Scopus İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/11727/4809

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    The Importance of DHEA-S Levels in Cushing's Syndrome; Is There a Cut-off Value in the Differential Diagnosis?
    (2022) Ciftci, Sema; Soyluk, Ozlem; Selek, Alev; Erol, Selvinaz; Hekimsoy, Zeliha; Esen, Ayse; Dursun, Huseyin; Sahin, Serdar; Oruk, Gonca; Mert, Meral; Soylu, Huseyin; Yurekli, Banu Sarer; Ertorer, Melek Eda; Omma, Tulay; Evran, Mehtap; Adas, Mine; Tanrikulu, Seher; Aydin, Kadriye; Pekkolay, Zafer; Can, Bulent; Karakilic, Ersen; Karaca, Zuleyha; Bilen, Habib; Canturk, Zeynep; Cetinarslan, Berrin; Kadioglu, Pinar; Yarman, Sema; https://orcid.org/0000-0001-7357-8709; 35413744; ABI-3705-2020
    The purpose of this study was to determine possible cut-off levels of basal DHEA-S percentile rank in the differential diagnosis of patients with Cushing's syndrome (CS) with ACTH levels in the gray zone and normal DHEA-S levels. In this retrospective study including 623 pathologically confirmed CS, the DHEA-S percentile rank was calculated in 389 patients with DHEA-S levels within reference interval. The patients were classified as group 1 (n=265 Cushing's disease; CD), group 2 (n=104 adrenal CS) and group 3 (n=20 ectopic ACTH syndrome).ROC-curve analyses were used to calculate the optimal cut-off level of DHEA-S percentile rank in the reference interval in the differential diagnosis of CS, and the effectiveness of this cut-off level in the identification of the accurate etiology of CS was assessed in patients who were in gray zone according to their ACTH levels. The DHEA-S percentile rank in the reference interval were significantly lower in group 2 compared to the other two groups (p<0.001), while group 1 and group 3 had similar levels. The optimal cut-off level of DHEA-S percentile rank in the reference interval providing differential diagnosis between group 1 and group 2 was calculated as 19.5th percentile (80.8% sensitivity, 81.5% specificity) and the level demonstrated the accurate etiology in 100% of CD and 76% of adrenal CS patients who were in the gray zone. This study showed that the cut-off value of DHEA-S level less than 20% of the reference interval could be used for differential diagnosis of CD and adrenal CS with high sensitivity and specificity, and it should be taken into the initial evaluation.
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    High accuracy of recognition of common forms of folliculitis by dermoscopy: An observational study
    (2019) Durdu, Murat; Errichetti, Enzo; Eskiocak, Ali Haydar; Ilkit, Macit; 0000-0003-1247-3932; 30914342; H-9068-2019
    Background: Clinical differentiation of folliculitis types is challenging. Dermoscopy supports the recognition of folliculitis etiology, but its diagnostic accuracy is not known. Objective: To assess the diagnostic accuracy of dermoscopy for folliculitis. Methods: This observational study included patients (N = 240) with folliculitis determined on the basis of clinical and dermoscopic assessments. A dermoscopic image of the most representative lesion was acquired for each patient. Etiology was determined on the basis of cytologic examination, culture, histologic examination, or manual hair removal (when ingrowing hair was detected) by dermatologist A. Dermoscopic images were evaluated according to predefined diagnostic criteria by dermatologist B, who was blinded to the clinical findings. Dermoscopic and definitive diagnoses were compared by dermatologist C. Results: Of the 240 folliculitis lesions examined, 90% were infections and 10% were noninfectious. Infectious folliculitis was caused by parasites (n = 71), fungi (n = 81), bacteria (n = 57), or 7 viruses (n = 7). Noninfectious folliculitis included pseudofolliculitis (n = 14), folliculitis decalvans (n = 7), and eosinophilic folliculitis (n = 3). The overall accuracy of dermoscopy was 73.7%. Dermoscopy showed good diagnostic accuracy for Demodex (88.1%), scabietic (89.7%), and dermatophytic folliculitis (100%), as well as for pseudofolliculitis (92.8%). Limitations: The diagnostic value of dermoscopy was calculated only for common folliculitis. Diagnostic reliability could not be calculated. Conclusion: Dermoscopy is a useful tool for assisting in the diagnosis of some forms of folliculitis.