Wos Kapalı Erişimli Yayınlar

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Antifungal Stewardship
(2019) Kurt-Azap, Ozlem
Invasive fungal infections are commonly detected because of increasing number of immunocompromised patients. Emerging antifungal resistance in addition to high mortality and costs are the triggers for the implementation of antifungal stewardship (AFS) programmes. The aim of stewardship programmes is the quality improvement in health care and better outcomes for the patients rather than the costs. Optimizing the use of antifungal drugs to achieve the best outcomes while minimizing adverse events and the emergence of resistance are the accompanying goals. AFS is less established than antibacterial stewardship because of a narrower and more complex evidence base along with only a few number of available drugs. Rapid diagnostic tools and therapeutic drug monitoring are the key components of the AFS programmes. Available data show that AFS programmes are feasible, sustainable and well accepted and favor the implementation of AFS programmes in routine care.
Burnout among Turkish Physicians: A Systematic Review
(2021) Toktamis, Aydin; Akkucuk, M. Husamettin; https://orcid.org/0000-0003-4569-1143; https://orcid.org/0000-0001-8126-9228; AAJ-2828-2021; AAE-3687-2021
Introduction and objectives: By evaluating systematically and collectively studies examining burnout and accompanying factors of physicians in Turkey. we aimed to obtain a meta-perspective of the relevant reader or researcher. Material and Methods: English and in Turkish databases (Pub Med, Google Scholar, Ulakbim) were searched by using key words of physician, burnout and Turkey to identify Turkish physician burnout studies that have been published. Results: The databases search resulted in finding of forty-nine articles most of which were regional and only seven representing the nationwide perspective. A total of 12,598 physicians were evaluated in the surveys. The calculated mean values, supposedly roughly representing the total universe evaluated in all studies. were 18.3 for emotional exhaustion (EE), 7.9 for depersonalisation (DP) and 20.1 for personal accomplishment (PA), respectively. Conclusion: There is a low level of EE, DP and a high decrease in the sense of PA in physicians working in Turkey. The overall burnout experienced by them is not very high, but also is not very low. Female physicians appear to be at higher risk for EE sub-dimension and the risk of burnout is reduced with increasing age or experience.
Can Hepatitis A Vaccine Provide Protection Against COVID-19?
(2020) Sarialioglu, Faik; Apak, Fatma Burcu Belen; Haberal, Mehmet; 0000-0002-9278-6703; 0000-0002-3462-7632; 0000-0002-8257-810X; 32279655; AAJ-8171-2021; AAJ-8097-2021; AAL-7766-2021
Clinical characteristics of avascular necrosis in patients with Behcet disease: a case series and literature review
(2019) Atas, Nuh; Bitik, Berivan; Varan, Ozkan; Babaoglu, Hakan; Tufan, Abdurrahman; Haznedaroglu, Seminur; Goker, Berna; Ozturk, Mehmet Akif; 30560445
Avascular necrosis (AVN), also known as osteonecrosis, is characterized by death of the osteocytes due to inadequate blood supply caused by various mechanisms. The hip is the most common affected joint followed by knee. Incidence of AVN in rheumatic diseases is variable and high corticosteroid (CS) therapy is a known major risk factor for development of AVN. Data on the AVN in Behcet disease (BD) are limited. The purpose of this study is to examine the clinical and treatment characteristics of BD patients with diagnosis of AVN. Retrospective medical records of 337 BD patients were reviewed. Nine BD patients with AVN were detected. The clinical data of these patients with AVN have been reviewed. All patients had MRI of the symptomatic joints compatible with AVN. All of the nine patients who were diagnosed with AVN were male. Median duration of BD was 7years. Median time between diagnosis of BD and detection of AVN was 3years (1-16years). Multiple joints were involved in seven patients. Six patients had bilateral knee AVN. Six patients had vascular BD. The median time interval between initial CS dose and AVN development was 24months (range=2-100). The median highest daily CS dose was 64mg/day (range=32-80) and median cumulative CS dose prior to AVN was 18g. All of patients had intravenous pulse steroids. CS treatment, smoking and vascular involvement may predispose to AVN in patients with BD. According to this cohort, AVN in BD frequently tended to be in the knee joint and bilateral.
