Scopus İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/11727/4809

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    Radiographic Ischial Enthesopathy in Patients with Psoriatic Arthritis
    (2022) Bitik, Berivan; Dalgic, Gunay Sahin; Kanbur, Aysenur Yalcintas; Ok, Mehtap Akcil; Yucel, Ahmet Eftal; https://orcid.org/0000-0001-5803-915X; AAI-9195-2021
    Background To investigate the prevalence of radiographic ischial entheseal lesions in patients with psoriatic arthritis (PsA) compared to patients with rheumatoid arthritis (RA). Patients and Methods Thirty-eight patients with PsA and 46 patients with RA were included. Anteroposterior radiographs of the pelvis and lateral foot were evaluated for entheseal lesions. The following entheseal sites were reviewed: os ischium, bilateral Achilles tendon and inferior calcaneus. Abnormalities such as cortical erosions and enthesophytes (irregular bony proliferation) were recorded. Results The frequency of enthesopathic changes in the ischial region was found to be statistically significantly higher in PsA patients compared with RA patients (50 and 28.3%, respectively, p=0.04). Enthesopathic changes of the calcaneus and Achilles tendon also occurred more frequently in PsA patients than in RA patients. Conclusion Radiographic entheseal lesions in the ischial region are more prevalent in PsA patients compared with RA patients with symptoms in that region. Furthermore, such enthesopathic changes in the ischium are observed as frequently as changes in the Achilles tendon. These findings regarding structural entheseal lesions in the pelvic region contribute to the knowledge of entheseal involvement in PsA.
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    The effectiveness of intra-articular bleomycin versus methotrexate in a chronic synovitis model
    (2020) Maralcan, Gokhan; Inan, Ulukan; Kuru, Ilhami; Aktepe, Fatma; Isik, Cengiz; 0000-0002-1268-1451; AAJ-4341-2021
    Objective: To compare the effectiveness of methotrexate which was proven to be effective for rheumatoid arthritis and bleomycin in a synovitis model. Our aim was to show whether bleomycin could be used for chemical synovectomy purposes. Design: Experimental study Setting: Department of Orthopedics and Traumatology, Faculty of Medicine, Afyon Kocatepe University, Afyon, Turkey Subjects: Fifteen mature New Zealand rabbits were studied. Synovitis was induced by repeated injections of lambda carrageenan. Interventions: Knees of the subjects were grouped as sham, bleomycin and methotrexate. After synovitis occurred, sterile saline injected knees formed the sham group, bleomycin and methotrexate injected knees composed the study groups. In the 9th week of the study, animals were euthanised. Standard specimens were harvested from all knees. Immunoperoxidase staining was performed. Main outcome measures: The intensity of synovitis was evaluated with thickness of the synovial cell layers, intensity of inflammatory infiltrate and iNOS expression in cells. Results: Thickness of the synovial cell layers was greater in the sham group than in the study groups (p<0.05). Intensity of inflammatory infiltrate, lymphoplasmacytoid infiltrate, and histiocytes in the sham group were greater than in the study groups (p<0.05). iNOS expression in histocytes and plasma cells was significantly decreased in the study groups compared to sham operated group (p<0.05). There was no statistically significant difference between bleomycin and methotrexate groups with respect to synovial cell layer thickness and lymphoplasmacytoid infiltrate. Conclusions: According to these results, intraarticular bleomycin seems as effective as methotrexate in experimental synovitis model.