Scopus İndeksli Yayınlar Koleksiyonu

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Author: search.filters.author.Ozdemir, YurdaySubject: search.filters.subject.Brachytherapy

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    Effects of vaginal cylinder position on dose distribution in patients with endometrial carcinoma in treatment of vaginal cuff brachytherapy
    (2017) Ozdemir, Yurday; Dolek, Yemliha; Onal, Cem; 0000-0002-2218-2074; 0000-0002-2742-9021; 28725246; AAG-5629-2021; D-5195-2014
    Purpose: To investigate the impact of different cylinder positions on dosimetry of critical structures in patients with endometrial carcinoma undergoing three-dimensional image-based vaginal cuff brachytherapy (VCB). Material and methods: We delivered VCB at a dose of 4 Gy to a depth of 5 mm in the vaginal cuff of 15 patients using three different cylinder positions (neutral [N], parallel [P], and angled [A]) according to the longitudinal axis of the patient. We analyzed the dose-volume distribution and volumetric variability of the rectum and bladder. We converted the total doses to equivalent doses in 2 Gy (EQD(2)) using a linear-quadratic model (a/b = 3 Gy). Results: The mean rectum volume for the N, P, and A positions was 68.2 +/- 22.7 cc, 79.3 +/- 33.7 cc, and 74.2 +/- 29.6 cc, respectively. The mean rectum volume for the P position was significantly larger than that for the N position (p = 0.03). Relative to the N position, the A position resulted in a lower total EQD(2) in the highest irradiated 2 cc (D-2cc; p = 0.001), 1 cc (D-1cc; p = 0.004), and 0.1 cc (D-0.1cc; p = 0.047) of the rectum. Similarly, the P position resulted in a lower EQD(2) in the D-2cc (p = 0.018) and D-1cc (p = 0.024) of the rectum relative to the N position. In the bladder, the P position resulted in a higher EQD(2) in the D-2cc, relative to the N position (p = 0.02). There was no dosimetric difference between the P and A positions in either the rectum or the bladder. Conclusions: Vaginal cuff brachytherapy in the P and A positions is significantly superior to that in the N position in terms of rectum dosimetry. The bladder dose in the N position is considerably lower than that in the other positions.