A Critical Review of Implicit Leadership Theory on the Validity of Organizational Actor-National Culture Fitness
(2017) Ozturk, Alperen; Varoglu, M. Abdulkadir; Varoglu, Demet; R-6466-2019; R-6466-2019
According to implicit leadership literature, actor-national culture fitness is a necessity to be labeled as a leader. However, studies which focus on implicit leadership theory and national culture have some contradictory findings. A systematic review of these studies reveals that participants could score high on opposite implicit leadership values and a sufficient theoretical explanation for these surprising results have not been given so far. This paper argues that showing full harmony with the cultural expectations of followers is not a necessity to be seen as a leader. Actors who can fill the cultural gap with their different cultural values can also be labeled as leaders. This paper contends that organizational actors with cultural values differing from those of the followers with certain cultural orientations are more likely to be labeled as leaders. People from individualistic societies may be more prone to label 'team oriented leadership' dimension as their outstanding leadership prototype whereas people from masculine societies may show 'humane oriented leadership' as their outstanding leadership prototype. (C) AIMI Journals
A Framework for Computational Thinking Based on a Systematic Research Review
(2016) Kalelioglu, Filiz; Gulbahar, Yasemin; Kukul, Volkan
Computational Thinking (CT) has become popular in recent years and has been recognised as an essential skill for all, as members of the digital age. Many researchers have tried to define CT and have conducted studies about this topic. However, CT literature is at an early stage of maturity, and is far from either explaining what CT is, or how to teach and assess this skill. In the light of this state of affairs, the purpose of this study is to examine the purpose, target population, theoretical basis, definition, scope, type and employed research design of selected papers in the literature that have focused on computational thinking, and to provide a framework about the notion, scope and elements of CT. In order to reveal the literature and create the framework for computational thinking, an inductive qualitative content analysis was conducted on 125 papers about CT, selected according to pre-defined criteria from six different databases and digital libraries. According to the results, the main topics covered in the papers composed of activities (computerised or unplugged) that promote CT in the curriculum. The targeted population of the papers was mainly K-12. Gamed-based learning and constructivism were the main theories covered as the basis for CT papers. Most of the papers were written for academic conferences and mainly composed of personal views about CT. The study also identified the most commonly used words in the definitions and scope of CT, which in turn formed the framework of CT. The findings obtained in this study may not only be useful in the exploration of research topics in CT and the identification of CT in the literature, but also support those who need guidance for developing tasks or programs about computational thinking and informatics.
Interactions between Helicobacter pylori and gastroesophageal reflux disease
(2019) Yucel, Oya; 0000-0001-5752-7493; 30151653; AAU-1657-2020
Interactions between Helicobacter Pylori (HP) and gastroesophageal reflux disease (GERD) are a complex issue. Several pathophysiological factors influence the development and the course of GERD, HP infection might be only one of these. Many studies emphasize the co-existence of these diseases. HP infection could contribute to GERD through both a protective and an aggressive role. Gastric acid secretion is a key factor in the pathophysiology of reflux esophagitis. Depending on the type of gastritis related to HP, acid secretion may either increase or decrease. Gastritis in corpus leads to hypoacidity, while antrum gastritis leads to hyperacidity. In cases of antral gastritis and duodenal ulcers which have hyperacidity, the expectation is an improvement in pre-existing reflux esophagitis after eradication of HP. In adults, HP infection is often associated with atrophic gastritis in the corpus. Atrophic gastritis may protect against GERD. Pangastritis which leads to gastric atrophy is commonly associated with CagA strains of HP and it causes more severe gastric inflammation. In case of HP-positive corpus gastritis in the stomach, pangastritis, and atrophic gastritis, reflux esophagitis occurs frequently after eradication of HP. Nonetheless, as a predisposing disease of gastric cancer, HP should be treated. In conclusion, as the determinative factors affecting GERD involving in HP, detailed data on the location of gastric inflammation and CagA positivity should be obtained by the studies at future.
