PubMed Kapalı Erişimli Yayınlar
Permanent URI for this collectionhttps://hdl.handle.net/11727/10764
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Item Prospective randomized controlled study of a microfluidic chip technology for sperm selection in male infertility patients(2022) Aydin, Sirin; Bulgan Kilicdag, Esra; Caglar Aytac, Pinar; Cok, Tayfun; Simsek, Erhan; Haydardedeoglu, Bulent; https://orcid.org/0000-0001-6176-925X; 35263457; ADR-0014-2022The purpose of this study is to evaluate the impact of a microfluidic approach for spermatozoon selection in male infertility patients undergoing intracytoplasmic sperm injection (ICSI). This research enrolled 128 individuals who had ICSI for male-factor infertility. The patients were separated into two groups according to the method used to pick the spermatozoa: group I (n = 64), which used traditional swim-up procedures, and group II (n = 64), which used the Fertile Chip for spermatozoon selection during ICSI therapy. Fertilization rates and embryo quality were the major outcomes. The rates of pregnancy, clinical pregnancy and live birth were used as secondary outcomes. As a result, there was no statistically significant difference between the two groups in terms of fertilization rate, total grade 1 and 2 embryos. Implantation rate was significantly higher in the Fertile Chip group than in the control group (50% vs. 31%, p = 0.02). The Fertile Chip group had considerably greater pregnancy rates, clinical pregnancy rates (CPR) and live birth rates than the control group (62.5% vs. 45.3%, p = 0.038; 59.4% vs. 35.9%, p = 0.006 and 46.8% vs. 25%, p = 0.009). Fertile Chip had no effect on fertilization rates or embryo quality in male-factor infertility couples. However, the Fertile Chip group had a statistically higher pregnancy rate, CPR and live birth rate.Item Single- or double-layer uterine closure techniques following cesarean: A randomized trial(2020) Yilmaz Baran, Safak; Kalayci, Hakan; Dogan Durdag, Gulsen; Yetkinel, Selcuk; Alemdaroglu, Songul; Cok, Tayfun; Bulgan Kilicdag, Esra; 0000-0002-5064-5267; 0000-0002-2165-9168; 0000-0003-4335-6659; 0000-0002-0942-9108; 0000-0002-7854-2921; 0000-0001-5874-7324; 33029804; AAI-9594-2021; AAL-1530-2021; AAI-8400-2021; AAK-8872-2021; A-8208-2008; ABF-6439-2020Introduction Cesarean deliveries are commonly performed throughout the world. Although the uterine closure technique following this procedure may influence how the uterine scar heals, there is insufficient evidence for choosing the appropriate technique and so preventing long-term negative consequences. This prospective, randomized study examined the effects of single- and double-layer uterine closure techniques on uterine scar healing following cesarean delivery. Material and methods This study assessed a total of 282 women aged 18-45 years who were in gestational weeks 24-41 of singleton pregnancies. None had previously undergone uterine surgeries. These participants completed their first cesarean deliveries at the time of study and were randomized into the following two treatment groups: single-layer closure with locking and double-layer closure with locking in the first layer, but not in the second layer (NCT03629028). However, the decidua was not included for treatment in either group. Participants were evaluated at 6-9 months after cesarean section by saline infusion sonohysterography to assess cesarean delivery scar defects. These procedures were conducted by experienced sonographers who were not aware of the uterine closure technique. Results Of the 225 final participants, 109 received the single-layer closure technique, whereas 116 received the double-layer technique. The niche rates were 37% (n = 40) for the single-layer group and 45.7% (n = 53) for the double-layer group (P = .22, relative risk 1.4, 95% CI = 0.8-4.4). Conclusions The single- and double-layer closure techniques did not produce different impacts on uterine scar niche development.