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Permanent URI for this collectionhttps://hdl.handle.net/11727/10760

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Subject: search.filters.subject.Allergic rhinitis

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    Immunological Mechanisms of Allergic Rhinitis
    (2021) Koycu, Alper; Yucel, Aysegul Atak; 0000-0003-1290-3509; AAF-3650-2021
    Allergic rhinitis is a specific immunoglobulin (Ig)E-mediated reaction developed against respiratory allergens. The main symptoms of allergic rhinitis; sneezing, runny nose, nasal congestion, itching in the nose, eyes and palate. Cells, cytokines, surface markers, transcription factors and other mediators have been revealed with the sequential removal of nasal biopsy and lavages in human and animal models exposed to allergens over the years. Respiratory allergen induces Th2 lymphocyte proliferation with a combination of cytokines including interleukin (IL)-3, IL-4, IL-5, IL-9, IL-10, and IL-13. These molecules promote allergen specific IgE, mast cells, basophils, eosinophils, adhesion molecules and chemokines. In this review, immunological mechanisms in allergic rhinitis re-examined by reviewing the current literature.
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    Evaluation of the nasal septal body in pediatric patients
    (2021) Coban, Kubra; Ozer, Fulya; Akdogan, M. Volkan; 0000-0001-5381-6861; ABC-1809-2020
    Objective: The nasal septal body (NSB) is a fusiform shaped dynamic structure and the widest part of the anterior septum. It consists of a thickened septal cartilage, bone, glandular, and vasoactive structures covered by mucous membranes. Hence, it plays a role in nasal airflow and humidification. This study evaluated the size of this structure in pediatric patients with allergic rhinitis and other sinonasal pathologies. Methods: The study was conducted at the Baskent University Hospital otolaryngology department between 2015 and 2019. A total of 117 children were enrolled, including 96 patients and 21 controls. The study group was divided into 3 sub-groups: group 1, with sinonasal pathologies and allergic rhinitis; group 2, with sinonasal pathologies only; and group 3, with allergic rhinitis only. The widest horizontal part of the NSB was measured on paranasal coronal computed tomography sections. Results: The mean NSB width in the patient and control groups were 1.00 +/- 0.19 cm and 0.90 +/- 0.16 cm, respectively. The NSB was significantly larger in the patient groups compared to the controls (p=0.032). There was no significant difference among the study sub-groups in terms of NSB width (p=0.215). A significant positive correlation was found between age and NSB in the patient and control groups (r=0.366, p=0.000 and r=0.632, p=0.002, respectively). There was a significant correlation between age and NSB in group 1 and group 2 (r=0.354, p=0.015 and r=0.447, p=0.010, respectively). Conclusion: The nasal septal body is significantly larger in children with comorbid sinonasal pathologies and allergic rhinitis compared to the control group.