Neutrophil Gelatinase-Associated Lipocalin Measured on Clinical Laboratory Platforms for the Prediction of Acute Kidney Injury and the Associated Need for Dialysis Therapy: A Systematic Review and Meta-analysis
(2020) Kavalci, Cemil; 32679151
Rationale & Objective: The usefulness of measures of neutrophil gelatinase-associated lipocalin (NGAL) in urine or plasma obtained on clinical laboratory platforms for predicting acute kidney injury (AKI) and AKI requiring dialysis (AKI-D) has not been fully evaluated. We sought to quantitatively summarize published data to evaluate the value of urinary and plasma NGAL for kidney risk prediction. Study Design: Literature-based meta-analysis and individual-study-data meta-analysis of diagnostic studies following PRISMA-IPD guidelines. Setting & Study Populations: Studies of adults investigating AKI, severe AKI, and AKI-D in the setting of cardiac surgery, intensive care, or emergency department care using either urinary or plasma NGAL measured on clinical laboratory platforms. Selection Criteria for Studies: PubMed, Web of Science, Cochrane Library, Scopus, and congress abstracts ever published through February 2020 reporting diagnostic test studies of NGAL measured on clinical laboratory platforms to predict AKI. Data Extraction: Individual-study-data meta analysis was accomplished by giving authors data specifications tailored to their studies and requesting standardized patient-level data analysis. Analytical Approach: Individual-study-data meta analysis used a bivariate time-to-event model for interval-censored data from which discriminative ability (AUC) was characterized. NGAL cutoff concentrations at 95% sensitivity, 95% specificity, and optimal sensitivity and specificity were also estimated. Models incorporated as confounders the clinical setting and use versus nonuse of urine output as a criterion for AKI. A literature-based meta-analysis was also performed for all published studies including those for which the authors were unable to provide individual-study data analyses. Results: We included 52 observational studies involving 13,040 patients. We analyzed 30 data sets for the individual-study-data meta-analysis. For AKI, severe AKI, and AKI-D, numbers of events were 837, 304, and 103 for analyses of urinary NGAL, respectively; these values were 705, 271, and 178 for analyses of plasma NGAL. Discriminative performance was similar in both meta-analyses. Individual-study-data meta-analysis AUCs for urinary NGAL were 0.75 (95% CI, 0.73-0.76) and 0.80 (95% CI, 0.79-0.81) for severe AKI and AKI-D, respectively; for plasma NGAL, the corresponding AUCs were 0.80 (95% CI, 0.790.81) and 0.86 (95% CI, 0.84-0.8 6). Cutoff concentrations at 95% specificity for urinary NGAL were >580 ng/mL with 27% sensitivity for severe AKI and >589 ng/mL with 24% sensitivity for AKI-D. Corresponding cutoffs for plasma NGAL were >364 ng/mL with 44% sensitivity and >546 ng/mL with 26% sensitivity, respectively. Limitations: Practice variability in initiation of dialysis. Imperfect harmonization of data across studies. Conclusions: Urinary and plasma NGAL concentrations may identify patients at high risk for AKI in clinical research and practice. The cutoff concentrations reported in this study require prospective evaluation.
Plant-based diets to manage the risks and complications of chronic kidney disease
(2020) Carrero, Juan J.; Gonzalez-Ortiz, Ailema; Avesani, Carla M.; Bakker, Stephan J. L.; Bellizzi, Vincenzo; Chauveau, Philippe; Clase, Catherine M.; Cupisti, Adamasco; Espinosa-Cuevas, Angeles; Molina, Pablo; Moreau, Karine; Piccoli, Giorgina B.; Post, Adrian; Sezer, Siren; Fouque, Denis; 32528189
Traditional dietary recommendations for patients with chronic kidney disease (CKD) focus on the quantity of nutrients consumed. Without appropriate dietary counselling, these restrictions can result in a low intake of fruits and vegetables and a lack of diversity in the diet. Plant nutrients and plant-based diets could have beneficial effects in patients with CKD: increased fibre intake shifts the gut microbiota towards reduced production of uraemic toxins; plant fats, particularly olive oil, have anti-atherogenic effects; plant anions might mitigate metabolic acidosis and slow CKD progression; and as plant phosphorus has a lower bioavailability than animal phosphorus, plant-based diets might enable better control of hyperphosphataemia. Current evidence suggests that promoting the adoption of plant-based diets has few risks but potential benefits for the primary prevention of CKD, as well as for delaying progression in patients with CKD G3-5. These diets might also help to manage and prevent some of the symptoms and metabolic complications of CKD. We suggest that restriction of plant foods as a strategy to prevent hyperkalaemia or undernutrition should be individualized to avoid depriving patients with CKD of these potential beneficial effects of plant-based diets. However, research is needed to address knowledge gaps, particularly regarding the relevance and extent of diet-induced hyperkalaemia in patients undergoing dialysis. Emerging evidence suggests that plant-based diets could help to prevent chronic kidney disease (CKD), manage its symptoms and metabolic complications and delay disease progression. Here, the authors discuss the potential risks and benefits of these diets in patients with CKD, as well as implementation strategies and knowledge gaps.
