP of the EBMT(2022) Swoboda, R.; Labopin, M.; Giebel, S.; Schroeder, T.; Kroeger, N.; Arat, M.; Savani, B.; Spyridonidis, A.; Hamladji, R. M.; Potter, V.; Deconinck, E.; Yakoub-Agha, I.; Rambaldi, A.; Ozdogu, H.; Sanz, J.; Nagler, A.; Mohty, M.Item Traveling Repairmen Problem: A Biogeography-Based Optimization(2022) Uzun, Gozde Onder; Dengiz, Berna; Kara, Imdat; Karasan, Oya EkinTraveling Repairman Problem (TRP), which is also known by names cumulative traveling salesman problem, the deliveryman problem and the minimum latency problem, is a special variant of Traveling Salesman Problem (TSP). In contrast to the minimization of completion time objective of TSP, the desired objective of TRP is to minimize the cumulative latency (waiting time or delay time) of all customers. In this paper, a generalized version of TRP with multi depots and time windows, namely Multi Depot Traveling Repairman Problem with Time Windows (MDTRPTW) is considered. A group of homogeneous repairmen initiate and finish their visit tours at multiple depots. Each customer must be visited exactly by one repairman within their provided earliest end latest times. Being a challenging Nondeterministic Polynomial-hard (NP-hard) optimization problem, exact solution approaches are not expected to scale to realistic dimensions of MDTRPTW. Thus, we propose a biogeography-based optimization algorithm (BBOA) as a metaheuristic approach to solve large size MDTRPTW problems. The proposed metaheuristic is analyzed in terms of solution quality, coefficient of variation as well as computation time by solving some test problems adapted from the related literature. The efficacy of the proposed solution methodology is demonstrated by solving instances with 288 customers within seconds.Item A diffusion tensor imaging study in schizophrenia patients with clozapine induced obsessive compulsive symptoms(2023) Ay, Sule Bicakci; Oguz, Kader K.; Eroglu, Elcin Ozcelik; Has, Arzu Ceylan; Ertugrul, Aygun; 36382404Objective The aim of this study was to evaluate brain connectivity by diffusion tensor imaging (DTI) in schizophrenia patients with clozapine-induced obsessive compulsive symptoms (OCS). Methods Eighteen schizophrenia patients, nine of which had clozapine-induced OCS (Clz-OCS (+)), 9 without OCS (Clz-OCS (-)) and 9 healthy controls were included. Psychopathology was evaluated with Positive and Negative Syndrome Scale and Yale-Brown Obsession and Compulsion Scale in the patient groups. All groups were assesed with neurocognitive tests and DTI. Results Tract-Based Spatial Statistics based comparison of DTI revealed lower fractional anisotropy in the genu of corpus callosum (CC), right cingulum, left frontal white matter (WM) in the Clz-OCS (+) group, compared to controls. Fractional anisotropy was found to be lower in the bilateral occipital WM and higher in the bilateral medial temporal regions, anterior limb of internal capsule, cingulum, frontoparietal peripheral WM, right external capsule and genu of CC in Clz-OCS (+) patients compared to Clz-OCS (-). Conclusions WM integrity in several pathways such as cortico-striato-thalamo-cortical circuitry and orbito-frontal tracts seems to be affected differently in patients with Clz-OCS (+). Different neuroplastic effects of clozapine leading to occurrence of OCS in a subgroup of patients is possible, and needs further evaluation by longitudinal follow-up studies.Item The Inventory of Flood Disasters in Turkey(2022) Gurer, Ibrahim; Ucar, IbrahimTurkey is located both Europe and Asia, and covers an area of 780 580 km(2) including the lakes. Turkey undergoes different types of natural disasters because of its geographical location, geomorphology, and topography. Flooding is the second important natural hazard after earthquakes. A flood inventory of the period extending from 1955 to 2020 having a total of about 3250 events was prepared using a simple computer program based on Excel for easy access to different geomorphologic parameters such as surface areas of river basins, slope, geological structure, vegetative cover, type of precipitation, and the elevation above mean sea level (a.m.s.l) and hydro-meteorological parameters. In the same inventory each flood has been defined with damages on human as lost and injured, size of flooded area and loss of wealth (not exact information for wealth). By categorization of the available data in hand, spatial and time