PubMed İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/11727/4810
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Item Comparison of no adjuvant treatment and radiotherapy in early-stage cervical carcinoma with intermediate risk factors(2020) Akilli, Huseyin; Tohma, Yusuf A.; Bulut, Ayca N.; Karakas, Latife Atasoy; Haberal, Asuman N.; Kuscu, Ulku E.; Ayhan, Ali; 0000-0002-5240-8441; 0000-0001-7369-5470; 0000-0002-0992-6980; 0000-0001-9418-4733; 0000-0001-9852-9911; 32246761; AAX-3230-2020; AAI-8793-2021; AAI-8792-2021; AAE-6482-2021; AAK-4587-2021; AAJ-5802-2021Objective To evaluate the results of receiving no adjuvant treatment (NAT) or radiotherapy after radical hysterectomy in patients with International Federation of Gynecology and Obstetrics 2018 Stage IB1-IB3 cervical cancer with intermediate risk factors. Methods A retrospective cohort study was conducted at Baskent University School of Medicine's Department of Gynecology and Obstetrics in Ankara, Turkey between January 1, 2008, and December 31, 2016. In total, 134 women with at least two intermediate risk factors (positive LVSI, deep stromal invasion, and tumor size >= 4 cm) were included in the study. Patients were divided into two groups: NAT and radiotherapy. Results There were 66 patients in the NAT group and 68 in the radiotherapy group. The median follow-up time was 61.05 months. The 5-year overall survival (OS) rates were similar in both groups (84.1% vs 82.9%, respectively; P=0.57), while the 5-year disease-free survival (DFS) rates were 80.2% and 78.2% in the NAT and radiotherapy groups, respectively (P=0.25). Most importantly, both groups had similar local recurrence rates: 8 (12.1%) in the NAT group and 9 (13.2%) in the radiotherapy group (P=0.82). Multivariant analyses showed that the only independent risk factor for recurrence was tumor size >= 4 cm with a hazard ratio of 2.4 (95% confidence interval 1.12-5.24; P=0.02). Conclusion Adjuvant treatment improved neither DFS nor local recurrence rates.Item Nulliparity and postmenopausal status are independent factors of malignancy potential of endometrial intraepithelial neoplasia in polyps(2020) Karakas, Latife Atasoy; Atilgan, Alev Ok; Akilli, Huseyin; Kuscu, Ulku Esra; Haberal, Ali; Ayhan, Ali; 0000-0001-8595-8880; 0000-0002-0992-6980; 0000-0001-7369-5470; 0000-0002-1486-7209; 33118172; AAK-3333-2021; AAI-8792-2021; AAI-8793-2021; AAI-9331-2021; AAX-3230-2020; AAJ-5802-2021Objective To estimate the risk of concurrent endometrial cancer in endometrium when endometrial intraepithelial neoplasia (EIN) is found within an endometrial polyp and to identify the possible predictive factors for concurrent endometrial cancer. Methods Histopathologic data of women who underwent hysteroscopy for resection of endometrial polyps at Ankara Baskent University Hospital, between 2011 and 2019 were screened. Patients whose polypectomy report was EIN in a polyp, and who had a final report of the hysterectomy specimen were included. Patients were divided into two groups according to the presence of concurrent cancer in the hysterectomy material: group 1, concurrent cancer present and group 2, concurrent cancer absent. Statistical analyses were performed using SPSS. Results A total of 4125 women underwent hysteroscopy for the resection of endometrial polyps. Of those women, 161 (3.9%) were diagnosed as having EIN and 115 met the criteria. The rate of concurrent endometrial cancer was 28.6% (33/115). According to multivariate analysis, nulliparity (odds ratio [OR] 0.38; 95% confidence interval [CI] 1.04-3.67; p = 0.036) and postmenopausal status (OR 0.64; 95% CI 0.42-0.98; p = 0.042) were found to be independent factors significantly associated with concurrent endometrial cancer. Conclusion The incidence of concurrent cancer is higher in postmenopausal or nulliparous women when EIN is detected in a polyp.