Precision medicine for metastatic colorectal cancer: an evolving era
(2019) Guler, Irem; Askan, Gokce; Klostergaard, Jim; Sahin, Ibrahim Halil; 31475851
Introduction: Metastatic colorectal cancer (CRC) remains a dilemma for cancer researchers with an increasing incidence in the younger patient population. Until the last decade, limited therapeutic options were available for metastatic CRC patients leading to relatively poor clinical outcomes. Areas covered: With advances in genome sequencing technology and reductions in the cost of next-generation sequencing, molecular profiling has become more accessible for cancer researchers and clinical investigators, which has furthered our understanding of the molecular behavior of CRC. This progress has recently translated into significant advances in molecular-based therapeutics and led to the development of new target-specific agents in metastatic CRC patients. In this review article, we extensively elaborate on genomic alterations seen in CRC patients including, but not limited to, EGFR, MMR, BRAF, HER2, NTRKs, FGFR, BRCA1/2, PALB2, POLE, and POLD1 genes, all of which are potentially actionable by either an FDA-approved agent or in a clinical trial setting. Expert opinion: We strongly recommend molecular profiling in metastatic CRC patients during the early course of their disease, as this may provide therapeutic and prognostic information that can guide clinicians to practice precision medicine. Patients with potentially actionable genes should be considered for targeting agents based on molecular alterations.
Primary extranodal lymphoma of the glands. Literature review and options for best practice in 2019
(2019) Belkacemi, Yazid; Sio, Torence T.; Colson-Durand, Laurianne; Onal, Cem; Villa, Salvador; Anacak, Yavuz; Krengli, Marco; Thariat, Juliette; Ugurluer, Gamze; Miller, Robert C.; Mirimanoft, Rene-Olivier; Ozsahin, Mahmut; To, Nhu Hanh; 0000-0002-2742-9021; 30819450; D-5195-2014
Primary extranodal non-Hodgkin's lymphomas (EN-NHL) are a heterogeneous group of malignancies that involve numerous entities with significant difference in terms of tumor site locations, prognostic factors, biology expression, and therapeutic options. In the literature, many EN-NHL types were reported from limited series which only allowed narrow views for elucidating prognostic factors and defining the role of loco-regional therapies in the era of new systemic and biologically targeted therapies. The Rare Cancer Network (RCN), an international multidisciplinary consortium, has published a number of reports on several EN-NHL sites which included many gland locations. In this review, we will focus on the recent literature for a selected number of EN-NHL types in both exocrine and endocrine gland locations. We aim to provide renewed and clear messages for the best practice in 2019 for diagnosis, histopathology, treatments, and also their prognostic implications. We believe that better understanding of molecular and genetic characteristics of these particular diseases is crucial for an appropriate management in the era of personalized treatment developments.