distributions of past flood events were determined. In large basins, negative impacts are more closely related to climatic factors, but in small watersheds, the urbanization along the rivers, internal migration, regional planning, urban drainage infrastructure are more important on negative impacts. In order to prevent the floods and minimize the adverse effects to property, both structural and non-structural solutions are applied in Turkey. Two case studies added to show the solutions.Item Hydropower Outlook of Turkey in 2021(2022) Gurer, IbrahimTurkey is located partly on Europe and also on Asia, and has a surface area of 780 580 km(2) and a population of 84.6 million and electric energy is essential for the everyday life. The annual per capita consumption of electricity is mainly used to measure the prosperity of a nation. The energy use in a country increases not only with population increase but also by improving the living standards of people and industrial development. Turkey being a non-oil-producing country at present, therefore needs to import fossil fuels (like natural gas and fuel oil) as the main source of electric energy. The utilization of fossil fuels for energy production by thermal power plants is one of the main sources of air pollution. The consumption of imported energy sources should be reduced for the environmental, economic, and political reasons. As the electricity need of the country is increasing continuously, more energy from the renewables and national resources must be produced. Hydropower plants (HPPs) provide clean, fast, flexible electricity generation. The amount of electricity that aHPP can produce basically depends on the available flow rate (Q) and the head (H). Very briefly the greater the flow rate and the net head, the more electricity can be produced in a HPP. The first hydropower station of Turkey had been opened at Tarsus town in 1929. Number of hydropower installations and total installed capacity has increased especially after the 1960s. In 2020, the Turkish electric production values were 32.9% from HPPs, 27.2% from thermal plants working with natural gas, 21.3% from thermal plants working with coal, 8.8% fromwind power plants, 6.8% from the sun, 1.6% from geothermal plants, and about 1.4% from other types of sources. Technically and economically feasible total hydroelectric energy potential of Turkey is 180 billion kWh/year, of which 160 billion kWh/year has been developed and completed. With 714 completed facilities and 31,391 MW installed power and 108.0 billion kWh/year of it has been put into operation. With the projects to be established until 2023, a total installed power capacity of 40,000 MW and a generation potential of 135 billion kWh/year will be reached. Because of the very fast increase in energy consumption, and only 22% of total energy is produced from national sources, and 125 billion dollars total investment is needed. Due to the climate change, and the change in the oil prices, the renewable sources such as solar, wind, geothermal, biogas, biomass, hydropower etc. should be developed and put in service as quickly and efficiently as possible. In this paper, the current level of hydropower production and energy saving, and power consumption by different sectors, and the subject matter of the most recent energy figures are given and the future projections are also presented.Item A Rare Triplet Found in a Patient With Drug-Resistant Hypertension: Adnexal-Adrenal Sex Cord-Stromal Tumors and Castleman?s Disease(2022) Erbay, Gurcan; Pehlivan, Umur Anil; Karadeli, Elif; 36158343Adrenal and ovarian sex cord-stromal tumors which originate from the ovarian stroma and adrenal cortex, have an extremely low incidence even alone. Castleman's disease is also one of the rare causes of non-neoplastic lymphadenopathy. The aim of this case report was to contribute to the literature by identifying the coexistence of these three pathologies, which are encountered with a low incidence even alone.A 46-year-old female patient had experienced drug-resistant hypertension. In the laboratory test, electrolyte imbalance was detected. Imaging modalities revealed left adrenal and adnexal mass lesions as well as a right paraspinal intramuscular nodular lesion. When hypertension and electrolyte imbalance were evaluated together with their etiology, it was thought that the left adrenal lesion, which also has a chemical