Scopus Kapalı Erişimli Yayınlar

Permanent URI for this collectionhttps://hdl.handle.net/11727/10761

Browse

Filters

2020 - 20233

Settings

Author: search.filters.author.Alptekin, Nilgun Ozlemsearch.filters.applied.f.rights: search.filters.rights.info:eu-repo/semantics/closedAccess

Search Results

Now showing 1 - 3 of 3
  • No Thumbnail Available
    Item
    Peri-Implant Crevicular Fluid And Serum Levels Of Soluble ST2 In Peri-Implant Diseases: A Pilot Study
    (2023) Ozgur, Engin; Topcu, Deniz Ilhan; Bayraktar, Nilufer; Alptekin, Nilgun Ozlem; https://orcid.org/0000-0002-7911-198X; https://orcid.org/0000-0002-1219-6368; https://orcid.org/0000-0002-7886-3688; https://orcid.org/0000-0003-4104-6462; 36504319; E-3717-2019; Y-8758-2018; G-1816-2014
    Background and ObjectiveSoluble ST2 (sST2) is a current biomarker of cardiovascular disease. It is used to predict susceptibility to cardiovascular diseases and to analyze their prognosis. Serum sST2 level increases in inflammatory diseases such as periodontitis. However, the level of sST2 in peri-implant diseases and crevicular fluid has not been investigated yet. Thus, the aim of this cross-sectional study is to analyze the level of sST2 in peri-implant health and diseases. MethodsSixty-nine participants were divided into 3 groups as peri-implant health (PH), peri-implant mucositis (PM), and peri-implantitis (P-I). Peri-implant crevicular fluid (PICF) and serum samples were collected from each participant. The levels of sST2 and IL-6 in PICF and sST2, IL-6, and CRP in serum were compared between the groups. Pocket depth (PD), modified bleeding index (mBI), modified plaque index (mPI), keratinized mucosa index (KTW), and gingival/mucosal recession (REC) were recorded as clinical parameters. Biomarkers in the serum and PICF were analyzed by ELISA kit. ResultsSixty-nine patients were included in the study. The differences in the following parameters were statistically significant between groups: age (p = .009), implant function time (p = .027), PD (p < .001), mBI (p < .001), mPI (p < .001), and KTW (p = .043). The PICF volume of P-I and PM groups were statistically higher than PH (p < .001). The amount of sST2 in P-I and PM groups were higher than PH (p = .043). Serum CRP was higher in the P-I group than in other groups (p = .034). There were no significant differences in serum sST2 (p = .247) and IL-6 (p = .110) levels between groups. ConclusionThe PICF levels of sST2 were significantly higher in PM and P-I groups compared to the healthy group. However, no significant difference was observed between the groups in terms of serum sST2 level.
  • No Thumbnail Available
    Item
    The Effects of Non-Surgical Periodontal Therapy on Neutrophil Elastase and Elastase Alpha-1 Proteinase Inhibitor Levels in GCF in Periodontitis Patients with or Without Acute Coronary Syndrome
    (2021) Kayar, Nezahat Arzu; Ustun, Kemal; Gozlu, Muammer; Haliloglu, Seyfullah; Alptekin, Nilgun Ozlem; 33687554
    Objective Periodontitis may contribute to vascular damage, resulting in the destabilization of atherosclerotic plaque leading to acute coronary syndrome (ACS). In this study, we explored the effect of non-surgical periodontal treatment (NSPT) on cardiovascular blood biomarkers and gingival crevicular fluid (GCF) neutrophil elastase (NE) and alpha 1-proteinase inhibitor (alpha-1PI) levels in periodontitis (P) participants with and without ACS. Materials and methods Medical and dental examinations were performed to diagnose ACS and periodontitis, respectively. Seventeen patients with diagnosis of ACS and periodontitis were included in this study, as a test group (group ACS). Twenty-six age and sex-matched control patients with periodontitis (group P) were otherwise systemically healthy. Both groups received NSPT. Plasma levels of cholesterol, triglyceride, high-density lipoprotein (HDL), low-density lipoprotein (LDL), C-reactive protein (CRP), GCF NE activity, GCF alpha(1)-PI levels, and GCF NE/alpha 1-PI rates were measured at baseline, at1(st) and 3(rd) months after NSPT. Results GCF NE activity/time (mu U/30s) decreased significantly at 3(rd) month compared to baseline values in the Group P after NSPT. First and 3(rd) months after NSPT, in the Group P GCF alpha(1)-PI activity/time (pg/30s) was significantly higher than the Group ACS. Moreover GCF NE/alpha(1)-PI rates decreased significantly compared to baseline values at 1(st) and 3(rd) months after NSPT in the group P. Conclusion NSPT yields decrease in NE/alpha(1)-PI rates. NE and its possible interactions with alpha(1)-PI may play a crucial role in both periodontitis and ACS. GCF alpha 1PI activity/time (U/30s) can be a potential biomarker in management of periodontitis associated with ACS.
  • No Thumbnail Available
    Item
    Immune responses in women with periodontitis and preterm low birth weight: Levels of CD4+and CD8+T cells in gingival granulation tissue
    (2020) Kayar, Nezahat Arzu; Celik, Ilhami; Alptekin, Nilgun Ozlem; 0000-0003-4104-6462; 31542704; G-1816-2014
    Objective: Preterm Low-Birth-Weight (PLBW) is frequently associated with periodontal disease. However, the mechanism is still unknown. The present study was performed to examine the possible link between periodontal infections and PLBW in post-partum women utilizing clinical parameters and CD4+ and CD8 + T lymphocytes ratio in gingival granulation tissue. Materials: The tissues used in this study consisted of 35 gingival granulation tissue biopsies from 35 mothers of healthy infants (HTBW), 35 biopsies of gingival granulation tissue from 35 mothers of PLBW within one month postpartum and gingival tissue biopsies from 7 control individual with no periodontal disease (HC). CD4 + and CD8 + T lymphocyte ratios in a unit area of the gingival granulation tissue were determined by hystometrically. Statistical analysis was performed by using Kruskal-Wallis and Mann-Whitney U tests. Results: CD8 + T lymphocytes were more prevalent in the PLBW group than in the HTBW and HC group (P < 0.05). The CD4 + /CD8 + ratio in the PLBW group was lower than those of the other groups (p < 0.05). There were no statistically significant differences in CD4 + T lymphocytes counts between all groups (P > 0.05). Conclusion: Within the limits of this study it can be concluded that CD8 + T lymphocytes in gingival tissue may play important roles in the pathogenesis of periodontitis and PLBW.