Wos Açık Erişimli Yayınlar
Permanent URI for this collectionhttps://hdl.handle.net/11727/10754
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Item A Bibliometric Analysis of Turkey's Contribution to Bone Health Literature from an Endocrinologist Perspective(2019) Degertekin, Ceyla Konca; İyidir, Ozlem Turhan; Yavuz, Dilek Gogas; 0000-0001-5305-6807; K-7904-2019Objective: To analyze the trend of Turkish publications related to bone health with respect to global publications and to determine the relative contribution of endocrinologists to metabolic bone disease literature. Material and Methods: Publications related to bone health up to and including the year 2017 were retrieved from the "Web of Science" (WoS) and "TUrkiye Atif Dizini" (TAD) database using metabolic bone disease related MeSH terms. Excel (v15.30) and Endnote X8 were used to summarize the bibliometric features, including the number of publications, authors, their affiliations, and contributing countries. Keywords were divided, for a detailed analysis, into three clusters: osteoporosis, parathyroid, and vitamin D-related. Results: A total of 1.880.666 papers were retrieved from WoS globally and, of those, 21.165 (1.13%) were published from Turkey. Of the papers published from Turkey, 3.0% were primarily contributed by endocrinologists. The relative contribution of endocrinology to osteoporosis-related (4.6% vs. 1.5%), parathyroid-related (23.7% vs. 5.3%), and vitamin D-related (23.7% vs. 5.3%) publications was higher for articles originating from Turkey compared to the global data. Endocrinology was among the top five specialties contributing to Turkish metabolic bone disease literature indexed in WoS and TAD. Conclusion: Turkey has a less than expected rate of research output in terms of metabolic bone disease. The relatively higher contribution of endocrinology to that effort is promising. Supporting bone research might accelerate the efforts of Turkish researchers in the field of metabolic bone health.Item Emergence of rotavirus G9 in 2012, as the dominant genotype in Turkish children with diarrhea, in a university hospital in Ankara(2019) Kocak, Aylin Altay; Aydin, Merve; Matsumoto, Takashi; Yahiro, Takaaki; Dalgic, Buket; Bozdayi, Gulendam; Ahmed, KamruddinIntroduction: Rotavirus infection is a major cause of morbidity and mortality in infants and young children with diarrhea throughout the world. Material and Methods: In this study, we aimed to determine the detection rate of rotavirus infection in 181 children less than 5 years of age presenting with acute gastroenteritis and admitted to a tertiary care hospital in Ankara, Turkey, from April to November 2012. We documented the epidemiological data by elucidating the prevalent genotypes. Stool specimens were collected, and rotavirus antigen in the samples was detected using ELISA. G and P genotypes were determined by RT-PCR via type specific primers. The nucleotide sequence of the concerned genes was determined by Sanger sequencing and phylogenetic analysis was performed by neighbor-joining method. Results: Of the 181 samples, 28 (15.5%) were positive for the rotavirus antigen. Twenty-seven samples were positive for G genotypes and 21 were positive for P genotypes. Genotypes G1 (7.1%), G2 (7.1%), G3 (7.1%), G4 (3.6%), G9 (71.5%) and P4 (3.6%), P8 (71.4%) were identified. Genotype G9P[8] (50%) was predominant in the combination of G and P genotypes. Most of the G9 strains of this study formed an independent cluster in Lineage III, except two strains which clustered with an Ethiopian G9 strain of 2012. Conclusions: It seems that during 2012 season, genotype G9P[8] increased significantly in Ankara due to a new circulating strain of G9.Item Population-based assessment of gastrointestinal symptoms and diseases: Cappadocia Cohort, Turkey(2019) Sezgin, Orhan; Akpinar, Hale; Ozer, Birol; Toruner, Murat; Bal, Kadir; Bor, Serhat; 31854305Background/Aims: The aim of this study was to determine the prevalence of symptoms and diseases of the lower and upper gastrointestinal system (GIS) in a population-based sample. Materials and Methods: The cross-sectional cohort study was conducted in Cappadocia cohort comprising the Gulsehir and Avanos districts. The "Gastrointestinal Symptom Questionnaire" was applied to persons over the age of 18 years. Results: The GI Symptom Questionnaire was applied to 3369 subjects, and height and body weight were measured in 2797 consenting subjects. Of the participants, 61% were female and the mean patient age was 50 +/- 15 years. At least one GI symptom was present in 70.6% of the cohort. The most common upper GI symptoms were gastric bloating (31.0%) and heartburn (29.1%). The most common lower GI symptom was abnormal defecation (33.5). The prevalence of upper GIS and lower GIS diseases was 32.7% and 12.9%, respectively, and the prevalence of togetherness of upper and lower GIS diseases was 9.9%. Prevalence of GIS disease was approximately 3 times higher in females (p<0.001). All of the upper and lower GI symptoms and the prevalence of upper GIS disease increased in line with Body mass index (BMI). Conclusion: This first population-based, cross-sectional cohort study revealed that the prevalence of GIS diseases is critically high for optimal public health. Special attention must be paid to these diseases while planning health policies and reimbursements.Item Functional Status in Turkish Women with Gynecological Cancer(2014) Akkuzu, Gulcihan; Talas, Melek Serpil; Ortac, FiratBackground: Functional status is the ability to perform daily activities. Little is known about quality of life and health status of gynaecological cancer patients. The present study therefore aimed to evaluate the functional status of women receiving treatment for gynecological oncological disease while not hospitalised. Materials and Methods: This descriptive study covered 42 patients monitored by the Gynecological Oncology Unit in 2011. Data were collected using the Functional Living Index-Cancer and analysed with the chi square test, independent samples t-test, Mann-Whitney U test, one-way ANOVA test and the Kruskal-Wallis H test. Results: Of the 42 cases, 66.7% had been diagnosed within the previous year and 90.5% were undergoing chemotherapy. The most severe symptoms experienced were pain (35.7%), fatigue-weakness (40.5%) and nausea and vomiting (56.5%). Daily activities where the most difficulty was experienced were housework (28.6%), average pace walking (31.0%), carrying more than 5 kg (28.6%). The mean Functional Living Index score was quite high (103.5 +/- 24.1). FLIC-C scale scores did not vary with the educational status, diagnosis duration, and family history of cancer (p>0.05). Conclusions: Evaluation of the functional status of gynecological cancer patients and how they cope with problems should indicate to healthcare professionals what help can be given to maintain quality of life.Item Turkish foreign policy after the 'Arab Spring': from agenda-setter state to agenda-entrepreneur state(2014) Ozpek, Burak Bilgehan; Demirag, YeldaThis article explores Turkey's changing foreign policy approach towards the Middle East after the spread of the Arab upheavals to Syria. Instead of preserving the status quo, Ankara has turned to a revisionist state that has begun to threaten Middle Eastern governments. While Turkey was reluctant to join the foreign military interventions against Middle Eastern regimes, (e. g. Libya) it has been instrumental in immersing NATO in the Syrian civil war. Such transformation ultimately undermines analyses that define Turkey as the kingmaker of the Middle East.Item A View from Young Oncologists on Clinical Trials in Turkey: Obstacles and Solution Proposals(2014) Akman, Tulay; Tanriverdi, Ozgur; Ozturk, Mehmet A.; Petekkaya, Ibrahim; Bakkal, Hakan; Sonmez, Ozlem U.; Avci, Nilufer; Zengin, Seyda; Aksu, Gorkem; Ozyigit, Gokhan; Akbali, HuseyinThere is a new improvement in oncology nearly in every day as a result of preclinical or clinical. As the number of publication per capita, Turkey is far behind the other developed European countries. For example, the number of publications in oncology field is 2.134.964 in the world, it is 15.576 in our country. The most important obstacles for clinical trials in Turkey may be listed as financial problems, difficulties of working conditions, time limitation due to work intensity, inadequate experienced/trained man-power, absence of assistance team at all steps of a scientific trial, difficulties faced during project planning and ethics committee submissions, and lack of motivation. In this article, we, as young oncologists, aimed to discuss the place of Turkey in areas of scientific and clinical trials in the world; underlying causes for inadequate number, type and quality of national studies and possible solution proposals in our country.Item The unmet need for safe abortion in Turkey: a role for medical abortion and training of medical students(2015) Mihciokur, Sare; Akin, Ayse; Dogan, Bahar Guciz; Ozvaris, Sevkat Bahar; 25702066Abortion has been legal and safe in Turkey since 1983, but the unmet need for safe abortion services remains high. Many medical practitioners believe that the introduction of medical abortion would address this. However, since 2012 there has been political opposition to the provision of abortion services. The government has been threatening to restrict the law, and following an administrative change in booking of appointments, some hospital clinics that provided family planning and abortion services had to stop providing abortions. Thus, the availability of safe abortion depends not only on permissive legislation but also political support and the ability of health professionals to provide it. We conducted a study among university medical school students in three provinces on their knowledge of abortion and abortion methods, to try to understand their future practice intentions. Pre-tested, structured, self-administered