shift, may be compatible with functional adenoma. Left adrenalectomy was planned. The ovarian lesion and right paraspinal intramuscular lesion were also excised during the same session with the suspicion that the ovarian lesion may be hormone-active neoplasia and the intramuscular lesion may be a metastasis. The diagnosis of adnexal-adrenal sex cord-stromal tumors and unicentric Castleman's disease were made histopathologically.Radiologically, it should be kept in mind that the radiological manifestations of adrenal sex cord-stromal tumors can be confused with adrenal adenomas. Even when these extremely rare tumors are encountered, avoiding the "satisfaction of search" plays a crucial role in the identification of additional pathologies that can explain the etiology.Item Turkish validity and reliability of the Cancer Stigma Scale (CASS-T)(2023) Cevik, Banu; Kav, Sultan; Kaynar, Pelinsu; Sahin, Zeynep Kubra; Tekcan, Busra; Ulker, Seymanur; 0000-0003-1396-854X; 35699122Objectives This study is aimed to evaluate the validity and reliability of the Cancer Stigma Scale for the Turkish population (CASS-T). Methods The sample of the study consisted of 412 students of a foundation university located in Ankara, Turkey. The reliability of the CASS was evaluated using the Cronbach alpha reliability coefficient and item-total score correlations. Exploratory factor analyses were applied to examine the factor structure of the scale and its construct validity. To test the time invariance of the scale, the relationships between the scores obtained from the first and second applications were examined using the intraclass correlation coefficient (ICC). Results The Cronbach's alpha coefficient of CASS-T was 0.83. In the factor analysis, it was confirmed that the scale has a six-dimensional structure in parallel to original version, namely Avoidance, Severity, Responsibility, Policy opposition, Awkwardness, and Discrimination. The ICC values all remained in the range that indicates the reliability of the 0.63-0.71 to be substantial. The contribution of the six factors of the CASS-T scale to the variance is 57.8. Significance in results The Turkish version of the CASS was confirmed to have good reliability and validity for evaluating stigma toward cancer in Turkish society.Item SARS-CoV-2 Mutations and their Viral Variants(2022) Cosar, Begum; Karagulleoglu, Zeynep Yagmur; Unal, Sinan; Ince, Ahmet Turan; Uncuoglu, Dilruba Beyza; Tuncer, Gizem; Kilinc, Bugrahan Regaip; Ozkan, Yunus Emre; Ozkoc, Hikmet Ceyda; Demir, Ibrahim Naki; Eker, Ali; Karagoz, Feyzanur; Simsek, Said Yasin; Yasar, Bunyamin; Pala, Mehmetcan; Demir, Aysegul; Atak, Irem Naz; Mendi, Aysegul Hanife; Bengi, Vehdi Umut; Sevel, Guldane Cengiz; Altuntas, Evrim Gunes; Kilic, Pelin; Demir-Dora, Devrim; https://orcid.org/0000-0003-0359-6308; 34580015Mutations in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) occur spontaneously during replication. Thousands of mutations have accumulated and continue to since the emergence of the virus. As novel mutations continue appearing at the scene, naturally, new variants are increasingly observed.Since the first occurrence of the SARS-CoV-2 infection, a wide variety of drug compounds affecting the binding sites of the virus have begun to be studied. As the drug and vaccine trials are continuing, it is of utmost importance to take into consideration the SARS-CoV-2 mutations and their respective frequencies since these data could lead the way to multi-drug combinations. The lack of effective therapeutic and preventive strategies against human coronaviruses (hCoVs) necessitates research that is of interest to the clinical applications.The reason why the mutations in glycoprotein S lead to vaccine escape is related to the location of the mutation and the affinity of the protein. At the same time, it can be said that variations should occur in areas such as the receptor-binding domain (RBD), and vaccines and antiviral drugs should be formulated by targeting more than one viral protein.Item Can we diagnose disk and facet degeneration in lumbar spine by acoustic analysis of spine sounds? (September, 10.1007/s11760-020-01776-3, 2020)(2021) Nabi, Vugar; Ayhan, Selim; Acaroglu, Emre; Ahi, Mustafa Arda; Cetin, Engin; Toreyin, Hakan; Cetin, A. Enis; 0000-0003-0153-3012; U-5409-2018Unfortunately, the authors have missed to include the fifth author name (Engin cetin) in the group.