Wos Açık Erişimli Yayınlar
Permanent URI for this collectionhttps://hdl.handle.net/11727/10754
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Item Pili Multigemini Is a Possible Risk Factor for Pilonidal Sinus Disease(2021) Ekici, Yahya; Moray, GokhanThe aim of this study is to analyze both previously proposed and new risk factors for the development of pilonidal sinus. This is a prospective case-control study consisting of 145 patients with pilonidal sinus disease (n = 45) and a control group (n = 100). All patients were admitted to the department of general surgery between January 2013 and May 2015. The patients' age, family history, medical history, sitting time in a day, sitting posture, body mass index (BMI), Garn hairiness score, and hair type were evaluated. There were significant differences between the groups in the following characteristics: age (P = 0.01); positive family history (P = 0.01); medical history (P = 0.01); sitting time in a day (P = 0.01); sitting posture (P = 0.01); BMI (P = 0.01); Garn score (P = 0.01); and hair type. Multivariate logistic regression analysis indicated that positive family history (P = 0.03); Garn score (P = 0.05); medical history (P = 0.01); and sitting posture (P = 0.02) were independent risk factors for the development of pilonidal sinus disease.Item The effect of static magnetic field on partial thickness burn wound healing(2019) Soy, Ebru H. Ayvazoglu; Aydin, Huseyin Onur; Terzi, Aysen; Ekici, Yahya; Moray, GokhanAim: During the past decades, there has been a substantial and growing evidence that static magnetic fields (SMF) and pulsed electromagnetic fields (EMF) can both produce satisfying therapeutic effects on various disorders. There have been researches about the efficacy of SMF in wound healing. However, there is no any investigation about the efficacy of SMF in burn wound healing. In this experimental study, we aimed to investigate the efficacy of SMF in partial thickness burn wound in rats. Material and Method: Forty male Sprague-Dawley male rats were used in the experiment. The modification of Sawada's bum model was applied. In Group1 magnets, in Group2 non-magnetic bars were placed vertically to the burn wound. In Group3 magnets, in Group4 non-magnetic bars were placed horizontally to the burn wound. The wound heating is evaluated by gross wound healing rate and histopathological examination. Results: In study groups, wound healing was faster, granulation with fibroblast migration was earlier, collagen production and neovascularisation were more than control groups. We found no relationship between wound healing and vector direction. Discussion: According to these results static magnetic field can be used in clinic to promote the healing in patients with burns. Especially, in cases that have no chance for grafting, to decrease complications and increase the survival, the static magnetic field can be an alternative.Item Effect of the Bioadhesive, BioGlue, on Impaired Colonic Anastomose Healing in Rats(2015) Ekici, Yahya; Akcay, Eda Yilmaz; Moray, GokhanColonic anastomotic leakage is still a problem in general surgery practice. We sought to investigate the effect of a new tissue adhesive, BioGlue, on the healing of normal and impaired colonic anastomoses. Sixty-four rats were randomized into 4 groups. In all animals, a 1-cm segment of the left colon was resected, and an end-to-end sutured anastomosis was created. Animals were then divided into 2 groups: normal and impaired anastomosis. These 2 groups were further subdivided into 2 additional groups: animals that received BioGlue and those that did not. All rats received intraperitoneal injections of either 0.9% NaCl or 5-fluorouracil (5-FU). Anastomotic evaluation was done 7 days after surgery. Macroscopic healing, mechanical strength, and histopathologic healing parameters were evaluated. Leakage of the anastomosis was significantly higher in rats in the impaired group compared with those in the BioGlue groups (P = 0.043). The adhesion formation score was significantly higher in rats in the impaired anastomosis group compared with the other groups. Bursting pressures were significantly lower in the impaired anastomosis group than in the other ones (P = 0.001). Neoangiogenesis and fibroblast activity were different among the groups (P = 0.001). Inflammatory cell infiltration and collagen deposition did not differ among the groups (P = 0.07). Immediate postoperative intraperitoneal administration of 5-FU after colonic anastomosis inhibits intestinal wound healing. Covering colon anastomoses with BioGlue after suturing conferred beneficial effect on healing.Item Effect of Topical Platelet-Rich Plasma on Burn Healing After Partial-Thickness Burn Injury(2016) Ozcelik, Umit; Ekici, Yahya; Bircan, Huseyin Yuce; Aydogan, Cem; Turkoglu, Suna; Ozen, Ozlem; Moray, Gokhan; Haberal, Mehmet; 27262706Background: To investigate the effects of platelet-rich plasma on tissue maturation and burn healing in an experimental partial-thickness burn injury model. Material/Methods: Thirty Wistar albino rats were divided into 3 groups of 10 rats each. Group 1 (platelet-rich plasma group) was exposed to burn injury and topical platelet-rich plasma was applied. Group 2 (control group) was exposed to burn