Scopus İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/11727/4809

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    Comparison of Epicardial Fat, Carotid and Femoral Intima-Media Thicknesses Between Hypertensive, Pre-Hypertensive and Control Groups
    (2020) Gunesli, Aylin; Yilmaz, Mustafa; 0000-0002-2557-9579; S-6973-2016
    Objective: The aim of this study was to evaluate whether pre-hypertension is a risk factor for cardiovascular events. For this reason epicardial fat thickness (EFT), carotid intima-media thickness (CIMT) and femoral intima-media thickness (FIMT), known as markers for subclinical atherosclerosis and cardiovascular risks were measured and compared among the pre-hypertensive, hypertensive and control groups. Material and methods: This cross-sectional study included 57 healthy controls (group 1), 58 pre-hypertensive patients (group 2) and 56 hypertensive patients (group 3). Pre-hypertension is defined as systolic blood pressure (SBP) 120-140 mm Hg and diastolic blood pressure (DBP) 80-90 mm Hg. Hypertension is defined as SBP>140 mm Hg and/or DBP>90 mm Hg. EFT, CIMT and FIMT were measured and compared among these groups. Results: There was a statistically significant difference among the groups in terms of EFT and CIMT (p<0.001, for both comparison). In addition there was a statistically significant difference between groups 2 and 1, and between groups 3 and 2 in terms of EFT and CIMT (p<0.001, for all comparisons). When we compared the all groups in terms of FIMT, we found a statistically significant difference (p<0.001). There was a statistically significant difference between groups 3 and 2 (p=0.001). However, there was not a statistically significant difference between groups 2 and 1 (p=0.773). Conclusion: These results may indirectly suggest that subclinical atherosclerosis and cardiovascular risks may be increased in pre-hypertensive patients. However, atherosclerosis in the carotid arteries may be affected by lower blood pressure than the femoral arteries.
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    Assessment of Subclinical Atherosclerosis in Vitamin D Deficiency
    (2019) Aydin, Elcin; Altin, Cihan; Soylev, Gozde Ozcan; Tekindal, Mustafa Agah; Agildere, Muhtesem; 30300321; AAB-5802-2020
    Purpose Patients with vitamin D deficiency (VDD) have potential to have increased cardiovascular morbidity and mortality. In this study, we aimed to discover the findings of early atherosclerosis in patients with VDD by measuring carotid intima-media thickness (CIMT) and epicardial fat thickness (EFT). Materials and Methods The study population includes 52 patients with VDD (n = 30 [57% female], mean +/- SD age 54.28 +/- 8.77 years, mean +/- SD serum 25-hydroxyvitamin D (25 [OH] D) 11 +/- 2.4 ng/mL) and 82 participants for control group (n = 52 [63.4% female], mean +/- SD age 56.40 +/- 7.90 years, mean +/- SD serum (25 [OH] D) 53 +/- 4.2 ng/mL) who have no cardiovascular disease. Carotid intima-media thickness was assessed by using ultrasonography, and EFT was measured on the free wall of the right ventricle at end diastole from the parasternal long-axis views by standard transthoracic 2-dimensional echocardiography. Results Both CIMT and EFT were significantly higher in patients with VDD compared with controls (0.75 +/- 0.16 mm vs 0.68 +/- 0.21 mm, P < 0.05, and 0.66 +/- 0.15 cm vs 0.56 +/- 0.15 cm, P < 0.001). Conclusions Patients with VDD seem to have increased CIMT and EFT, which are predictors of atherosclerotic process. Further studies are needed to confirm these results.
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    Parathyroid Hormone and Ischemic Cerebrovascular Event
    (2019) Altay, Hakan; Altin, Cihan; Coner, Ali; Muderrisoglu, Haldun; Giray, Semih; 0000-0002-9635-6313; 0000-0002-0722-3181; 30806331; AAG-8233-2020; AAH-1091-2020
    Background: Increased parathyroid hormone (PTH) level is associated with coronary artery disease, hypertension and left ventricular hypertrophy which are all predisposing factors for the ischemic cerebrovascular event ( ICVE). Carotid intima-media thickness (CIMT) and aortic distensibility are the two early, subclinical predictors of atherosclerosis. The relation of PTH with CIMT and aortic distensibility in patients with ICVE has not been previously studied. Objective: Our aim was to study the relationship of PTH levels with aortic distensibility and CIMT in patients with ICVE. Methods: Sixty-four ICVE patients and 50 control group were enrolled in the study. PTH levels, aortic distensibility and CIMT were measured in all individuals. Results: PTH levels were significantly higher in ICVE patients than in the controls (60.1 +/- 21.6 vs. 52.3 +/- 6.2 pg/ml) (p=0. 008). PTH levels were found to be inversely correlated with aortic distensibility (r= -0. 420, p=0.001) and positively correlated with CIMT ( r:0, 285, p=0,002). Conclusion: The present study shows that PTH levels are increased in patients with acute ischemic cerebrovascular event compared to the control group. It also demonstrates that PTH levels are inversely related to aortic distensibility of ascending aorta and positively associated with CIMT.