PubMed Kapalı Erişimli Yayınlar
Permanent URI for this collectionhttps://hdl.handle.net/11727/10764
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Item The effects of catechol-O-methyltransferase single nucleotide polymorphisms on positive and negative symptoms of schizophrenia: A systematic review and meta-analysis(2022) Misir, Emre; Ozbek, Mutlu Muhammed; Halac, Eren; Turan, Serkan; Alkas, Gokce Elif; Ciray, Remzi Ogulcan; Ermis, Cagatay; 0000-0001-8953-1171; 35642295; AAF-3209-2021The catechol-O-methyltransferase (COMT) gene is thought to have an important role in the etiopathogenesis of schizophrenia, but there are conflicting results regarding its role in clinical presentation. We aimed to elucidate the relationship between the single nucleotide polymorphisms (SNPs) in the COMT gene and the severity of positive and negative symptoms. In order to investigate the relationship, the PubMed, PubMed Central, Scopus, and Cochrane CENTRAL databases were screened for eligible articles. Thirty-eight studies, including 4443 adult patients with schizophrenia, were included in the quantitative analyses, and four studies were qualitatively assessed. Quantitative analyses were performed for acutely ill and clinically stable patient subgroups regarding the different genotypes of rs4680 SNP. Our results showed that the severity of negative symptoms was higher in patients who were rs4680 Met homozygous compared to Val/Met heterozygotes only in acutely ill samples. There was no other significant difference between genotypes. Meta-regression did not reveal any significant moderator effect on the difference in negative symptoms. General psychopathology, positive, negative, and total psychotic symptom levels also were similar between Val homozygotes and Met carriers. Nonetheless, there are some limitations in the study. First, SNPs except for rs4680 were under-researched because of the limited number of studies. Second, high heterogeneity across studies was the main concern. Our results suggested that the COMT rs4680 Met allele was associated with higher levels of negative symptoms within acutely ill patients. Future studies should focus on specific patient subgroups to reveal the moderating effects of SNPs.Item 'Ilie effects of working and living conditions of physicians on burnout level and sleep quality(2021) Misir, Emre; 34726667Background: Burnout is a multidimensional syndrome associated with intense working conditions and negative psychosocial factors in physicians. The purpose of this study is to investigate the effects of living and working con-ditions of physicians on burnout level and sleep quality in Turkey. Metbods: In this internet-based questionnaire study, 1053 physicians [General Practitioners (n=233); Basic Medical Sciences (n=26); Internal Medical Sciences (n=530), and Surgery Sciences (n=264)J were included in the study, filling the forms consisting of study conditions, Maslach Burnout Inventory (MBI) and the Pittsburgh Sleep Quality Index (PSQI) questions. Results: Negative occupational factors such as physicians having a night shift, high number of patients who are cared for daily, short ex-amination period, low financial gain, exposure to violence, and mobbing were associated with poor sleep quality and burnout. Factors such as being subjected to violence, mobbing, and age are predictive of increasing burnout in women. Working on night shifts or being on-call were associated with all aspects of burnout. The proportion of those with poor sleep quality was significantly higher in those working night shifts (74.6%) than those working daytime shifts (67.2%) and those who were exposed to violence (75.1%) compared to those who were not exposed to violence (43.2%) (p=0.013, p<0.001, respectively). Conclusions: Impaired sleep quality, violence, mobbing, young age, excessive night shifts, short examination period, and low income may play a role in physician burnout. Our study data suggest that it is important to improve physicians' unfavorable working conditions and to prevent violence against burnout.