injury only. Group 3 (blood donor group) was used as blood donors for platelet-rich plasma. The rats were killed on the seventh day after burn injury. Tissue hydroxyproline levels were measured and histopathologic changes were examined. Results: Hydroxyproline levels were significantly higher in the platelet-rich plasma group than in the control group (P=.03). Histopathologically, there was significantly less inflammatory cell infiltration (P=.005) and there were no statistically significant differences between groups in fibroblast development, collagen production, vessel proliferations, or epithelization. Conclusions: Platelet-rich plasma seems to partially improve burn healing in this experimental burn injury model. As an initial conclusion, it appears that platelet-rich plasma can be used in humans, although further studies should be performed with this type of treatment.Item Arterial complication of irreversible electroporation procedure for locally advanced pancreatic cancer(2016) Ekici, Yahya; Tezcaner, Tugan; Aydin, Huseyin Onur; Boyvat, Fatih; Moray, Gokhan; 0000-0003-3795-5794; 0000-0003-2498-7287; 0000-0002-3641-8674; 27795815; S-8185-2018; AAE-1041-2021; M-1422-2019; AAD-9865-2021; F-4230-2011Irreversible electroporation (IRE) is a non-thermal ablation technique used especially in locally advanced pancreatic carcinomas that are considered surgically unresectable. We present the first case of acute superior mesenteric artery (SMA) occlusion secondary to pancreatic IRE procedure that has not been reported before in the literature. A 66-year-old man underwent neoadjuvant chemoradiotherapy for locally advanced pancreatic ductal adenocarcinoma. IRE procedure was applied to the patient during laparotomy under general anesthesia. After finishing the procedure, an acute intestinal ischemia was detected. A conventional vascular angiography was performed and a metallic stent was successfully placed to the SMA and blood flow was maintained. It is important to be careful in such cases of tumor involvement of SMA when evaluating for IRE procedure of pancreatic tumor.Item Laparoscopic spleen-preserving distal pancreatectomy for a primary hydatid cyst mimicking a mucinous cystic neoplasia(2017) Tezcaner, Tugan; Ekici, Yahya; Aydin, Onur Huseyin; Barit, Gonca; Moray, Gokhan; 0000-0003-2498-7287; 0000-0002-3641-8674; 0000-0003-3795-5794; 28281482; AAE-1041-2021; AAD-9865-2021; M-1422-2019; S-8185-2018Pancreatic hydatid cysts are fairly rare. The disease can be encountered concurrently with systemic involvement or as an isolated pancreatic involvement. We report the first case of spleen-preserving laparoscopic distal pancreatectomy for a pancreatic hydatid cyst. There was no complication or recurrence. A 55-year-old woman was admitted to our centre with epigastric and back pain. Upper abdominal magnetic resonance imaging revealed a solitary cystic lesion with septations at the pancreatic tail level measuring 24 mm x 18 mm, which was initially thought to be a pancreatic mucinous cystic neoplasia. She underwent laparoscopic spleen-preserving distal pancreatectomy and cholecystectomy. Her post-operative course was uneventful and histopathological examination revealed a hydatid cyst in the pancreatic tail.Item Long-term and Perioperative Outcomes of Laparoscopic and Open Surgery for Rectal Cancer(2018) Aydin, Huseyin Onur; Ekici, Yahya; Karakayali, Feza Yarbug; Tezcaner, Tugan; Ozgun, Gonca; Yildirim, Sedat; Moray, GokhanObjectives: The necessity of comparing oncologic results with the use of minimally invasive surgery in rectal cancer has arisen. The aim of the present study was to evaluate the treatment approach in rectal cancer and to compare the outcomes of laparoscopic and open surgery. Methods: Patients who underwent surgery for rectal carcinoma between January 2006 and January 2016 in our institution were evaluated. The results were compared between the two groups according to open or laparoscopic surgery. Clinical characteristics, preoperative and postoperative results, pathological examination results, and disease-free survival rates were compared after the surgical procedure. Results: A total of 121 patients were included in the study. Of the patients, 50 underwent open, and 71 underwent laparoscopic surgery. The median follow-up times were 56.75 months in the open surgery group and 55.2 months in the laparoscopic surgery group. Pathological examination revealed similar numbers of lymph nodes in both groups (p>0.05). The duration of hospital stay was statistically significantly lower in the open surgery group than in the laparoscopic group (p<0.05). The rates of disease-free survival were 74% in the open surgery group and 82.5% in the laparoscopic group, and no statistically significant difference was found (p>0.05). Conclusion: There was no significant difference in complication and recurrence between laparoscopic and open surgery for rectal cancer in our study. The duration of hospital stay of patients was statistically significantly lower in the laparoscopic group than in the open surgery group. Laparoscopic or open surgical options could be preferred according to the clinical suitability of the patient, experience of the surgeon, and resources of the center in rectal cancer treatment.