Scopus İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/11727/4809
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Item Assessment of Mucosa-Associated Epithelial Chemokine, Thymus-Expressed Chemokine, Periostin and Zonulin Levels in Infants With Atopic Dermatitis(2022) Koksal, Burcu Tahire; Zengin, Hatice Yagmur; Ozbek, Ozlem Yilmaz; 36386107Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease. Skin and gut are the organs that first encounter antigens and environmental triggers. The mechanisms behind the relation between skin and gut immune responses in AD have not been identified yet. Aims and Objectives: To investigate mucosa-associated epithelial chemokine (MEC/CCL28), thymus-expressed chemokine (TECK/CCL25), periostin and zonulin levels in infants with AD. Materials and Methods: Children under one year old participated in the study. We used a propensity matching score. We included 39 infants who had active AD lesions at the time of evaluation. Serum MEC/CCL28, TECK/CCL25, periostin and zonulin levels were measured. Results: We examined age and sex matched 39 infants with AD and 39 healthy infants. Median value of zonulin was lower in infants with AD [49.2 (27.1-71.8) ng/mL] compared to healthy controls [58.5 (27.3-80.8) ng/mL] (P < 0.001). Infants with zonulin levels & LE;55.15 ng/mL had 11.64 times more risk of developing AD than the infants with zonulin levels > 55.15 ng/mL. Infants whose MEC/CCL28 levels were & GE;8.3 ng/mL had 5.83 times more risk of developing AD than the infants with MEC levels < 8.3 ng/mL. Duration of AD and SCORAD index score did not show correlation with MEC/CCL28, TECK/CCL25, periostin and zonulin levels. Conclusion: Low zonulin levels and high MEC/CCL28 levels in infants may show an increased association with AD.Item A Novel Technique for Prediction of Preterm Birth: Fetal Nasal Flow Doppler(2021) Esin, Sertac; Okuyan, Erhan; Gunakan, Emre; Zengin, Hatice Yagmur; Hayran, Mutlu; Tohma, Yusuf Aytac; 0000-0001-8854-8190; 0000-0002-9855-2449; 0000-0001-9418-4733; 33180051; ABI-1707-2020; ABA-3224-2021; AAE-6482-2021Objectives: Absence of fetal breathing movements (FBM) has been found to be a good predictor of preterm delivery in symptomatic patients. However, analysis of FBM patterns and Doppler measurement of them for preterm birth prediction have not been performed before. In this study, we aimed to investigate and analyze FBM patterns in symptomatic preterm labor patients by fetal ultrasonography and nasal Doppler. Methods: This was a multicenter, prospective cohort study. Singleton pregnant patients between 24 and 37 gestational weeks diagnosed with preterm labor were included in the study. Patients were evaluated in three groups: no FBM (Group 1), regular FBM (Group 2), irregular FBM (Group3). Results: Seventy-three patients were available for the final analysis after exclusion. Preterm delivery rate in 24 h in groups were 91.7, 32.7 and 100%, respectively. The absence of FBM (Group 1) was statistically significant for preterm delivery in for both 24 (91.7 vs. 42.6%, p=0.002) and 48 h (91.7 vs. 49.2%, p=0.006) when compared with fetal breathing positive Group 2 and 3. In fetal nasal Doppler analyses in Group 2, the inspiration/expiration number rate was significantly lower in the patients who delivered in 24 h (0 .98 +/- 0.2 vs. 1.25 +/- 0.57, p=0.015). By using fetal nasal Doppler, combination of absence of FBM or irregular FBM or regular FBM with inspiration number/expiration number (I/E) <1.25 detects 94.6% of patients who will eventually deliver in the first 24 h after admission. Conclusions: Examining FBM patterns and using nasal Doppler may help the clinician to differentiate those who will deliver preterm and may be an invaluable tool for managing preterm labor patients.Item A METHOD SUGGESTION TO MEASURE THE EFFECTIVENESS OF INFORMED CONSENT DURING TREATMENT PROCESS A Study on University Students(2019) Buken, Erhan; Yasar, Zehtiye Fusun; Zengin, Hatice Yagmur; Buken, Bora; 0000-0002-4779-0623; 0000-0002-9855-2449; AAL-6847-2021; ABA-3224-2021It is difficult and subjective to evaluate how much of the treatment information given has been understood by the patient during the informing process. Various court decisions show that courts expect a hundred percent success in the informing process. This research was conducted to observe the effectiveness of written and verbal information given under ideal conditions. A coronary angiography consent form was standardized to measure readability and understandability. Two different labyrinth tests were performed from the text. Tests were performed on the Baskent University students in Turkey. The labyrinth test's subjects responded to the test after verbal information, had an absolute rate of 32.5% while the labyrinth test's subjects, responded to prior verbal information had an absolute success rate of 15%. 87.7% of those who achieved absolute success, in the second labyrinth test, also received verbal information. In the verbally informed group, those who achieved absolute success in the first test were 8.5%, while this rate increased to 28.5% after verbal information. There was no difference between the groups, in terms of the number of correct answers and response time, in the first test. Significant differences between the groups' tests arose in the test administered after being informed. This paper argues that the difference of total correct answers between the groups, in the post-test, stems from the effects of verbal informing. This study observed that verbally informing is more effective than written informing. It concludes that the success of the informing process can be measured by developing standardized methods, though it is unlikely to achieve 100% success.