Schistosomiasis and pulmonary hypertension
(2017) Sen, Nazan; 0000-0002-4171-7484; 29135402; AAI-8947-2021
Schistosomiasis is one of the most prevelant parazitic diseases in the world. It is endemic in more than 70 countries, and more than 200 million people worldwide are infected with Schistosoma. Pulmonary hypertension (PHT) is one of the chronic complications of schistosomiasis. The exact pathogenesis of schistosomiasisassociated pulmonary hypertension (S-PHT) remains unclear, although several mechanisms such as parazitic arterial embolisation, pulmonary arteriopathy, and portopulmonary hypertension have been suggested. Pathological pulmonary vascular changes in S-PHT were found similar to those in idiopathic pulmonary arterial hypertension (IPAH). The fact that schistosomiasis is one of the most common causes of pulmonary arterial hypertension (PAH), particularly in the developing countries, underlines the importance of enhancing our knowledge on this disease. Developments in the treatment of PAH have resulted in improved prognosis and significant increase in life expectancy and quality of life in the last two decades, which has enhanced the importance of S-PHT. Schistosomiasis is treated with praziquantel. Nevertheless, there is limited evidence that this treatment is effective for PHT. Although antihelmintic medications do not lead to significant improvement, they have beneficial effects and may slow down disease progression. Using PAH-specific treatments in the patients with schistosomiasis-associated PAH (S-PAH) can improve prognosis. However, inadequate clinical studies and limited sources in the endemic regions restrict extensive usage of these expensive medications. Further studies are required to determine the efficacy of these treatment modalities.
Selective targeting of antiapoptotic BCL-2 proteins in cancer
(2019) Timucin, Ahmet Can; Basaga, Huveyda; Kutuk, Ozgur; 0000-0001-9854-7220; 29846950; AAH-1671-2019
Circumvention of apoptotic machinery is one of the distinctive properties of carcinogenesis. Extensively established key effectors of such apoptotic bypass mechanisms, the antiapoptotic BCL-2 (apoptosis regulator BCL-2) proteins, determine the response of cancer cells to chemotherapeutics. Within this background, research and development of antiapoptotic BCL-2 inhibitors were considered to have a tremendous amount of potential toward the discovery of novel pharmacological modulators in cancer. In this review, milestone achievements in the development of selective antiapoptotic BCL-2 proteins inhibitors for BCL-2, BCL-XL (BCL-2-like protein 1), and MCL-1 (induced myeloid leukemia cell differentiation protein MCL-1) were summarized and their future implications were discussed. In the first section, the design and development of BCL2/ BCL-XL dual inhibitor navitoclax, as well as the recent advances and clinical experience with selective BCL-2 inhibitor venetoclax, were synopsized. Preclinical data from selective BCL-XL inhibitors, which are currently undergoing extensive testing as a single agent or in combination with other therapeutic agents, were further summarized. In the second section, MCL-1 inhibitors developed as potential anticancer agents were reviewed regarding their specificity toward MCL-1. Explicitly, studies leading to the identification of MCL-1, nonselective and selective targeting of MCL-1, and recently initiated clinical trials were compiled in chronological order. Based on these concepts, future directions were further discussed for increasing selectivity in the design of prosurvival BCL-2 member inhibitors.
Sodium-glucose cotransporter-2 inhibitors in heart failure patients: an appraisal of recent cardiovascular outcome trials
(2020) Kocyigit, Duygu; Kocyigit, Alime S.; Hussain, Muzna; 33059407
Although initially introduced as a novel oral glucose-lowering agent class, cumulative evidence from randomized controlled trials (RCTs) have led sodium-glucose cotransporter-2 inhibitors (SGLT2i) to become a component of primary and secondary prevention from atherosclerotic cardiovascular disease in patients with type 2 diabetes mellitus (T2DM). Dapagliflozin, one of the agents of this class, was investigated in 2019 in patients with heart failure (HF) independent of being diagnosed with T2DM at baseline. Since then, many other studies are being undertaken in this class of drugs. Herein, we aimed to review the RCTs, their subgroup and post-hoc analyses that examined the effects of SGLT2i on cardiovascular outcomes (including HF-related outcomes) in patients diagnosed with HF that were published until June 2020. We also summarized the ongoing trials that aim to assess the impact of SGLT2i on cardiovascular outcomes in patients with HF and listed available guideline recommendations regarding the use of SGLT2i for cardiovascular disease management.
