PubMed İndeksli Yayınlar Koleksiyonu
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Item A Highly Potent SARS-CoV-2 Blocking Lectin Protein(2022) Ahan, Recep E.; Hanifehnezhad, Alireza; Kehribar, Ebru S.; Oguzoglu, Tuba C.; Foldes, Katalin; Ozcelik, Cemile E.; Filazi, Nazlican; Oztop, Sidika; Palaz, Fahreddin; Onder, Sevgen; Bozkurt, Eray U.; Ergunay, Koray; Ozkul, Aykut; Seker, Urartu Ozgur Safak; https://orcid.org/0000-0001-5653-6080; 35426678; AAJ-7911-2020The COVID-19 (coronavirus disease-19) pandemic affected more than 180 million people around the globe, causing more than five million deaths as of January 2022. SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), the new coronavirus, has been identified as the primary cause of the infection. The number of vaccinated people is increasing; however, prophylactic drugs are highly demanded to ensure secure social contact. A number of drug molecules have been repurposed to fight against SARS-CoV-2, and some of them have been proven to be effective in preventing hospitalization or ICU admissions. Here, we demonstrated griffithsin (GRFT), a lectin protein, to block the entry of SARS-CoV-2 and its variants, Delta and Omicron, into the Vero E6 cell lines and IFNAR(-/-) mouse models by attaching to the spike protein of SARS-CoV-2. Given the current mutation frequency of SARS-CoV-2, we believe that GRFT protein-based drugs will have a high impact in preventing the transmission of both the Wuhan strain as well as any other emerging variants, including Delta and Omicron variants, causing the high-speed spread of COVID-19.Item Insights on Lipomatosis after Platinum-Based Chemotherapy Use in Pediatric Oncology: A Case Report(2022) Boeriu, Estera; Boc, Alexandra Georgiana; Borda, Alexandra; Negrean, Rodica Anamaria; Feciche, Bogdan; Boeriu, Amalia Iulia; Horhat, Florin George; Mot, Ion Cristian; Horhat, Ioana Delia; Ravulapalli, Madhavi; Sabuni, Omar; Adi, Abduljabar; Anjary, Adnan; Arghirescu, Smaranda Teodora; 0000-0002-6147-6518; 36556917Agents of platinum-based chemotherapy, such as cisplatin or carboplatin, are used in the treatment of a wide range of malignancies that affect children, such as brain tumors, osteosarcoma, neuroblastoma, hepatoblastoma, and germ cell tumors (GCTs). The Cyclophosphamide Equivalent Dose (CED) calculator for reproductive risk does not take platinum-based chemotherapy into account, despite the fact that it accounts for the majority of chemotherapy medications that are typically administered for pediatric GCTs. As a result, exposure to platinum-based drugs throughout infancy can have predictable long-term effects such as infertility, as well as other rare encounters such as lipoma formation and lipomatosis. Lipomas are the most prevalent benign soft tissue tumor subtype. They may be either solitary entities or engaged in multiple lipomatosis, which may have a familial origin or be an acquired disorder. Chemotherapy is a possible cause of lipomatosis. Chemotherapy based on cisplatin has been linked to a variety of long-term consequences, including kidney damage, neurotoxicity, and pulmonary toxicity, and may even create secondary cancers. However, lipoma development is known to occur in fewer than 1 in 100 individuals, and only a few examples of multiple cutaneous lipomatosis triggered by this therapy have been documented. Here we present a very rare case of lipomatosis in a pediatric patient with GCT under cisplatin therapy, which might be the third report of this kind affecting children.Item Can CT Pelvimetry Be Used to Predict Circumferential Resection Margin Positivity in Laparoscopic Resection of Middle and Lower Rectum Cancer?(2022) Gojayev, Afig; Yuksel, Cemil; Akbulut, Serkan; Ersen, Ogun; Bakirarar, Batuhan; Gulpinar, Basak; Coruh, Aysegul Gursoy; Unal, Ali Ekrem; Demirci, Salim; 36569682Background Previous studies have shown that pelvimetry can be valuable in predicting surgical difficulties in rectal cancer operations. However, its usability in predicting circumferential resection margin (CRM) involvement remains debatable. This study investigated the factors affecting CRM status and the importance of computed tomography (CT) pelvimetry in predicting CRM involvement in laparoscopic resection of middle and lower rectal cancer.Methodology In this study, we retrospectively investigated the data of 111 patients who underwent a laparoscopic operation for middle and lower rectum cancer at Ankara University Faculty of Medicine, Department of Surgical Oncology between January 2014 and January 2020. The predictive value of CT pelvimetry and other variables on the CRM status was analyzed.Results The following four pelvic parameters differed significantly between the genders: transverse diameter of the pelvic inlet (p = 0.024), anteroposterior diameter of the pelvic outlet (p = 0.003), transverse diameter of the pelvic outlet (p < 0.001), and pelvic depth (p < 0.001). The effect of pelvic anatomic parameters on CRM involvement was not found to be significant. It was found that tumor height from the anal verge (p = 0.004), tumor size (p < 0.001), and gender (p = 0.033) were significant risk factors for CRM involvement. Survival was poor in patients with male gender (p = 0.032), perineural invasion (p < 0.001), and grade 3 tumor.Conclusions In this study, no benefit was found in predicting CRM positivity from CT pelvimetry in the laparoscopic resection of middle and lower rectal cancer. Besides, tumor height from the anal verge, tumor size, and gender were important factors for CRM positivity. Although our study sheds light on this issue, prospective randomized studies with larger sample sizes are needed.Item Pediatric T-cell Lymphoblastic Leukemia/Lymphoma Diagnosed at Routine Adenoidectomy Specimen(2023) Kara, Iike; Ramadan, Saime; Senkal, Evrim; Kocdor, Pelin; 36476077Postoperative routine pathologic evaluation of tonsillectomy and adenoidectomy specimens rarely reveals a diagnosis of malignancy. The object of this case report is to highlight this rare clinical occurrence. A 4-year-old boy presented with symptoms of sleep-disordered breathing and had a history of recurrent tonsillitis. Physical examination revealed adenoid hypertrophy and Brodsky Grade 1 bilateral tonsillar hypertrophy. The patient underwent adenoidectomy and tonsillectomy. The adenoids were found to be MAGS Grade 4 (Modified Adenoid Grading System) hypertrophic causing 100% obstruction. After the histologic examination, T-cell lymphoblastic leukemia/lymphoma was diagnosed. Proper treatment allowed full recovery. Currently, no consensus has been made about routine pathological evaluation. To achieve a cost-effective and precautionary approach, we recommend pathological follow-up of cases with unusual intraoperative findings with/without clinical malignancy suspicion.Item Metagenomics Next Generation Sequencing (mNGS): An Exciting Tool for Early and Accurate Diagnostic of Fungal Pathogens in Plants(2022) Gokdemir, Fatma Seyma; Iseri, Ozlem Darcansoy; Sharma, Abhishek; Achar, Premila N.; Eyidogan, Fusun; https://orcid.org/0000-0003-2951-848X; 36422016Crop output is directly impacted by infections, with fungi as the major plant pathogens, making accurate diagnosis of these threats crucial. Developing technology and multidisciplinary approaches are turning to genomic analyses in addition to traditional culture methods in diagnostics of fungal plant pathogens. The metagenomic next-generation sequencing (mNGS) method is preferred for genotyping identification of organisms, identification at the species level, illumination of metabolic pathways, and determination of microbiota. Moreover, the data obtained so far show that this new approach is promising as an emerging new trend in fungal disease detection. Another approach covered by mNGS technologies, known as metabarcoding, enables use of specific markers specific to a genetic region and allows for genotypic identification by facilitating the sequencing of certain regions. Although the core concept of mNGS remains constant across applications, the specific sequencing methods and bioinformatics tools used to analyze the data differ. In this review, we focus on how mNGS technology, including metabarcoding, is applied for detecting fungal pathogens and its promising developments for the future.Item Clinical Effectiveness Of Buccally And Palatally Anchored Maxillary Molar Distalization: The Miniscrew-Supported 3-Dimensional Maxillary Bimetric Distalizing Arch Vs The Beneslider(2022) Tuncer, Nilufer Irem; Arman-Ozcirpici, Ayca; 36457217Introduction: This study aimed to investigate the dentoalveolar and skeletal changes achieved with a novel miniscrew-supported 3-dimensional maxillary bimetric distalizing arch (3D-MBDA) and the Beneslider. In addition, the study aimed to compare these changes between each other and with an untreated control group. Methods: Sixty-five patients with bilateral Class II molar relationship and fully-erupted maxillary second molars were included in the study. Of these patients, 23 received the miniscrew-supported 3D-MBDA (group 1), 21 received the Beneslider (group 2), and 21 served as untreated control subjects (group 3). Lateral cephalometric films and dental casts, taken at the beginning and the end of maxillary molar distalization, were analyzed to study the differences between the groups. Results: The crown distalization of the first molars was similar between the treatment groups (group 1, 3.1 mm; group 2, 3.3 mm); however, root distalization was significantly more in group 1 (5 mm) when compared with group 2 (1.7 mm). The first molars tipped 6.2 degrees in the mesial direction in group 1 and 8.2 degrees in the distal direction in group 2. The mesiobuccal cusp tip of the first molars extruded