questionnaires were answered by 209 final-year medical students. The students' level of knowledge of abortion and abortion methods was very low. More than three-quarters had heard of surgical abortion, but only 56% mentioned medical abortion. Although nearly 90% supported making abortion services available in Turkey, their willingness to provide surgical abortion (16%) or medical abortion (15%) was low, due to lack of knowledge. Abortion care, including medical abortion, needs to be included in the medical school curriculum in order to safeguard this women's health service. (C) 2015 Reproductive Health MattersItem Counterfeit Supply Chains(2015) Eser, Zeliha; Kurtulmusoglu, Bahar; Bicaksiz, Adnan; Sumer, Selay IlgazThis paper studies supply chains of counterfeits in Turkey based on insider information from actors in such chains as well as from knowledgeable witnesses. The study depends on semi-structured interviews with actors in or witnesses to such chains. Findings suggest that (i) various forms of counterfeit supply chains exist, (ii) profit margins of counterfeiters seem to be higher than legitimate businesses, (iii) counterfeiters are discouraged if they experience actual or threatened litigation, (iv) law enforcement places higher priority on fighting counterfeits that threaten public health and safety, and (v) counterfeits appear to drive down the prices of legitimate products. Overall, poor action by legitimate businesses against counterfeiters, weak institutional efforts on the part of law enforcement and low consumer awareness appear to foster counterfeit supply chains, or at least contribute to their persistence. (C) 2015 The Authors. Published by Elsevier B.V.Item Problematic Areas Related to Sexual Life of Individuals with Gynecological Cancer: A qualitative Study in Turkey(2015) Pinar, Gul; Pinar, Tevfik; Akalin, Ayse; Saydam, Tulay; Ayhan, AliThis study was conducted to examine problematic areas related to sexual life of individuals with gynecological cancer. Qualitative phenomenological research design was used in the study. The data were collected through "Semistructured In-depth Interview Form" and "Individual Information Form" with 30 women diagnosed with gynecological cancer. In-depth interview technique was used for obtaining data related to sexual problem areas of women. The data obtained were evaluated by content analysis. Average age of women who participated in the study was 46.70 +/- 10.66 (min=30, max=67), and women who were followed for the diagnosis of endometrium cancer (53.3%), ovarian cancer (36.7%), cervical cancer (10%). It was determined that there were significant changes in sexual lives of the individuals following the illness, and that body image, role of sexuality, sexual functions and reproduction ability, which are the four important components of sexual health, were affected unfavorably to a great extent. It was determined in this study that individuals with gynecological cancer face multidimensional problems regarding sexual life. Adoption of holistic approach by health professionals in the evaluation of sexual problems of women and attempting to solve the problem are of significance.Item Design and rationale of dabigatran's stroke prevention in real life in Turkey (D-SPIRIT)(2016) Turk, Ugur Onsel; Alioglu, Emin; Tuncer, Esref; Ozpelit, Mehmet Emre; Pekel, Nihat; Tengiz, Istemihan; Cetin, Nurullah; Dalgic, Onur; Topaloglu, Caner; Bilgin, Nazile; Altin, Cihan; Ozdemirkiran, Tolga; Tuluce, Kamil; Turkoglu, Ebru Ipek; Ozpelit, Ebru; 27138311Objective: The D-SPIRIT registry is designed to investigate the safety and efficacy of dabigatran etexilate in patients with nonvalvular atrial fibrillation (NVAF) and to collect data on outcomes in clinical practice. Methods: The D-SPIRIT is a national, prospective, observational, post-marketing registry involving patients with NVAF who have been taking dabigatran etexilate therapy for stroke prevention for a minimum of 6 months prior to enrollment. The registry will collect and analyze data from routine care, enrolling up to 600 patients in 9 centers. Patients will be followed up for 2 years to evaluate effectiveness and safety. A sample size of 600 subjects is proposed based on the following assumptions; Two-sided significance level of 0.05 (1-sided significance level of 0.025), ischemic stroke incidence rate of 0.768%-1.111%, hemorrhagic stroke incidence rate of 0.109%-0.130%, transient ischemic attack incidence rate of 0.722%-0.623%, therapy discontinuation incidence rate of 40% at day 730, and duration of enrollment period of 12 months with non-uniformed enrollment rate. Ethics approval was given by Dokuz Eyll University Ethics Committee of Clinical Research (2014/54) and approved by the Turkish Ministry of Health. Conclusion: Potential results of D-SPIRIT registry will add data from clinical practice to those from the RE-LY trial to expand knowledge of dabigatran etexilate treatment in patients with NVAF.