Scopus Açık Erişimli Yayınlar

Permanent URI for this collectionhttps://hdl.handle.net/11727/10760

Browse

Filters

2021 - 20223

Settings

Has files: YesSubject: search.filters.subject.biomarker

Search Results

Now showing 1 - 3 of 3
  • No Thumbnail Available
    Item
    Low Pre-Chemoradiotherapy Pan-Immune-Inflammation Value (PIV) Measures Predict Better Survival Outcomes in Locally Advanced Pancreatic Adenocarcinomas
    (2022) Topkan, Erkan; Selek, Ugur; Kucuk, Ahmet; Pehlivan, Berrin; 0000-0001-8120-7123; 0000-0001-8087-3140; 36158517; AAG-2213-2021
    Objective: This study sought to determine whether pretreatment pan-immune-inflammation value (PIV) could be used to predict prognosis in patients with locally advanced pancreatic adenocarcinoma (LA-PAC) following definitive concurrent chemoradiotherapy (C-CRT). Methods: The outcomes of 178 LA-PAC patients who received definitive C-CRT were analyzed retrospectively. For all patients, the PIV was calculated using the peripheral blood platelet (P), monocyte (M), neutrophil (N), and lymphocyte (L) counts obtained on the first day of C-CRT: PIV=PxMxN divided by L. The optimum cutoff values for PIV connected to progression-free (PFS) and overall survival (OS) results were sought using receiver operating characteristic (ROC) curve analysis. The OS and PFS differences between the PIV groups constituted the primary and secondary endpoints, respectively. Results: ROC curve analysis indicated that the ideal PIV cutoff was 464 (AUC: 75.9%, sensitivity: 74.1%, specificity: 71.9%), which categorized patients into two groups based on PFS and OS results: low PIV (L-PIV; N = 69) and high PIV (H-PIV; N = 109). According to comparative survival analyses, patients in the L-PIV group had significantly longer median PFS (14.3 vs 7.3 months; HR: 3.04; P < 0.001) and OS (25.9 vs 13.3 months; HR: 2.86; P < 0.001) than those in the H-PIV group. Although none of the H-PIV patients could survive beyond 5 years, the estimated 5-year OS rate was 29.7% in the L-PIV cohort. In multivariate analyses, besides the L-PIV, N0 nodal stage, and CA 19-9 <= 90 U/mL appeared to be the independent predictors of better PFS (P < 0.05 for each) and OS (P < 0.05 for each) results. Conclusion: The present results indicated that pre-C-CRT L-PIV measures were associated with favorable median and long-term PFS and OS results in LA-PAC patients, suggesting that the PIV is a potent and independent novel prognostic biomarker.
  • No Thumbnail Available
    Item
    Gene Regulatory Network of ETS Domain Transcription Factors in Different Stages of Glioma
    (2021) Babal, Yigit Koray; Kandemir, Basak; Kurnaz, Isil Aksan; 0000-0003-1909-5778; 33671331
    The ETS domain family of transcription factors is involved in a number of biological processes, and is commonly misregulated in various forms of cancer. Using microarray datasets from patients with different grades of glioma, we have analyzed the expression profiles of various ETS genes, and have identified ETV1, ELK3, ETV4, ELF4, and ETV6 as novel biomarkers for the identification of different glioma grades. We have further analyzed the gene regulatory networks of ETS transcription factors and compared them to previous microarray studies, where Elk-1-VP16 or PEA3-VP16 were overexpressed in neuroblastoma cell lines, and we identify unique and common regulatory networks for these ETS proteins.
  • No Thumbnail Available
    Item
    The Role of miRNA in Endometriosis
    (2021) Bilgili, Gamze; Verdi, Hasibe; Zeyneloglu, B. Hulusi; Tohma, Y. Aytac; Atac, F. Belgin
    Endometriosis is characterized by the presence of endometrial gland and stroma outside of the endometrial cavity. Not only the complex nature of disease limits the identification of the pathogenic mechanisms of endometriosis but the lack of simple diagnostic procedure is the major limitation. So identification of a simple clinical tool for the diagnosis of endometriosis has become a high priority research objective. MicroRNAs (miRNAs), a class of small noncoding RNA molecules, have been recognized as key post- transcriptional regulators those may associate with endometriosis. In the present paper, we aimed to review the studies which focused on the prognosis and diagnosis of the endometriosis and miRNAs. As studies on the role of miRNAs in the pathogenesis of endometriosis increase in the literature, new ideas can be put forward for early diagnosis, prevention and treatment of the endometriosis.