for 1.2 mm and increased vertical dimensions in group 2, whereas it intruded for 1.7 mm in group 1. Meanwhile, aforementioned parameters presented insignificant changes throughout the observation period in the control group. Inter-first molar width increased significantly in group 2 (2.7 mm). Distalization time was similar between the groups (group 1, 14 months; group 2, 15 months). The distalization rate was higher in group 2 (0.27 mm/mo) than in group 1 (0.23 mm/mo) measured from the crowns; however, it was similar between the groups (group 1, 0.25 mm/mo; group 2, 0.19 mm/mo) when measured from the trifurcation point. Conclusions: The miniscrew-supported 3D-MBDA was more effective in distalizing molar roots and maintaining vertical parameters and dental arch width while tipping the molars mesially. In contrast, the Beneslider distalized molar crowns faster, resulting in significant distal tipping. (Am J Orthod Dentofacial Orthop 2022;162:e337-e348)Item Letter To Editor in Regard to Recent Published Study of Abed Et Al. Titled 'The Association Between Dental Arch Length And Oral Health-Related Quality of Life in Head And Neck Cancer Patients Post-Radiotherapy'(2023) Yilmaz, Busra; Somay, Efsun; https://orcid.org/0000-0003-0633-5648; 36222114Item The association of antiviral drugs with COVID-19 morbidity: The retrospective analysis of a nationwide COVID-19 cohort(2022) Eyuboglu, Fusun Oner; 0000-0002-5525-8207; 36117966; AAR-4338-2020Background and objectivesAlthough several repurposed antiviral drugs have been used for the treatment of COVID-19, only a few such as remdesivir and molnupiravir have shown promising effects. The objectives of our study were to investigate the association of repurposed antiviral drugs with COVID-19 morbidity. MethodsPatients admitted to 26 different hospitals located in 16 different provinces between March 11-July 18, 2020, were enrolled. Case definition was based on WHO criteria. Patients were managed according to the guidelines by Scientific Board of Ministry of Health of Turkey. Primary outcomes were length of hospitalization, intensive care unit (ICU) requirement, and intubation. ResultsWe retrospectively evaluated 1,472 COVID-19 adult patients; 57.1% were men (mean age = 51.9 +/- 17.7years). A total of 210 (14.3%) had severe pneumonia, 115 (7.8%) were admitted to ICUs, and 69 (4.7%) were intubated during hospitalization. The median (interquartile range) of duration of hospitalization, including ICU admission, was 7 (5-12) days. Favipiravir (n = 328), lopinavir/ritonavir (n = 55), and oseltamivir (n = 761) were administered as antiviral agents, and hydroxychloroquine (HCQ, n = 1,382) and azithromycin (n = 738) were used for their immunomodulatory activity. Lopinavir/ritonavir (beta [95% CI]: 4.71 [2.31-7.11]; p = 0.001), favipiravir (beta [95% CI]: 3.55 [2.56-4.55]; p = 0.001) and HCQ (beta [95% CI]: 0.84 [0.02-1.67]; p = 0.046) were associated with increased risk of lengthy hospital stays. Furthermore, favipiravir was associated with increased risks of ICU admission (OR [95% CI]: 3.02 [1.70-5.35]; p = 0.001) and invasive mechanical ventilation requirement (OR [95% CI]: 2.94 [1.28-6.75]; p = 0.011). ConclusionOur findings demonstrated that antiviral drugs including lopinavir, ritonavir, and favipiravir were associated with negative clinical outcomes such as increased risks for lengthy hospital stay, ICU admission, and invasive mechanical ventilation requirement. Therefore, repurposing such agents without proven clinical evidence might not be the best approach for COVID-19 treatment.Item Left atrial deformations: So clinically relevant(2022) Donal, Erwan; Sade, L. Elif; Kosmala, Wojciech; 35662559Item Prediction of disability in trigger finger: a cross-sectional and longitudinal study(2023) Namaldi, Seda; Kuru, Cigdem Ayhan; Kuru, Ilhami; 36324191The aim of this prospective study of 55 patients was to analyse the cross-sectional and longitudinal relationship between disability and physical and psychological variables after conservative treatment of trigger finger and to determine the predictive factors for the post-treatment disability score and change in disability score. The primary outcome measure was the Disabilities of the Arm, Shoulder, and Hand questionnaire. Potential predictive factors included pain, number of triggering events, depression, anxiety and kinesiophobia. Disability correlated strongly with anxiety, moderately with pain and depression and weakly with triggering and kinesiophobia. The change in depression score correlated significantly with the change in disability score. Post-treatment pain and anxiety scores accounted for 47% of the explained variance in disability score. Improvement in depression after treatment accounted for 18% of the explained variance in disability change score. Psychological variables appear to be potential predictors of disability.