Solid Organ Transplant Recipients with Pneumonia in Intensive Care UniT: A Single Center Study
(2020) Yesiler, F. I.; Yazar, C.; Sahinturk, H.; Zeyneloglu, P.; Haberal, M.; 0000-0002-3462-7632; 0000-0002-0612-8481; 0000-0003-0159-4771; AAJ-8097-2021; AAJ-4212-2021; AAJ-1419-2021
A Systematic Literature Review for Personnel Scheduling Problems
(2020) Ozder, Emir Huseyin; Ozcan, Evrencan; Eren, Tamer; 0000-0002-1895-8060; Q-4772-2017
Organizations need to focus on many parameters to reach their goals such as personnel satisfaction at the top level, profit maximization, increasing system efficiency and minimizing costs. By carefully examining the significant effect of personnel scheduling on the production of goods and services, achieving a fair distribution of work among the employees paves the way for higher motivation and performance of the employees, particularly, in production and service industries. In this paper, a systematic literature review (SLR) approach is used to demonstrate the necessity of scheduling studies in order to overcome the deficiencies in auxiliary activity groups. It sheds light on a new and very important areas such as examining the model structures of sector differences, and guiding researchers. New trends and approaches are presented for the personnel scheduling problems. Different classification perspectives are displayed.
Vestibular Illusions and Alterations in Aerospace Environment
(2021) Demir, Abdurrahman Engin; Aydin, Erdinc; 0000-0001-6864-7378; 34386801; AAJ-2379-2021
As the aerospace industry has grown rapidly over the years, aviators and astronauts have been exposed to some abnormal physiological changes arising from the dynamics of the aerospace environment. The vestibular system, encoding linear and angular movements of the head, is one of the main affected systems in which those abnormal changes can occur during flight. Despite the intricate and solid organization, vestibular units are such delicate structures that they can easily be deceived by aerial dynamics and gravity changes. Therefore, it is of vital importance for the continuity of flight safety to be aware of the detrimental alterations and impairments regarding the vestibular system and its reflex pathways. The aim of this paper was to present a review about how a healthy vestibular system is negatively affected within the aerospace environment and how some vestibular disorders become exaggerated or impaired during aviation and space activities.
Visual Hallucinations Induced by Clarithromycin in a Child: A Case Report and Literature Review
(2019) Gokturk, Bahar; Erden, Semih; 31232747
Objective Our aim was to present a child with visual hallucinations possibly associated with oral clarithromycin administration. Case report A 4-year-old child was admitted to our hospital with an onset of visual hallucinations after taking the second dose of clarithromycin by mouth. The symptoms gradually disappeared in a week once the clarithromycin therapy had been discontinued. She was observed for a month without any symptoms or further treatment. She was suspected of having Hoigne syndrome (also called as antibiomania) induced by clarithromycin syndrome. Conclusion This report highlights neuropsychological adverse effects due to therapeutic doses of clarithromycin therapy as a possible adverse effect in children.
What We Learned about COVID-19 So Far? Notes from Underground
(2020) Esendagli, Dorina; 0000-0002-6619-2952; 32584236; ABF-9398-2020
The novel coronavirus pandemic poses a major global threat to public health. Our knowledge concerning every aspect of COVID-19 is evolving rapidly, given the increasing data from all over the world. In this narrative review, the Turkish Thoracic Society Early Career Taskforce members aimed to provide a summary on recent literature regarding epidemiology, clinical findings, diagnosis, treatment, prevention, and control of COVID-19. Studies revealed that the genetic sequence of the novel coronavirus showed significant identity to SARS-CoV and MERS-CoV. Angiotensin-converting enzyme 2 receptor is an important target of the SARS-CoV-2 while entering an organism. Smokers were more likely to develop the disease and have a higher risk for ICU admission. The mean incubation period was 6.4 days, whereas asymptomatic transmission was reported up to 25 days after infection. Fever and cough were the most common symptoms, and cardiovascular diseases and hypertension were reported to be the most common comorbidities among patients. Clinical manifestations range from asymptomatic and mild disease to severe acute respiratory distress syndrome. Several patients showed typical symptoms and radiological changes with negative RT-PCR but positive IgG and IgM antibodies. Although radiological findings may vary, bilateral, peripherally distributed, ground-glass opacities were typical of COVID-19. Poor prognosis was associated with older age, higher Sequential Organ Failure Assessment score, and high D-dimer level. Chloroquine was found to be effective in reducing viral replication in vitro. Likewise, protease inhibitors, including lopinavir/ritonavir, favipiravir, and nucleoside analogue remdesivir were proposed to be the potential drug candidates in COVID-19 management. Despite these efforts, we still have much to learn regarding the transmission, treatment, and prevention of COVID-19.