TR-Dizin Açık Erişimli Yayınlar

Permanent URI for this collectionhttps://hdl.handle.net/11727/10759

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Author: search.filters.author.Kiziltan, Gulsearch.filters.applied.f.language: search.filters.language.eng

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    The Relationship Between Dietary Intakes and Total Kidney Volume in Patients with Autosomal Dominant Polycystic Kidney Disease Dietary Intake and Polycystic Kidney Volume
    (2022) Sevim, Yonca; Cebeci, Egemen; Ozkan, Ozlem Persil; Savas, Yildiray; Ozturk, Savas; Kiziltan, Gul
    Aim: There is a need to understand autosomal dominant polycystic kidney disease (ADPKD) patients' dietary habits since dietary interventions may have potential effects on ADPKD. In this study, we aimed to analyze the relationship between dietary nutrient intake and total kidney volume (TKV).Methods: This cross-sectional study was conducted on 54 ADPKD patients recruited from the Nephrology outpatient clinic between June and July 2014. TKV was determined by magnetic-resonance imaging and general characteristics, biochemical and urinary parameters were determined. The nutrient intakes of patients were calculated using the three-day dietary records obtained on three consecutive days.Results: The total kidney-volume median was found to be 1407 mL. Patients' total dietary energy and protein intakes were 25.8 +/- 9.4 kcal/kg, 0.9 +/- 0.3 g/kg, respectively. The percentage of carbohydrates, protein, and fat in energy was 49 +/- 7%, 14 +/- 3%, 37 +/- 7%, respectively. The mean intakes of thiamin, riboflavin, B6, calcium, magnesium, and zinc were sufficient, the mean dietary potassium intake was insufficient; and sodium intake was excessive in both sexes. In females, there was a negative but weak correlation between dietary vitamin C intake and TKV. In males, a negative but weak correlation was found between TKV and dietary intake of fiber, water, vitamin B6, vitamin K, magnesium, and iron. Conclusions: Dietary micronutrient intake may affect TKV according to sex.
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    The Effect of Probiotic and Omega-3 Supplements on Total Oxidant and Total Antioxidant Levels in Experimental Colitis
    (2021) IIlktac, Havvanur Yoldas; Kiziltan, Gul; Ozansoy, Mehmet; Kilic, Ulkan; Togay, Sine Ozmen; Keskin, Ilknur; Ozdemir, Ekrem Musa; Gunal, Mehmet Yalcin
    Objective: Treatment of inflammatory bowel disease (IBD) usually involves medical therapy. For this reason, it is recommended to seek alternative treatment methods such as nutritional therapy. The aim of the study is to evaluate the effects of probiotics and omega-3 fatty acids on total oxidant and total antioxidant levels in an experimental colitis model. Methods: Mice were randomly divided into five groups (n= 10/group) as healthy group, colitis group, group treated with probiotics (VSL#3), group treated with omega-3 (w-3), and group treated with both probiotics and omega-3. To induce experimental colitis, 200 mg/kg dinitrobenzene sulfonic acid (DNBS) + 30% ethanol combination was rectally administered to anesthetized mice. Total oxidant (TOS) and total antioxidant (TAS) levels were measured at the tissue level. Results: Lower concentrations of TOS were observed in the probiotics groups (2.11 +/- 0.23 mmol H2O2 Eq/L), probiotics+omega-3 (2.56 +/- 1.18 mmol H2O2 Eq/L), and omega-3 (3.02 +/- 1.88 mmol H2O2 Eq/L) groups compared to the colitis group (3.11 +/- 0.91 mmol H2O2 Eq/L) (p>0.05). Higher TOS and TAS level were observed in the control colitis group compared to other groups; however, the differences were not statistically significant. Conclusion: Our findings showed that TAS and TOS levels were positively affected by the use of probiotic supplements in IBD. It was determined that using w-3 alone was ineffective in decreasing TOS levels. Studies with higher dosages and longer treatment periods are needed to better observe the effects of nutritional supplements on TOS and TAS parameters in inflammatory bowel diseases.